Kate Michie

@kmichie.bsky.social

Interested in Structural Biology, deep learning, NextFlow, HPC, viruses, missense mutations archaea, bacteria, evolution & random quirks of nature. (Protein Cosmos feed 🧶🧬) Leads a research group & Structural biology Facility,UNSW Sydney. Opinions my own.

Excited to hear @rolanddunbrack.bsky.social talk today ( 1 pm Sydney time) on “Structural bioinformatics and AlphaFold modeling of the human kinome and its interactions” at the Australian Structural Biology Computing community meeting. Details to join the talk:

MEETING: Australian Structural Biology Computing Community — Australian BioCommons

Join the quarterly meeting of the Australian Structural Biology Computing community. More information

biocommons.org.au

This should give our archaeal structural protein predictions a long-needed boost. This ‘dark space’ has been a frustrating limit and I’m excited to see the impact. Great work Pedro! 🥳🧶🧬

Pedro Leão@pedroleao.bsky.social · 2mo ago

I'm happy to share the first pre-print of out Lab! 🎉 Introducing ArchaeaHQ www.biorxiv.org/content/10.6... We curated 21,644 genomes across all 4 archaeal kingdoms to bridge the gap in public datasets for computational biology What is inside ArchaeaHQ... (1/2)

Archaea and bacteria reveal the ancient origins of another ‘eukaryotic’ complex. Membrane trafficking is old… check this out for an integrative approach showing how bioinformatics and computational structural methods marry with x-ray crystallography and cryo EM to reveal biology in all its beauty.🧶🧬

The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking - Nature Communications

COMMD proteins assemble into a heterodecameric ring in the Commander complex, which plays a role in endosomal membrane trafficking and signalling in eukaryotes. Here, Liu et al. identify COMMD-like pr...

nature.com

🧶🧬Tomorrow ASBC community talks:Dr Cameron Gilchrist is talking about “Multiple protein structure alignment with FoldMason” Wed 20th May Sydney, Brisbane, Canberra, Melbourne, Hobart (AEST) : 1 pm - 2 pm Adelaide (ACST): 12.30 pm - 1.30 pm Perth (AWST): 11 am - 12 pm For details of joining:

MEETING: Australian Structural Biology Computing Community — Australian BioCommons

Join the quarterly meeting of the Australian Structural Biology Computing community. More information

biocommons.org.au

It’s my favourite famous human’s birthday today! Happy 100th Birthday Sir David Attenborough. How many of us went into careers in science inspired by him? When the world seem bleak he always reminds me to look at the wonder of the natural world to see something worth fighting for

From fossicking for fossils to a champion for life on Earth: Sir David Attenborough at 100

David Attenborough has captured and told the stories of nature to millions of people – and inspired scientists and conservationists the world over.

theconversation.com

Science is at a critical juncture. More and more fundamental researchers are turning to private company jobs because they ‘pay’. More and more tech is being locked away 😳Why? Because western society has stopped valuing scientists. It’s all a bit scary. What world do we want for our kids? 🧶🧬

What’s up everyone with the division? So much noise creating wars between generations, genders, political parties, religion, cultures and nations. Humanity left the trees based on the back of being able to work together. Why is everyone so hell bent on going backwards right now?🤔 Happy Friday.

Amazing talk today by Prof Elitza Tochaeva about the evolution of bacterial cell membrane and walls. Certainly got me thinking about bacterial and archaeal membranes. It is such a joy to see so many problems that are progressively being solved by Cryo ET. 🥰 🧬🧶 @unswbabs.bsky.social

Elitza Tochaeva presenting her work at UNSW today

So nice to see this story! Jan is like a dog with a bone chasing this down. The origin of alpha/beta tubulins has been a question he won’t let go of. Great collaborative team effort and careful work. Recommended 🧬🧶

Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺@ettema.bsky.social · 6mo ago

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...