Katharina Schmack

@kathaschmack.bsky.social

Psychiatrist | Neuroscientist | Founding Member of the Psychosis Collective @TheCrick @UCLPsychiatry

🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵

Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

Glad to read in the Guardian today that some German concepts central to indoor wellbeing are becoming more widely appreciated 😅 Read on for a short glossary on indoor climate for those living with people raised in Germany

I was so busy conferencing that I only took one photo on arrival! Wonderful to see old friends, make new ones, and talk bottomless science. My goal for ACNP 2027: make it onto the @ahmarilab.bsky.social #fashionsOfAcnp feed 😀 #acnp2026 @acnporg.bsky.social

Wide view of a coastal resort at dusk, with palm trees, illuminated pools and walkways in the foreground, and the ocean stretching across the horizon under a fading blue sky.
ACNP@acnporg.bsky.social · 7mo ago

📸 One last favor: Share your favorite photo from the meeting and tag us! We’d love to see #ACNP2026 through your eyes. Until next year... stay inspired!

For anyone who made it through the “Everything was better back then” moments of the holiday season: Reward sensitivity declines with age. That might explain why apples tasted like apples, music felt real, and TV was just better.

LinkedIn got my thoughtful 2025 year-in-review reflection. Bluesky gets the stupidest thing I did in 2022: Booking travel to a conference in Maine, happily thinking “Cool, there’s a direct flight from London to Portland.”

New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.

A frontal motor circuit for economic decisions and actions

Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...

biorxiv.org

One great thing about having kids: you do all the fun things you would never do otherwise – and your body immediately reminds you why 😅 Still, the 45-second slide ride down this #London sculpture tower, the ArcelorMittal Orbit, was absolutely worth the stiff neck!

A view of the ArcelorMittal Orbit in London, a tall red looping steel sculpture with a long enclosed slide spiralling around it. The photo is taken from street level with a tree in the foreground and a cloudy sky in the background.

Introducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯 When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep) #sfn2025 #sfn25

He: You spent money on an AIR PURIFIER? Me: [erupting into a 15-minute talk on air pollution in cancer and dementia, confidently citing studies I once skimmed] He: You really should be in sales. Me: That's half my job, using vague recollections of science to convince people to fund more science.

Apply to become a CSHL-Simons Fellow in Neuroscience! Run your own lab, pursue bold ideas, join a highly collaborative community! All areas including experimental or computational neuro, including NeuroAI & systems PhD required; ≤~1 yr postdoc www.cshl.edu/about-us/car...

Fellows Positions | Cold Spring Harbor Laboratory

CSHL Simons Fellow in NEUROSCIENCE Cold Spring Harbor Laboratory (CSHL) is seeking to fill a Cold Spring Harbor Laboratory Fellow position in the area of NEUROSCIENCE (experimental and/or computationa...

cshl.edu

Scenes from our lab Slack channel: “Ugh… that’s disappointing.” “Wait, let me check.” “Hold on, something’s funny…” “WHAT?!” “Ohhh… that’s actually interesting.” “Back to the analysis we go…” “No way… THE EXPERIMENT WORKED!” I love this team! The rollercoaster of science never gets old! 😍🔬

two elderly women are riding a roller coaster together and one is covering her face .

Alt: two elderly women are riding a roller coaster together and one is covering her face .

media.tenor.com