The interfacial geometry of the epithelium has direct mechanical effects on cancer cells. In regions of higher tension, cancer cells acquire stem cell properties. This was demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social buff.ly/GYlyEBH

In this review, @gsilvani.bsky.social, Martina Stenzel, & @kriskilian.bsky.social of @nanomed-unsw.bsky.social discuss how advances in #organoids & perfusable MPS are transforming nanoparticle design & accelerating nanodrug development by enabling more predictive assessments of efficacy.

Interested in mechanical forces influencing phenotype plasticity? Check out our latest work, led by Giulia Silvani, where we used microfluidic models to explore #melanoma cells transiting tight spaces—constriction induced invasiveness and tumorigenicity… www.nature.com/articles/s41...

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1 - Nature Communications

Cancer cells can squeeze through confined spaces and undergo nuclear deformation, leading to changes in chromatin organisation. Here, the authors show that mechanical constriction in microcapillaries ...

nature.com

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Head of the Cell Biology and Biophysics Unit

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

embl.wd103.myworkdayjobs.com

Work needs to be tempered with play. Some of my best ideas have come from introspective mountain time. I thought I needed a new ski jacket, but alas @nanomed-unsw.bsky.social had me covered 🤩 #acn #nanomedicine #treblecone #wanaka 🇳🇿🏂❄️

Hot off the press! Exploring phenotype plasticity in confined spheroids @nanomed-unsw.bsky.social Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface - Soliman - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface

Drop-on-demand printing is used to replicate the spatial compartmentalization of the breast cancer-host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface t...

advanced.onlinelibrary.wiley.com

Interested in a #postdoc on nuclear #mechanobiology? We have a fully funded position in the Confinement Mechanobiology Lab designed to help you meet your career goals while researching the rapidly growing field of cellular #confinement. Please get in touch for more info!

Check out our latest paper —a new approach to pore analysis in hydrogels Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications - Tolentino - Advanced Healthcare Materials - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/full/10....

Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications

Porosity governs transport mechanics in hydrogels, yet characterization in its native state remains challenging. This work harnesses particle tracking to uncover three-dimensional pore geometric feat...

advanced.onlinelibrary.wiley.com

A great first morning session yesterday to kick off our 15th International Nanomedicine Conference. We had an outstanding talk from our first plenary speaker, Chris Porter, and our keynote and invited speakers.

Day 2 of our International #Nanomedicine Conference. We kicked off with a great plenary from Kate Schroder showcasing her work on #inflammasomes. Followed by more fantastic talks. #drugdelivery #biosensors @mknanomedicine.bsky.social @kriskilian.bsky.social @yingzhu.bsky.social

Hot off the press! Biomimetic Hydrogels from Mixed Gellan Gum and Tryptophan Zipper Self-Assembling Peptides | ACS Macro Letters pubs.acs.org/doi/10.1021/...

Biomimetic Hydrogels from Mixed Gellan Gum and Tryptophan Zipper Self-Assembling Peptides

Peptide self-assembly has been used to fabricate synthetic hydrogels that emulate many of the chemical and physical properties of natural hydrogels. However, these materials often lack stability for m...

pubs.acs.org

Prof Kris Kilian @kriskilian.bsky.social a SMART CRC CI & co-Director of the Australian Centre for NanoMedicine, said that he hopes the SMART CRC will provide opportunities for future projects, where ideas from the lab can become real life treatments and products. www.unsw.edu.au/news/2025/05...

UNSW and partners to receive millions to transform regenerative medicine

The University of New South Wales will be a key beneficiary of a $65 million government grant aimed at making Australia a regenerative medicine powerhouse.

unsw.edu.au

Great talks in the #cancer session at #ASBTE2025 in Brisbane by Sara Romanazzo and Bram Soliman from the Lab of @kriskilian.bsky.social on 3D tissue models for cancer-associated fibroblasts and the mimicry of cancer-cell interfaces. @asbte.bsky.social #biopolymers #hydrogels #bioprinting

I am looking forward to working with @msde.rsc.org as Associate Editor —consider submitting your latest and greatest work in molecular systems design and engineering 🧪🥼 🧫 🤩

Molecular Systems Design & Engineering@msde.rsc.org · last yr.

We are delighted to welcome Professor Kristopher Kilian (@kriskilian.bsky.social) to the Molecular Systems Design & Engineering Editorial Board as an Associate Editor!⭐ More information on Kris's research interest can be found on our webpage - www.rsc.org/journals-boo... #ChemSky 🧪

#RSCPoster gets underway in less than 4 hours over on LinkedIn. For 24 hours you can see posters from hundreds of researchers across the globe on topics from all areas of chemistry. Find out more at www.rsc.org/our-events/r...

