Finally out! Moderate POLRMT increase boosts mitochondrial transcription initiation and exercise capacity. Huge thanks to all co-authors, especially Maria Miranda! @lsajournal.org @i2bcparissaclay.bsky.social doi.org/10.26508/lsa...
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels
POLRMT is the sole RNA polymerase in human mitochondria, where it generates primers for mitochondrial DNA (mtDNA) replication and transcribes the mtDNA to express genes encoding essential components o...
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