A statement from AAAS CEO Sudip Parikh on OMB rule politicizing federal grantmaking:

Proposed changes by the Trump administration to rules that govern how federal dollars are spent "would inevitably lead to unlegislated reductions in funding and damage US leadership in science, both in academia and industry," writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/4uK0fBj

SIGN YOUR SUPPORT for the Reinstatement of the National Science Board at this link: zurl.co/UPf5g 1/3

Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...

Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases

Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific seq…

sciencedirect.com

Very happy to share this news of my election to become an #OpticaFellow. I'm grateful to my many students and mentors over the years. Happy Thanksgiving!

Optica@optica.org · 8mo ago

Meet the new #OpticaFellows! The Optica Board of Directors is pleased to announce that 121 members from 23 countries have been elected as Fellows for their outstanding contributions and service to Optica and the community. Find the full class: https://bit.ly/4rgXHtn

Happy to share our recent review in @natphoton.nature.com on #singlemolecule #orientation #localization #microscopy, co-authored with Sophie Brasselet @cnrs.fr @institutfresnel.bsky.social. See molecule motions and rotations in action! doi.org/10.1038/s415... @washuengineers.bsky.social @washu.edu

Single-molecule orientation and localization microscopy - Nature Photonics

The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.

doi.org

Congratulations to Brian Sun @brian_smtt, who was awarded a 2025-26 #WashU #ISP fellowship! @washumedicine.bsky.social @washuengineers.bsky.social @washu.edu

Thx again ‪@joshtpm.bsky.social‬ for sharing to our feed...THIS is the critical data needed to fuel our fight to stop Trump regimists from killing millions of American w/ their criminal cuts to agencies like #CDC. zurl.co/uJUDQ Fight back with us here zurl.co/TLiCg #StandUpForScience #SaveCDC

The CDC Data Project

In the proposed FY26 budget, programs that help Americans live safer, healthier, longer lives are on the chopping block.

cdcdataproject.org

Big shout out to rising M4 and CWRU MSTP student Eshan King - whose paper came out in @aaas.org Science Advances. connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco @cbo.bsky.social @sandyanderson.bsky.social www.science.org/doi/10.1126/...

Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy

Computational and experimental studies of drug resistance evolution give insights into why some bacteria become resistant.

science.org

"A new polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM), coupled with engineering insights provided by its imaging model, offers an exciting way forward." Matt's commentary is online in PNAS doi.org/10.1073/pnas...

We will be at “ #Optica Biophotonics Congress: Optics in the Life Sciences” in Coronado, CA, tomorrow! Yiyang and Matt will be speaking in the #Superresolution (NM1C) session on Monday morning, April 21, in the Aurora room. www.optica.org/events/congr...

A wonderful collaboration between us, @rohitpappu68.bsky.social and the Knowles lab is now online, exploring anisotropies of molecules at the interfaces of RNA condensates! Congratulations Nadia, Mina, and Yuanxin! @washuengineers.bsky.social @washu.bsky.social

Rohit V. Pappu@rohitpappu68.bsky.social · last yr.

We investigated the interfacial orientations of scaffold molecules vs. adsorbents in model condensates formed by pairs of RNA molecules with PEG. Experiments identify purine-rich RNAs as scaffolds & pyrimidine-rich RNAs as adsorbents that undergo wetting transitions. www.nature.com/articles/s41...

TO THE AMERICAN PEOPLE #sciencesky www.nytimes.com/interactive/...

Read the Letter

Researchers at academic institutions nationwide say that U.S. science is being dismantled.

nytimes.com

Nice coverage of our recent #PhysicalReviewLetter by @shawnballard.bsky.social "In molecular imaging, details matter" @washuengineers.bsky.social engineering.washu.edu/news/2025/In...

In molecular imaging, details matter

Matthew Lew and Yiyang Chen developed a new method to improve precision in molecular imaging

engineering.washu.edu

This semesters Biophysical Evening seminar will be given by Matthew Lew, Professor in Electrical & Systems Engineering at WashU "Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights" Thurs, March 20th 4-5 PM, Connor Auditorium

"Single-flurogen" is key, allows them to view condensate hubs that are normally a needle in a haystack to find. The use of a single chemical probe means they don't get conflicting signals. 🧪 www.nature.com/articles/s41...

Single-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates - Nature Physics

Experiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules.

nature.com

With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids www.nature.com/articles/s41...

Label-free Single Molecule Sensing -- the first conference in this Gordon Research Conference series. Outstanding distinguished invited speaker program just announced: www.grc.org/label-free-s... Submit your applications early! #singlemolecule #labelfree

Happy to share #YiyangChen17 's article in #PhysRevLett! What happens when you use a #polarization #microscope to look at a pair of molecules? They look like a #wobbling #singlemolecule! No 🔬 can tell the difference! doi.org/10.1103/Phys... @washu.bsky.social @washuengineers.bsky.social

In this Q&A, we asked why they organized Stand Up for Science. Here are the answers: www.nature.com/articles/s41... @leslie-bern.bsky.social @emmalovesscience.bsky.social @cdelawalla.bsky.social @jpflores.bsky.social @samschuelstein.bsky.social @standupforscience.bsky.social

Why we organized ‘Stand Up For Science’ - Nature Human Behaviour

In the USA, the Trump administration has signed executive orders that impose censorship on key areas of scientific research, strip government scientists of their jobs and reduce federal funding for sc...

nature.com

Scary statistics: Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research theconversation.com/fake-papers-...

Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research

‘Paper mills’ are contaminating the world’s scholarly output with fake papers that hinder research. Lifesaving biomedical fields are especially hard hit.

theconversation.com

Merry Christmas! Our newest review of #singlemolecule #orientation localization microscopy is now online in #qrb. doi.org/10.1017/S003... We hope it is useful to users and technologists alike! @washu.bsky.social #WashU

“I look forward to continuing my career as a perpetual student.” Portrait of Nobel Laureate W.E. Moerner for the @nationalacademies.org #NewHeroes

Getting started #singlemolecule go.bsky.app/CteFZM5

Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1

Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1

Amyloid-beta (A{beta}42) aggregates are characteristic signatures of Alzheimer's disease, but probin

biorxiv.org