Laura Medlock
@lauramedlock.bsky.social
Postdoc Neuroscientist at @uhn.ca & Krembil Brain Institute (Bains Lab). Comp neuro, touch, and stress/pain. 🧠🧑💻 they/them. 🔗 lauramedlock.com
Excited to be part of this 🤘
Scott Rich, Ph.D.@richcompneuro.bsky.social · last mo.Going to be in Nova Scotia for #CNS2026? Make sure you swing by the workshop I've organized with @rgast.bsky.social entitled "Neuronal heterogeneity's role in network dynamics and computation." The preliminary schedule and talk abstracts are now available! richlab.pnb.uconn.edu/cns2026/
Going to be in Nova Scotia for #CNS2026? Make sure you swing by the workshop I've organized with @rgast.bsky.social entitled "Neuronal heterogeneity's role in network dynamics and computation." The preliminary schedule and talk abstracts are now available! richlab.pnb.uconn.edu/cns2026/
Thank you for such an incredible course!!
Ann Kennedy@antihebbiann.bsky.social · last mo.Cajal Behavior summer course presentation day! After 5 days of hard work, we'll see data from student-designed projects on grooming and freezing flies, RL-learning and foraging robots, human VR exploration, and closed-loop loom escape in fish. An amazing group :)
More than 70 scientists have joined UHN’s Canada Leads initiative, a global recruitment program aiming to bring 100 researchers to Canada. The initiative is designed to shape the future of research and strengthen talent for health innovation. Read more: https://bit.ly/4w3UkIu
🎉 My final PhD paper is out in @sfnjournals.bsky.social! We modelled spinal receptive fields to explore how spatiotemporally diverse tactile stimuli are processed, what goes wrong in #allodynia, and how #spinalcordstimulation combats it. 🔗 www.jneurosci.org/content/46/1... 🧵👇
Spinal Processing of Spatiotemporally Diverse Tactile Stimuli: Computational Insights into Allodynia and Spinal Cord Stimulation
Weakening of synaptic inhibition in the spinal dorsal horn (SDH) contributes to mechanical allodynia after peripheral nerve pathology. Restoring inhibition can alleviate allodynia, whereas weakening i...
jneurosci.org
Join me this Tuesday at @kcnhub.bsky.social, where I’ll be sharing new computational insights into how the spinal cord processes complex touch—and what this reveals about allodynia and spinal cord stimulation. 🕔 Nov 25th 9:30-11am 📍 Krembil Brain Institute (@uhnresearch.ca) 🔗 tinyurl.com/287wdypa
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world! 🔗: www.nature.com/articles/s41... 📄: rdcu.be/ex8hW
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
nature.com
My first-ever 1st author paper is now on bioRxiv 🙂 www.biorxiv.org/content/10.1... Special thanks to my masters supervisor Steve Prescott! Also with @lauramedlock.bsky.social , @cdedek.bsky.social & more
Adaptation in somatosensory afferents improves rate and temporal coding of vibrotactile stimulus features
Adaptation is a common neural phenomenon wherein sustained stimulation evokes fewer action potentials (spikes) over time. Rather than simply reduce firing rate, adaptation may help neurons form better...
biorxiv.org
"Denial that certain diversities exist or banning the use of terminologies and classifications along spectrums does not negate the reality of personal identity and the underlying neurobiology". Thank you @iasp.bsky.social and @karenddavis.bsky.social 🧪#PainResearch journals.lww.com/pain/fulltex...
The value of equity, diversity, and inclusion principles... : PAIN
An abstract is unavailable.
journals.lww.com
Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...
Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use
Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...
biorxiv.org
In-depth article on chronic pain, with my friend @robgereau.bsky.social and Allan Basbaum heavily interviewed as scientists studying pain: ‘We die in pain, we don’t die of pain.’ www.nytimes.com/2025/01/12/m...
Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.
As many as two billion people suffer from it — including me. Can science finally bring us relief?
nytimes.com
Latest work out of the Prescott Lab on #pain sensitivity in different (nociceptive vs. non-nociceptive) afferents. 🔦
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y agoQuantifying the contribution of somatosensory afferent types and changes therein to pain sensitivity using transcutaneous optogenetic stimulation in behaving mice https://www.biorxiv.org/content/10.1101/2024.12.13.628414v1
Out now in @sfnjournals.bsky.social! 👋 Our latest work on #touch and vibration sensing in rodent #mechanoreceptors. A beautiful experimental and computational collaboration thanks to the whole Prescott Lab team. www.jneurosci.org/content/44/4...
Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin
Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received sc...
jneurosci.org