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Laura Edgington-Mitchell

@lauraem-lab.bsky.social

Head, Protease Pathophysiology Lab at the University of Melbourne

5 Posts389 Follower90 Folgt
Lauren Bird@laurenbird.bsky.social · 7mo ago

Coxiella & Leishmania both reside within a lysosome-like compartment in human cells, but appear to modulate the protease cohort in different ways. I’m pleased to share our latest story here, out this week in I&I: journals.asm.org/doi/10.1128/... @hayleyjnewton.bsky.social @lauraem-lab.bsky.social

Intralysosomal pathogens differentially influence the proteolytic potential of their niche | Infection and Immunity

Evading lysosomal degradation is of critical importance to successful intracellular pathogens. The lysosome, classically considered the waste disposal and recycling center of the cell, is a hostile en...

journals.asm.org

Amy Weeks@amyweeks.bsky.social · last yr.

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

rdcu.be

Laura Edgington-Mitchell@lauraem-lab.bsky.social · last yr.

Congrats to Anna and Marc for the publication of their review article "Nuclear Roles for Canonically Lysosomal Proteases.' Check it here: www.tandfonline.com/doi/full/10.... #LEMLab

Nuclear Roles for Canonically Lysosomal Proteases

While the cysteine proteases legumain and cathepsins have traditionally been known as “lysosomal” proteases, there is increasing evidence to suggest that they also contribute to a wide range of ext...

tandfonline.com

David Stroud@dstroudlab.bsky.social · last yr.

We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!

Cutting the diagnosis journey for children born with rare genetic diseases

Families can wait years for a diagnosis of a rare genetic disorder, but a new test can provide answers in days for a better understanding of the condition and potentially earlier treatment, finds new...

pursuit.unimelb.edu.au

Matt Bogyo@mbogyo.bsky.social · last yr.

The phase IIb results from the multi center trail of our cathepsin probe (VGT-309/abenacianine) are out. The probe met its endpoints and resulted in significant clinical events in 45% of patients. Great work by Vergent Biosciences and Dr. Sunil Singhal (UPenn). www.vergentbio.com/press-releas...

Vergent Bioscience Presents Phase 2B VISUALIZE Results Demonstrating Abenacianine for Injection (VGT-309) with Intraoperative Molecular Imaging Improved Tumor Visualization During Lung Surgery | Verge...

vergentbio.com

Lauren Bird@laurenbird.bsky.social · last yr.

We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS independent manner. A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications

The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

nature.com

Lauren Bird@laurenbird.bsky.social · last yr.

Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB. www.nature.com/articles/s41...

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications

The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

nature.com