RSC Poster: a global online poster conference

#RSCPoster is a global poster conference that brings the chemistry community together online over the course of 24 hours

rsc.org

We have been exploring polymer mechanochemistry to promote dynamic activities in hydrogel biomaterials. In this new paper, we integrated 2 responsive linkages into PEG-based hydrogels, where force and light were used as triggers to change chemistry. Check it out! pubs.rsc.org/en/content/a...

Multi-step functionalization of hydrogels through mechano- and photo-responsive linkages

Patterning soft materials with cell adhesion motifs can be used to emulate the structures found in natural tissues. While patterning in tissue is driven by cellular assembly, patterning soft materials...

pubs.rsc.org

Kicking off 2025 with a Coogee beach BBQ —great to hang out with these legends outside of the lab….maybe a new group meeting spot 🧐🏝️ 🥳

We developed a simple and effective way to instil some viscoelasticity, durability and bioactivity in PEG-based hydrogels, through inclusion of a self-assembling peptide network. These peptides are are an awesome additive to expand hydrogel functionality! 🤩 pubs.rsc.org/en/content/a...

Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network

Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and ...

pubs.rsc.org

Congrats to Dr. Vina Putra @vpmechbio.bsky.social for the publication of—not 1 but 2–of her research articles….a double header going into 2025! 🥳 Vina did a fabulous PhD between my lab and Melissa Knothe-Tate, exploring cellular mechanoadaptation

Vina Putra@vpmechbio.bsky.social · 2y ago

Kicking off the new year and my first post with a paper alert - my p PhD work is finally out in APL Bioeng! Part I is about cytoskeleton adaptation to volume-changing stress when perturbed with paclitaxel doi.org/10.1063/5.02...

Thoughtful gift from the team. What a beautiful assortment of science images 😍 #microscopy #biomaterials #happyholidays

I really enjoyed visiting Singapore this week for #ICBME2024. The meeting at #NUS had >700 delegates from >30 countries. Honoured to give a keynote in #Mechanobiology and invited talk in #TumorEngineering, but the best bit was catching up with old friends and making new ones….oh, and chile 🦀 🤤

Wonderful time at MRS 3D Bioinspired Biomaterials symposium

🚨 JOB OPENING 🚨 We are seeking a new Chief Editor for @naturesynthesis.bsky.social 🧪 📍 Beijing, New York or Shanghai 🗓️ Closing date: Dec 31, 2024 ✉️ DMs open for questions 🙏 Re-posts very much appreciated! springernature.wd3.myworkdayjobs.com/SpringerNatu... #Chemsky #Editorial #Publishing

a cartoon of two bears applying to jobs

Alt: A cartoon of a panda typing on a computer with a brown bear pacing in the background. At the top it says 'applying to jobs'.

media.tenor.com

Just arrived into Boston for #MRS2024 #MRSfallMeeting —lucky to catch the end of #ChadMirkin talk on nanoparticle superlattices

Reading the paper in Cell about how to close the scissor plots in gender representation at senior academic positions, I feel just a touch of pessimism. Having reached a level of seniority (middle management) I didn’t think I ever would, I read these great ideas wanting more, much more /1.

Closing the scissor-shaped curve: Strategies to promote gender equality in academia

Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reac...

cell.com

Calling all polymer scientists! Let’s re-find each other as people continue to migrate over! Please tag people in the comments and share! I’ll continue updating as we find more people. #polymers go.bsky.app/AgjxzFa

The Institute for Integrative Biology of the Cell (I2BC) is seeking to recruit new group leaders in cell biology. The application deadline is February 28, 2025 www.i2bc.paris-saclay.fr

I posted it on the dying bird, but the coverage of our results about disgusting 'tar balls' made international news in the past week! If you saw it where you are, let me know or post a link below! #ozchem #chemsky theconversation.com/black-balls-...

Black balls on Sydney beaches are likely ‘fatbergs’ showing traces of human faeces, methamphetamine and PFAS: new analysis

When lumps of black goop washed up Sydney’s beaches, an oil spill was the initial suspect – but a detailed chemical analysis points to sewage as the likely source.

theconversation.com

Here our News piece on the search from last week: www.uib.no/en/michaelsa...

Open Group Leader positions at the Centre

Apply before December 15 to join our team! We offer an attractive work environment to address fundamental questions in molecular, cellular and organismal biology.

uib.no

Lionel Christiaen, PhD (he/him/his)@lionlchristiaen.bsky.social · 2y ago

At the Michael Sars Centre, 📢 We are hiring Group Leaders! 🌊 Come join our team @UiB to lead innovative research in molecular, cellular and organismal biology using marine/aquatic organisms! ⌛️ Application deadline Dec. 15. Share this exciting opportunity ⤵️ tinyurl.com/4bwn8u3n @embl @EMBRC_EU