Kalli Kappel

@kallikappel.bsky.social

Assistant Professor at UCLA HHMI Hanna Gray Faculty Fellow PhD: Stanford Biophysics; Postdoc: Broad Institute Excited about RNA+proteins+IDPs, high-throughput experiments+computation

Roadtrip. For some, it might be vacation, for others it's a roadtrip from their postdoc to their new lab. I interviewed two scientists who kindly shared personal insight into what that feels like. And yes, they know that many are not having the good fortunate of landing a faculty job just yet. A 🧵

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

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