@khallaf.bsky.social et al. have ID'ed a chemical signal that is key to maintaining the highly structured social organization of naked mole rat colonies: isopropyl myristate (IPM). They used whole 🧠 c-FOS imaging to show that IPM activates neurons in the olfactory bulb. 📖 bit.ly/4z14OKd

How do we balance pleasure and pain to make complex decisions? In a new paper from Steve Ramirez’s lab, Albit Caban et al. found that neurons in the prelimbic cortex (PL) play a key role in producing adaptive behaviors to resolve conflicts: bit.ly/3RFacSl @okaysteve.bsky.social @albitc.bsky.social

Yellow blood vessels (CD31) and magenta nerve fibers (NeuN) form an intricate web in this cleared intact mouse retina, imaged with #DALISPIM at 15X magnification. Sample courtesy of the Zarkada Lab at the University of Connecticut. #MicroscopyMonday

How did vertebrates evolve kidneys? Pascal Schmidt et al. used #SmartSPIM light sheet microscopy to visualize kidney development in the catshark by mapping expression of the early pronephric marker gene PAX2, revealing a somitic origin: www.science.org/doi/full/10....

Unraveling the origin of the vertebrate kidney: Emergence from a somitic compartment

The pronephros evolves from a somitic compartment in early vertebrates.

science.org

This #MicroscopyMonday video shows whole-mount acetylated tubulin staining in a stage E10 mouse embryo, cleared with SmartBatch+ and imaged with DALISPIM as part of @mblscience.bsky.social's Embryology course. Thanks Paul Maier for the sample! #DevBio

First data set collected at #Sample2Image #EMBO by @lifecanvastech.bsky.social SmartSPIM team rocking Oeiras PT

For #AlzheimersAwarenessMonth, we’re highlighting how 3D spatially-resolved data can help us understand the biology of neurodegeneration, enabling earlier diagnoses and interventions. 🧵 (1/4)

🔬 For #3DThursday: a whole cleared mouse embryo imaged with DALISPIM from @lifecanvastech.bsky.social A theme from #FOM2026 + #ELMI2026 was that light microscopy innovation can come from rethinking imaging geometries, in this case an open-top inverted #lightsheet. 🎬: #syGlass v2.6.0

Bring a little #MicroscopyMonday to your YouTube recommendations. We'll be sharing new light sheet data, old favorites, free webinars, and more to our channel. Let us know what you want to see! Subscribe to stay in the loop: youtube.com/@lifecanvast...

How can the relationship between #Alzheimers pathology & sleep quality help us diagnose & treat the disease at earlier stages? Nicholas Constantino et al. used LifeCanvas whole 🧠 mapping to uncover a key role for microglia in amyloid-related sleep disruption: bit.ly/4vR6BPy @macauleylab.bsky.social

We think #lightsheet microscopy can be more flexible, more scalable, & more intuitive. Meet up with @edwardlachica3.bsky.social at #ELMI2026 next week to learn about our light sheet systems & our sample-to-data approach! 🔬🇵🇹 @ppbioimaging.bsky.social @eurobioimaging.bsky.social @eulimi.bsky.social

📽️ SYFP2 expression data from Dr. Tanya Daigle & Emily Kussick, imaged with #SmartSPIM!

allen institute@alleninstitute.org · 2mo ago

Spinal motor neurons in dazzling detail. ✨🧠 Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of spinal cord neurons. In diseases like #ALS, they are selectively damaged, making them of special interest to neuroscientists. 🔗 https://bit.ly/4anj19z #SciShots

Also incredibly honored that our image was selected as the cover art for this issue. We used viral tracing and whole-brain light sheet microscopy to map the brain-wide collateral targets of primary somatosensory cortex neurons that project to the insula.

SfN Journals@sfnjournals.bsky.social · 2mo ago

This Week in The Journal #JNeurosci | Exploring Backpropagating Signals in Foveal Cones; Why Do Cochlear Implants Lead to Residual Hearing Loss? https://www.jneurosci.org/content/46/22/etwij46222026

Really excited to finally have this paper published 🎉🎊. A true team effort spanning many years and multiple lab members. Special thanks to former MS student Amanda Salazar for launching the project and current PhD student Tatiyana Adkins for leading the final push. Proud of everyone who contributed!

