Another great PhD thesis defense this week @CReM_Boston, this one from newly minted Dr. Julian Amirault of the @GMostoslavsky Lab, focused on the generation of human iPSC-derived CD4+ T cells! Congrats, Dr. Amirault!

Our latest work from The KottonLab, just out now, focused on lung endothelium: "A chimeric human-mouse lung vascular model using induced pluripotent stem cells reveals insights into the pathogenesis of BMPR2-related pulmonary hypertension": www.biorxiv.org/content/10.6...

Congratulations to Dr. Chris Reardon, this years Chadwick Medal awardee at the⁩ 2026 Massachusetts Thoracic Society annual meeting! Our program director at the BU/BMC Pulmonary Fellowship Training Program. Congrats, Chris!

Congrats to Dr. Andrew Wilson's Lab and MD/PhD student/first author, Carly Merritt on their new paper: "AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema" www.biorxiv.org/content/10.6...

The Kotton Lab announces our latest biorxiv posting; a collaboration with the labs of Jessie Huang @hjhjess and Will Zacharias. "The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells" www.biorxiv.org/content/10.6...

Congrats to first author, Dr. Andrea Alber, co-senior-author Dr. Kostas Alysandratos, and all the team @crem-boston.bsky.social . For patients with pulmonary fibrosis this new human model system should help propel drug discovery and therapeutic development. #helpisontheway! #itsthecells!

Darrell Kotton@kottond.bsky.social · 6mo ago

The Kotton Lab is pleased to announce our latest work, just posted at biorxiv: Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis www.biorxiv.org/content/10.6...

The Kotton Lab is pleased to announce our latest work, just posted at biorxiv: Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis www.biorxiv.org/content/10.6...

Just out @ajrcmb.bsky.social, our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients: atsjournals.org/doi/abs/10.1...

Yesterday, October 7, Sir John Gurdon passed away. Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka. Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.

Delighted to give a talk at the Vermont Lung Stem Cell Conference last week. Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University @crem-boston.bsky.social #CureIPF

Thrilled to host Dr. Hao Zhu @crem-boston.bsky.social as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the @Zhu_Lab in Anita's honor. #itsthecells

Excited to help spread the word about the latest advances in stem cell research! #itsthecells!

Boston University Chobanian & Avedisian School of Medicine @bumedicine.bsky.social · 10mo ago

Congratulations to BU's Darrel Kotton, MD, who has joined 12 other distinguished researchers on the editorial board for Stem Cell Reports, the official journal of the International Society for Stem Cell Research.

Great research by our own, Dr. Elizabeth Taglauer @The_BMC @CReM_Boston, featured today: "One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies" healthcity.bmc.org/one-nicu-doc... #itsthecells #helpisontheway!

One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies

Dr. Elizabeth Taglauer uses lung cells to study placental biology and how the placenta can disrupt babies’ development in preeclampsia.

healthcity.bmc.org

Announcing our latest publication, just out today @NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications

The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

nature.com

“David Baltimore, a biologist who in 1975 won a Nobel Prize for a startling discovery that seemed to rock the foundations of the fledgling field of molecular biology, died on Saturday at his home in Woods Hole, Mass. He was 87.”🧪🩺

An incredible advance in regenerative medicine, published this week: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM: www.nejm.org/doi/full/10....

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

nejm.org

Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

nejm.org

So great to be together with so many @CReM_Boston alumni and current members at the #2025LungGRC!

The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch

Farewell #2025LungGRC! Great memories as we say farewell, handing off the ball to our new Chairs. #2025LungGRC. @GordonConf

The traditional epithelium vs mesenchyme soccer game, won this year by a new team, Bronchospurs at the 2025 Lung Gordon Research Conference! #2025LungGRC. @GordonConf

Today we officially hand over our meeting Chair roles to the next Chairs: Drs. Cardoso and Crotty Alexander on Day 5 of the 2025 Lung Gordon Research Conference. Special thanks to Dr. Sue Majka, current Chair!

And we are live at the #grclung2025 in Tuscany!

KaminskiMed@kaminskimed.bsky.social · last yr.

At 9:45PM, the lecture hall in Tuscany is still full, discussion going strong, although half of the attendees just flew across the Atlantic. That’s the spirit of science I love Gordon Conference of Lung Development, Injury and Repair. #GRCLung2025 #ScienceMatters #LungResearchersAreBest

Our latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...

Congrats @MingxiaGu and all the teams collaborating on this latest advance in stem cell and lung organoid research, just out @CellCellPress! and thanks for including our iPSCs! www.cell.com/cell/fulltex...

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Recapitulating the concurrent development of germ layers through the co-differentiation of mesoderm and endoderm within a single spheroid enabled the generation of vascularized lung and intestinal org...

cell.com

Truly amazing pluripotent stem cell clinical trial results for diabetes! “Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results”. Also published in ⁦‪@NEJM‬⁩ this week. #helpisontheway! www.statnews.com/2025/06/20/s...

Off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results

An off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results, according to a new study.

statnews.com

RFK Jr. plans to bar NIH scientists from top journals like NEJM & JAMA, replacing them with government-run outlets. This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School. www.washingtonpost.com/health/2025/...

RFK Jr. says he may bar scientists from publishing in top medical journals

Health Secretary Robert F. Kennedy Jr. took aim at reputed journals such as the Lancet and said his agency will create “in-house” publications instead.

washingtonpost.com

“This is incredibly disappointing,” said Dr. Camille Kotton, an infectious diseases physician who cares for immunocompromised patients, and a former adviser to the CDC ”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”

F.D.A. Approves Novavax Covid Vaccine With Stricter New Conditions

nytimes.com

An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy” #helpisontheway! www.pennmedicine.org/news/news-re...

World's First Patient Treated with Personalized CRISPR Therapy

In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children’s Hospital of Phila...

pennmedicine.org

The ATS is pleased to recognize Lauren Kearney, MD, as the 2025 Ziskind Clinical Research Scholar Award winner. Dr. Kearney aims to advance early detection of lung cancer, increase access to preventive care and treatment, and reduce health disparities. Read more: www.thoracic.org/professional...