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Long COVID Signal

@longcovidsignal.bsky.social

Tracking the latest Long COVID research so you don't have to.

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Long COVID Signal@longcovidsignal.bsky.social · 5h ago

Night shift workers had 88% higher risk of persistent symptoms vs day workers in a Spanish population cohort over 2 years. Chronic insomnia raised risk 42%; combined night work + insomnia showed 2.7x higher risk. (n=1,899) #LongCovid

Night work, sleep disruption and long-COVID risk: a population-based cohort study - PubMed

Our findings from a large prospective cohort indicate that night shift work and poor sleep are independently and jointly associated with a higher risk of long-COVID.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 6h ago

8-week tele-rehab did not improve functional mobility vs usual care in a mostly non-hospitalised RCT. Pain, health status, fatigue, and breathlessness improved. 39% could not progress exercises; no serious adverse events. (n=132) #LongCovid

Tele-rehabilitation for individuals with long COVID: a randomised clinical trial - PubMed

In the context of limited evidence around exercise in non-hospitalised individuals with long COVID, our study offers important insights into feasibility, safety and clinical relevance.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 8h ago

Three symptom clusters identified: "brain fog," "persistent acute," and "undifferentiated." 44% of the brain fog cluster reported not working, with ~half attributing absence to symptoms. Single-site cross-sectional study. (n=273) #LongCovid

Post-Acute COVID-19 Symptoms Clusters and Work Status - PubMed

Long COVID affects an estimated 10-20% of SARS-CoV-2 survivors with heterogeneous, multi-system symptoms persisting for months to years, contributing to significant workforce disruption and reduced functional capacity. This exploratory study identified symptom clusters following SARS-CoV-2 infection …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 20h ago

Cognitive deficits persisted up to 3 years post-infection, with scores 7-17 points below expected levels across most domains. 75-78% exceeded mental fatigue thresholds at 36 months. Daily functioning barriers remained in longitudinal follow-up. (n=82) #LongCovid

Neuropsychological consequences three years post-covid-19 are persistent and have great impact on everyday activities - PubMed

Post-COVID-19 cognitive dysfunction and fatigue remain prevalent for up to three years post-infection, particularly affecting attention, processing speed, and working memory. These deficits pose substantial barriers to daily functioning and return to work, highlighting the need for targeted rehabili …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 21h ago

Rehab programs improved short-term exercise capacity (~102m gain on 6-min walk test) and reduced breathlessness and anxiety vs usual care. No significant long-term effects found in pooled analyses, per systematic review and meta-analysis. (n=1,403) #LongCovid

Rehabilitation in long COVID: a systematic review and meta-analysis - PubMed

Rehabilitation programmes yielded short-term benefits in exercise capacity, dyspnoea and anxiety. Evidence for long-term efficacy remains limited and inconsistent. Further high-quality, follow-up studies are needed to determine the durability of these effects in people with long COVID.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · yesterday

Olfactory bulb shrinkage appeared across post-COVID, migraine, and chronic sinus disease groups vs controls on MRI, but its link to smell function differed by condition. Post-COVID uniquely showed a negative link between bulb width and smell performance. (n=88) #LongCovid

Comprehensive MRI analysis of olfactory bulb morphology and olfactory sulcus depth in chronic rhinosinusitis, migraine, and post-COVID patients - PubMed

OB atrophy was present across patient groups, but its relationship with olfactory function differed by condition. While OB volume remains a sensitive marker, additional measures such as width, shape, and OS depth provide complementary insights. Structural alterations may reflect underlying olfactory …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

In TB-exposed populations in Peru, 41% reported persistent symptoms, most commonly neurological and musculoskeletal. No association detected between TB disease and symptom prevalence. Quality of life worsened post-infection in this cross-sectional study. (n=99) #LongCovid

Prevalence of Long COVID in Mycobacterium tuberculosis- exposed groups - PubMed

LC prevalence in Peru aligns with global trends, underscoring significant health burdens. Those with LC reported high levels of musculoskeletal and neurological symptoms, highlighting the need for long-term follow-up and larger studies in different geographic settings to dissect the impact of TB com …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

