Finished My Hero Academia.... Damn man hopecore to the max. Go Beyond Plus Ultra baby!!!
Dr. KC Ortiz, Process Chem Enjoyer
@kcortiz.bsky.social
Gardening, Gundams, and Games. Big Critical Role Fan & Kinda Funny Fan, Process Chemist. PhD Chem Auburn '24 | BS Chem TAMU '16 | Dog/Cat Dad | He/Him | Big Wife Guy
pubs.acs.org/doi/10.1021/... New Dadphos out today in JACS. V cool @bagphos.bsky.social
Annulative Skeletal Diversification of Pyrimidines to Expanded Heteroaromatic Space
Single-atom skeletal editing has recently emerged as a powerful strategy for the direct diversification of the heterocyclic cores of various compounds. Yet, methods that enable monocycle-to-bicycle transformations that involve core atom changes remain scarce. Herein, we report a two-step, one-pot protocol that converts pyrimidines into 7-azaindazoles and pyrazolo[1,5-a]pyrimidines, two privileged scaffolds in medicinal chemistry. Fine-tuning the reaction parameters enables chemodivergent control, allowing selective access to either framework, with the pyrimidine scope including pharmaceutical drug molecules. Moreover, the strategy has been extended to afford differently substituted pyrimidines, partially saturated fused skeletons, and quinoline derivatives. Access to this broad, expanded, heteroaromatic space underscores the potential for heterocyclic diversification using this approach.
pubs.acs.org
www.nature.com/articles/s41... COOL LIT ALERT (thanks @ndchiappini.bsky.social for the heads up)
Rewiring amino acids to piperidines - Nature Catalysis
Bioactive piperidines are among the most common motifs in pharmaceuticals, yet accessing their chiral, highly substituted forms remains challenging. Now, a copper-catalysed reaction of amino-acid-deri...
nature.com
Offer signed. New Title: Process Chemistry Scale-Up Scientist, Vertex Pharmaceuticals 🫡
MFW finding a pyridine nomenclature mistake in this paper
We're moving and I'm gonna be taking a nice train to work from now on.... Its gonna be just like Persona 5 omg
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Critical Role Campaign 2 will always be my favorite b/c you get to watch Travis Willingham and Laura Bailey fall in love all over again 😭😭😭😭😭😭😭😭😭😭
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Swan Songs by Hollywood Undead might be a perfect album. "Who are we angry at?" "The haters" "Who exactly are 'the haters'" "Idk the people who hate!!"
FOUND A WAY TO PURGE IMPURITY BELOW SET SPECS. SLIME ME UP CUH LFG!!!
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Me: hey isolated side product can I spike you into my reaction and see if you're the cause of this impurity I'm seeing?? Isolated Side Product: best I can do is turn your reaction orange with zero impact on impurity formation...
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www.nature.com/articles/s44... Ok but @bagphos.bsky.social still doesn't have a JACS 🙄 (this is a joke post and should not be taken seriously, I'm super excited for Dadphos and his work!!!)
Oxygen migration into carbon–carbon single bonds by photochemical oxidation - Nature Synthesis
Heteroatom insertions into chemically inert carbon–carbon single bonds are rare compared to their unsaturated analogues. Now, ligand-to-metal charge transfer offers a promising entry point for oxygen ...
nature.com
Last full week of work at my dream job....it's bittersweet man. Hard knowing that I've succeeded and delivered on every project I've worked on and yet ultimately factors out of my control are sending me to new pastures. C'est la vie
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An autumn evening on the Mill River, East Rock Park, New Haven, Connecticut, USA. 🧪🌿🌎🐡 #wildlife #scicomm #sciviz #wildlifephoto #NaturePhotography #visualscicomm #sciviz #scicom#streams #rivers #NewHaven
Linkedin my dude "Cracking" doesn't mean what you think it means now a days....
We tied 1 to 1 with the team that's won the league for the last 3 6 week seasons... Lost by 1 on PKs with a shot that barely got by me 😮💨 Pretty fun game though all in all!
Dr. KC Ortiz, Process Chem Enjoyer@kcortiz.bsky.social · 10mo agoI've been playing soccer in the same league for the last year with the same team... Tonight is the last playoffs I'll play with them b/c of the upcoming move. Bittersweet yo
I've been playing soccer in the same league for the last year with the same team... Tonight is the last playoffs I'll play with them b/c of the upcoming move. Bittersweet yo
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Starting my music tattoo project on my left leg! Will be filling in the hexagons with my favorite songs from various pieces of media designed by various tattoo artist! Super excited. Shout out to Clair Obscur Expedition 33!
Hiring manager: there were a lot of applicants from top tier schools Me: ok I can't change my school, so what can I actively work on to improve? Hiring manager: 🤷♂️ What an incredible interaction to be frank. Especially as I've continuously succeeded in my current role inside & out of the lab.
Sorry y'all. I went 9/10 as goalie last night so I probably blocked the rapture too. My b.
Still can't believe I got multiple interviews deep in the process for a position only to then be told "you're a fantastic candidate but we can't move on due to concerns over rapidly changing immigration policies".
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MFW James Gunn's Superman refreshes me and my endless pursuit of hopefulness and positivity 🥹
Random KC Lore: At 17 I was the Class Leader/Officer for warlocks in one of the top guilds in the US in World of Warcraft. I scheduled/ran interviews with recruits for our 4x weekly 4 hr raids involving member meetings and raid performance tests. They were legit job interviews.
Meet The Speaker: Prof. Abby Doyle @uclachem will be our first speaker at the next @organicdivision.org Virtual Symposium on July 16 at 12 noon (ET) #ChemSky Watch for free at: YouTube: orgn.link/watch Zoom: orgn.link/vs-zoom More info: organicdivision.org/doc-virtual-sy…
Microsoft: Cuts thousands of jobs to free up budget for undesired AI Meanwhile the twisted monstrous chimera of OneDrive, SharePoint, and Teams:
Good morning you cool chemistry peeps in all fields at all levels! I'm giving a talk to undergrad chem research students at my alma mater next week! What advice would you give to your younger self? What do you wish you would have known post-undergrad (grad school/career)
