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Katie Houlahan

@khoulahan.bsky.social

Assistant Professor @ McMaster University. Studying the impact of inherited DNA variants on tumour evolution.

25 Posts36 Follower85 Folgt
Noah F. Greenwald@noahgreenwald.bsky.social · 2y ago

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) 🧪🧬 🖥️ #AcademicSky #MLSky #ImmunoSky www.biorxiv.org/content/10.1...

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition

Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast cancer (TNBC) benefit from ICI, and the deter...

biorxiv.org

Katie Houlahan@khoulahan.bsky.social · 2y ago

The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...

Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature

A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...

nature.com