Self-reported working memory problems were far more common than deficits on standardized cognitive tests in patients with persistent cognitive complaints. Anxiety and depression linked to more self-reported — but not objective — deficits. (n=129) #LongCovid

Subjective and objective working memory deficits in the post-acute phase of COVID-19 in a clinical trial population - PubMed

In this selected clinical trial population of individuals with persistent self-reported cognitive difficulties following COVID-19, subjective WM deficits were more frequent than objective WM deficits. The findings reveal a low association between subjective and objective WM deficits in the post-acut …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

No marked organ deficits found across brain, heart, lung, kidney, or exercise capacity vs three control groups in UK case-control study. Only vascular differences emerged: ~2x higher odds of elevated blood pressure, rising to ~3x in those with fatigue. (n=349) #LongCovid

Multi-organ structural and functional deficits in association with long COVID: a population-based case-control study - PubMed

Jointly funded by the National Institute for Health and Care Research and UK Research and Innovation (CONVALESCENCE, COV-LT-0009, MC_PC_20051).

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

Immunoadsorption did not reduce symptoms vs sham in a blinded crossover trial. No meaningful difference on fatigue, cognition, or grip strength scales despite successful autoantibody removal. (n=40) #LongCovid

Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial - PubMed

Ministry of Health, state of Rhineland-Palatinate; Mainz University Medical Centre; DIAMED Medical Technology. Trial Registration: ClinicalTrials.gov, number NCT05841498.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

Heart transplant recipients on immunosuppressive therapy showed no increased persistent symptom burden compared to cardiomyopathy controls. Prospective survey-based study found similar prevalence across groups after adjusting for baseline differences. #LongCovid

Long COVID sequelae in heart transplant recipients - PubMed

Post acute sequelae of SARS-CoV-2 infection (also known as Long COVID) have been defined as symptoms that persist after 3 months from initial acute episode of COVID-19. While the pathophysiology and mechanisms that cause Long COVID are hypothesized as secondary to persistent inflammation and immune …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

Infection linked to higher risk of all six allergic conditions studied — asthma, eczema, food allergies, rhinoconjunctivitis, medication allergies, and hives — over 18 months. Propensity-matched retrospective cohort of children and adults ages 1–64. #LongCovid

Post-COVID-19 onset of allergic conditions in a propensity-matched cohort of children and adults - PubMed

This study adds to the growing body of evidence illustrating the risk of developing allergic conditions after COVID-19 infection in both children and adults. Our findings highlight the potential public health burden of these conditions, emphasize the importance of monitoring for allergic diseases af …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2d ago

Symptomatic vs asymptomatic post-infection individuals had lower breathing muscle endurance, reduced lung ventilation and perfusion, and worse sleep quality. Breathing fatigue index strongly correlated with lung ventilation (r=0.93) in cross-sectional study. (n=33) #LongCovid

Inspiratory muscle fatigue and pulmonary deposition/perfusion imaging predict sleep dysfunction in long COVID: Evidence from MTC scintigraphy and FIT performance metrics - PubMed

Long COVID is associated with reduced inspiratory muscle performance, impaired ventilation/perfusion, and worse sleep, supporting FIT and pulmonary scintigraphy as potential functional markers for assessment and rehabilitation monitoring.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 5d ago

Pre-infection vaccination linked to lower risk of persistent symptoms in children and adolescents, especially smell/taste dysfunction, nausea, and hair loss. Case-control study during Omicron wave in Sapporo, Japan. #LongCovid

Post-COVID-19 Conditions and Vaccination in Children and Adolescents during the Omicron Outbreak: A Case-Control Study in Sapporo, Japan - PubMed

Persistent symptoms attributed to post-COVID-19 conditions were more frequent among COVID-19-positive individuals, especially smell and taste dysfunction. Vaccination before infection was associated with a lower risk of post-COVID-19 conditions, particularly smell/taste dysfunction, nausea, and hair …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 5d ago

