Lee Roberts
@leerobertslab.bsky.social
Professor of Molecular Physiology and Metabolism. University of Leeds UK. Research interests include metabolism, adipose tissue, skeletal muscle, diabetes, obesity, heart failure and exercise. Also a tired parent.
www.linkedin.com/posts/lee-ro...
The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis - Nature Communications | Lee Roberts
In our article published today in Nature Portfolio Nature Communications we return to examing the role of the myokine L-BAIBA in exercise. We find that production of this metabolite in muscle contribu...
linkedin.com
In this collaboration with @ox.ac.uk, we followed 3,600 pregnancies from early gestation to children’s 2nd birthday. Maternal disruption of fats required for brain growth early in gestation are associated with differences in neurodevelopment in children at age two. www.thelancet.com/journals/lan...
Impaired fetal brain growth and neurodevelopmental deficits at 2 years: deep phenotyping of maternal–fetal pathophysiology
We provided placental, epigenetic, and molecular characterisation of the pathophysiology underlying early fetal cranial and brain volume impaired growth, with consistency between epigenetic and metabo...
thelancet.com
We are advertising @thebhf.bsky.social funded 3-year PhD studentship position looking at adipose tissue - vascular crosstalk in obesity at @universityofleeds.bsky.social Deadline for applications is November 7th. More details in the link provided. www.findaphd.com/phds/project...
Targeting vascular disease in adipose tissue to treat metabolic dysfunction in obesity at University of Leeds on FindAPhD.com
PhD Project - Targeting vascular disease in adipose tissue to treat metabolic dysfunction in obesity at University of Leeds, listed on FindAPhD.com
findaphd.com
Congratulations to Amanda MacCannell on her Michael J Rennie Oral Communication Prize @physoc.bsky.social Physiology of Obesity: From Mechanisms to Medicine Meeting held in Nottingham. Presenting her @thebhf.bsky.social funded research.
Anna Malicka, Aysha Ali, Amanda D. V. MacCannell and @leerobertslab.bsky.social (@universityofleeds.bsky.social) explore the the inter-organ signalling mechanisms of brown and beige adipose tissue-derived metabokines and lipokines. 📜 buff.ly/isAId5k
Application of CIBERSORTx and BayesPrism to deconvolution of bulk RNA-seq data from human myocardium and skeletal muscle: Heliyon www.cell.com/heliyon/full...
Application of CIBERSORTx and BayesPrism to deconvolution of bulk RNA-seq data from human myocardium and skeletal muscle
RNA-sequencing (RNA-seq) is an important tool to explore molecular mechanisms of disease. Technological advances mean this can be performed at the single-cell level, but the large sample sizes needed ...
cell.com
Metabolite-mediated inter-tissue signalling. Led by Jane Luk & Mark Kearney @unileedsnews.bsky.social in @naturecomms.bsky.social we identify malonic acid as an IGF1R-regulated endothelial-to-adipocyte metabokine mediating adipose metabolism. Great start to 2025. www.nature.com/articles/s41...
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice - Nature Communications
Here the authors show that lowering IGF-1R levels in endothelial cells improves insulin sensitivity, boosts energy use, and supports beneficial changes in adipose tissue, offering insights into potent...
nature.com
Yesterday I had the huge pleasure of delivering my Inaugural Lecture as Professor @universityofleeds.bsky.social in front of my family, friends, colleagues and group. A huge thanks to them for making this possible. I’m excited to see what our future science holds.
Congratulations to Dr AlMutairy for her PhD viva today. Very proud. Thank you very much Dr Emer Fitzpatrick and Dr David Buckley for examining. @leerobertslab.bsky.social and @richard Cubbon co supervisors @envleeds.bsky.social @licamm.bsky.social
Congratulations to 1st year PhD students Anna Malicka and Aysha Ali and Fellow Amanda MacCannell on publication of their review in #ExpPhys on brown adipose tissue-derived bioactive metabolite interorgan signalling. #brownadipose #metabokines physoc.onlinelibrary.wiley.com/doi/10.1113/...
Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease
Adipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipos...
physoc.onlinelibrary.wiley.com
We are hiring a postdoctoral research associate in adipose tissue - cardiac crosstalk to join my lab @UoL_LICAMM @LeedsMedHealth Experience of animal models of cardiovascular disease - positive. Job description and how to apply here: jobs.leeds.ac.uk/Vacancy.aspx...
Job Opportunity at University of Leeds: Postdoctoral Research Fellow in Adipose Tissue – Cardiac Crosstalk in Cardiovascular Disease
Are you a postdoctoral researcher with a keen interest in cardiometabolic molecular physiology and metabolism in health and disease? Are you interested in how adipose tissue communicates with the hea...
jobs.leeds.ac.uk
It’s grant rejection Monday here today. All part of academic science of course, and we should normalise it, but we all know it’s disappointing. So I’m interested to know, what’s the best way people get over #grantrejection?
Sharing again as I have added a at least 20 newbies and people how I just found out were here. Just need to get that Giles Yeo over here now go.bsky.app/NRoqMvp
Starting afresh on this platform. We are a research group in the School of Medicine @universityofleeds.bsky.social our interests include #metabolism, #adipose, #muscle in a setting of #cardiometabolicdisease #diabetes #obesity #heartfailure and #exercise.
