this is so well done! both hilarious and sad simultaneously

Dr. Jean Fan@jef.works · 3mo ago

As academic audit culture grows (now NIH pre-approvals for conferences and foreign collaborators), I hope students will remember there is another way: an academia built around mutual trust and obligation through collective effort. My take on the neoliberal academic ecosystem: youtu.be/PGO4qgfm7DU

1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

DNA-guided transcription factor interactions extend human gene regulatory code - Nature

A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

nature.com

Happy to present the first preprint from my lab after relocating @CHOP_Research @ChildrensPhila Here we describe gene expression at the single cell level across major milestones of human and mouse development. preprint here: https://buff.ly/3PFWNoG

Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene www.sciencedirect.com/science/arti...