SfN Journals@sfnjournals.bsky.social · 2mo ago

#JNeurosci: Adkins et al. explored how binge alcohol exposure and protracted abstinence impact the S1-insular circuit in mice, revealing how alcohol can reshape sensory processing to drive alcohol use disorder-related behavior. https://doi.org/10.1523/JNEUROSCI.1588-25.2026

We got to introduce the LSFM community to #DALISPIM light sheet imaging at @mdibl.org last week! The excitement was palpable as we had a packed demo schedule, with students getting to see firsthand how easy DALISPIM is to use. #MicroscopyMonday

How can we get gene therapies to the heart more safely & effectively? 🫀 A research team led by Daniel Siegwart & Eric Olson at the UT Southwestern Medical Center has developed optimized lipid nanoparticles (LNPs) that demonstrate robust, targeted mRNA delivery & therapeutic potential 🧵 (1/3)

Calling all SmartBatch+ users! Have you validated a new antibody or tissue type? Send us proof and receive: 👉 15% off your next reagent order for 1 new validation 👉 25% off for 2+ validations 👉 A chance to be featured in our User Newsletter 📆 Submit your data by June 17th: bit.ly/4ekYzsj

The quality of your #lightsheet microscopy data is directly dependent on how your sample was prepared. This video shows a general comparison of some popular #tissueclearing methods, followed by Clear+ results from several mouse tissue types. Questions? Email us at info@lifecanvastech.com!

If you're going to LSFM at @mdibl.org next week, you can check out DALISPIM in person and get a hands-on demo! @lsfm-na.bsky.social

LifeCanvas Technologies@lifecanvastech.bsky.social · 2mo ago

What tissue type do you study? DALISPIM makes lightsheet imaging simple + scalable for... 🧫 Organoids and other NAMs 👥 Human clinical tissue samples 🐁 Rodents and other animal models These were all imaged directly in multiwell plates, with no sample transfer or immersion baths! #FluorescenceFriday

What tissue type do you study? DALISPIM makes lightsheet imaging simple + scalable for... 🧫 Organoids and other NAMs 👥 Human clinical tissue samples 🐁 Rodents and other animal models These were all imaged directly in multiwell plates, with no sample transfer or immersion baths! #FluorescenceFriday

A new study from @steinmetzneuro.bsky.social's lab dissects the neural circuitry of context-dependent responses – like deciding what to do during a fire drill vs a random fire alarm – honing in the role of a region called the midbrain reticular formation (MRF). (1/3) 🧵

Today's #FluorescenceFriday comes from @mblscience.bsky.social’s Embryology course last summer! This 🐢 embryo was cleared by students w/ SmartBatch+, labeled with acetylated tubulin, and imaged by MBL scientists Paul Maier & @carsten-wolff.bsky.social on a #MegaSPIM light sheet microscope.

Hello from the last day of CAN-ACN in Montreal! 🇨🇦 We've had a jam-packed week at @canacn.bsky.social's annual meeting, including checking out the Neural Circuits & Behavior satellite event hosted by @markcembrowski.bsky.social & @franklandlab.bsky.social.

The lab of Dr. Michelle Bedenbaugh studies neural circuits that drive eating, stress responses and other motivated behaviors, including how individuals choose between satisfying hunger and fulfilling other needs. #MBI_Labs @drmbede.bsky.social Learn more: www.bedenbaughlab.com

How do you use c-FOS and other neural activity markers in your research? What if that data were brain-wide and spatially resolved? Check out these studies to see how scientists are using LifeCanvas whole-brain c-FOS mapping to drive their investigations. 🧵 (1/5) #neuroscience

Last week, we dove into 3D #tissueclearing and #lightsheet imaging with researchers at Brigham & Women's Hospital. Thanks @chasjennings.bsky.social & Lai Ding for hosting us at the NeuroTechnology Studio! Want to host a LifeCanvas workshop at your core? ✉️: bit.ly/4aiXQng

Happy #MicroscopyMonday! Today we're highlighting new findings from Conor Liston’s lab at Weill Cornell Medicine that can help us improve non-pharmacological treatments for depression. Read on to learn more... (1/5) 🧵 Check out the paper: www.cell.com/cell/abstrac...

We're excited to share 3D whole-brain data at the 19th Annual Meeting of @canacn.bsky.social! Come chat with us at Booth # 5 to learn how our #spatialbiology pipeline can bring a new dimension to your #neuroscience research. Schedule a meetup: lifecanvastech.com/lets-meet-up/

How does the cerebral cortex form connections with other parts of the CNS? This #SmartSPIM data again comes from @shreyasms.bsky.social, this time showing projections of ET neurons from the visual cortex to different parts of the 🧠. Read the paper to learn more: bit.ly/48YsZxn #FluorescenceFriday

Missed our webinar? You can now watch it on demand: bit.ly/4cSM2vy The sneak peek below is from Dr. Hsuan Lee's intro to the #DALISPIM open-top #lightsheet microscope. DALISPIM makes your 3D imaging workflow easy and scalable, allowing seamless high-res data capture from up to 96-well plates.