The experimental strategy overcomes hurdles that have long stymied researchers studying neuropsychiatric illness in lab-grown brain tissue go.nature.com/4ixYQe1

Human brain cells transplanted into mice in ‘most extensive’ integration ever

Lab-grown organoids wire into mice missing a key part of their brain, offering a new way to test drugs for developmental conditions.

go.nature.com

Replacing the mouse cortex with human-derived brain organoids could offer a new way to study how circuits form and conditions such as autism. By @briannaabbott.bsky.social www.thetransmitter.org/spectrum/hum...

Human brain organoids flourish in emptied mouse cortex

The chimeric mice could help untangle the biology of human brain development or conditions such as autism.

thetransmitter.org

Scientists replaced half a mouse’s brain with a few million human neurons. It could become new way to study dementia and other brain disorders. Gift link: nyti.ms/4xqUcCk

Scientists Fuse Human Neurons Into the Brains of Mice (Gift Article)

The studies may help reveal the causes of brain disease in people and point the way to treatments. But researchers already are calling for new ethical guidelines.

nyti.ms

1/ I have long dreamed of systems that could causally model human neurobiology across scales, from molecular to behavioral. In @nature.com, delighted to share our efforts at creating xenocortical mice where human organoids grow to occupy most of mouse cortex.

Thrilled to join the NGL program! Grateful for the opportunity to engage with NGL peers and the @alleninstitute.bsky.social scientists behind the incredible datasets that support so much of my work.

allen institute@alleninstitute.org · 2y ago

Congrats to: @ismail-ahmed.bsky.social @azaallsop.bsky.social al Jessica Butts @r3fang.bsky.social y.social @kevinkelley.bsky.social sky.social Mariajose Metcalfe @droligo.bsky.social y.social Fan Zhang Read the full announcement: alleninstitute.org/news/allen-i...

Great to see our paper online! Amazing collaboration with Neal over the years, with lots of help from others in the Pasca group.

Sergiu P. Pasca@sergiuppasca.bsky.social · 2y ago

Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS