Excited to share our latest study with @lobrylab.bsky.social! Using multiple AML models, we identified splicing dysregulation as a key feature of chemoresistance and relapse in AML. @institut-leucemie.bsky.social #ScienceTranslationalMedicine tinyurl.com/mt932jky

Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia

Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.

tinyurl.com

lobrylab.bsky.social@lobrylab.bsky.social · 2mo ago

Thrilled to share the publication of our latest piece of research in #ScienceTranslationalMedicine, in collaboration with and led by the amazing @labpuissant.bsky.social and Camille Vaganay. Why does acute myeloid leukemia (AML) so often relapse after chemo works at first? tinyurl.com/mt932jky 🧵

Wonderful discussion with @landau.bsky.social visiting us at @institut-leucemie.bsky.social @hopitalsaintlouis.bsky.social in sunny Paris to give an inspiring talk on cutting-edge single-cell technologies. Thank you so much Dan for stopping by and see you soon! @lobrylab.bsky.social

Wonderful time with Paolo Gallipoli from the @qmbci.bsky.social visiting us at @institut-leucemie.bsky.social to give a very inspiring seminar on the role of fatty acid metabolism in leukemia. Thank you so much Paolo and see you soon!!! @lobrylab.bsky.social

Amazing time with @marcusbuschbeck.bsky.social from @carrerasijc.bsky.social visiting us at @institut-leucemie.bsky.social to give an outstanding seminar on chromatin biology in leukemia. Thank you Marcus and see you soon!!!

The mood was defiant at many of the rallies, where chants of “Scientists will not be silenced”, “Facts over fear” and “What do we want? Peer review! When do we want it? Now!” were heard. https://go.nature.com/3F8T6FX

‘Scientists will not be silenced’: thousands protest Trump research cuts

Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.

go.nature.com

A truly depressing article in #Nature listing of all the damage done to #science in the US by the Trump administration in just one month 💔 for so many friends and colleagues there #solidarityforscience 🧪 www.nature.com/articles/d41...

▶️ Post-doctoral Fellow in Leukemia Research Saint-Louis Research Institute, INSERM U944 @LabPuissant jobrxiv.org/job/sain... ▶️ Postdoctoral position at the Children's Hospital of Philadelphia Children's Hospital of Philadelphia jobrxiv.org/job/chil... 3/4

Post-doctoral Fellow in Leukemia Research

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

Rates of #cancer in #young #adults have risen dramatically in recent years - as discussed in this article.. We urgently need to invest in #research 🧪 on early-onset cancers to understand - why? www.theguardian.com/science/2025...

Ultra-processed food? Forever chemicals? Declining birth rates? What’s behind rising cancer in the under-50s?

Research into the disease has never been more far-reaching, but there is little consensus as to what is causing the rocketing rates of diagnosis in young adults

theguardian.com

An unexpected take on how games work, what the stakes are for them, and how game designers can avoid the traps of optimization. "Optimizing Play" by Christopher Paul is available now (and in a free #openaccess edition, too!) 👉 https://mitpress.mit.edu/9780262547789/optimizing-play/