Blood-particle RNA panel distinguished ME/CFS from idiopathic chronic fatigue and depression with 87% sensitivity and 94% specificity in initial testing. Four top-ranked markers were elevated vs healthy controls in case-control study. (n=24) #LongCovid

Circulating extracellular vesicles-microRNAs as potential biomarkers for the identification of ME/CFS: differentiating fatigue-related conditions - PubMed

A 62 EV-miRNA signature provides insight into the interconnected neuro-systemic pathways disrupted in ME/CFS, particularly those governing neuronal connectivity and cellular scaffolding. Within this candidate EV-miRNA signature, the top-ranked miRNAs-miR-21-5p, let-7f-5p, miR-26b-5p, and miR-20a-5p- …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 5d ago

Losartan plus prednisolone for 16 weeks did not significantly improve heart pumping function vs placebo in patients with cardiac inflammation. Treatment was safe and well-tolerated in this double-blind RCT. (n=279) #LongCovid

Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial - PubMed

Persistent cardiac symptoms are common in post-COVID syndrome, even without structural heart disease. Evidence implicates immune dysregulation, endothelial dysfunction and low-grade cardiovascular inflammation. Yet no targeted treatment exists. Myoflame-19 is a multicenter, double-blind clinical tri …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 6d ago

Elevated inflammatory markers and ICU admission during hospitalization linked to impaired lung function and reduced walking capacity post-recovery. Disease severity and CT classifications did not predict functional outcomes in this retrospective study. (n=101) #LongCovid

Association of laboratory and radiological findings during hospitalization with early post-COVID pulmonary function and exercise capacity: a retrospective study - PubMed

Elevated inflammatory markers and ICU admission during hospitalization were associated with impaired pulmonary function and reduced exercise capacity in the early post-COVID period. In contrast, disease severity and CO-RADS classification were not predictive of functional outcomes. These findings hi …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 6d ago

CD8+ killer T cells remain cytolytic and exhausted vs recovered controls, targeting both SARS-CoV-2 and reactivated herpesviruses. Observational study found this effect especially prominent in women, suggesting a failure to resolve acute immune activation. #LongCovid

Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID - PubMed

Viral-specific CD8<sup>+</sup> T cells play roles in protective immunity and immunopathology including during COVID-19. Leveraging combinatorial tetramers, we profiled CD8<sup>+</sup> T cells specific for SARS-CoV-2, as well as those for cytomegalovirus (CMV) and Epstein-Barr virus (EBV)-herpesvirus …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · last wk.

Neither multi-organ MRI nor digital rehabilitation reduced fatigue beyond usual multidisciplinary care at 12 weeks. All groups improved by ~4.5 points on a fatigue scale, with no significant differences between arms in English NHS clinics in cluster RCT. (n=1,152) #LongCovid

Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial - PubMed

Combining multidisciplinary care plans into integrated care pathways (ICPs) is scalable, generalizable and effective for several long-term conditions, but not evaluated in Long COVID (LC). Our phase 3, cluster-randomized, multicenter clinical trial investigated the effectiveness of ICP interventions …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · last wk.

Wearable heart rate variability was lower in patients vs healthy controls during daily activities, exercise, and sleep. Autonomic recovery after exercise remained impaired for 24 hours, linking post-exertional malaise risk to overexertion in observational study. #LongCovid

Wearable Heart Rate Variability Monitoring, Autonomic Dysfunction and Post-exertional Malaise in Long COVID: An Observational Study - PubMed

These results confirm the applicability of wearables to assess autonomic function and manage overexertion in patients with long COVID.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · last wk.

ADDRESS-LC is a phase 2 triple-blind trial testing bezisterim, an oral anti-inflammatory that crosses the blood-brain barrier, for brain fog and fatigue. 20 mg twice daily vs placebo for 12 weeks across US sites. (n=208) #LongCovid

ADDRESS-LC: study protocol for a phase 2, triple-blind, randomised, placebo-controlled trial to evaluate the efficacy and safety of bezisterim (NE3107) in adults with long COVID - PubMed

NCT06847191.

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · last wk.

Higher general stress linked to more symptoms and higher diagnostic odds in U.S. mothers of young children. Social support modified stress-symptom links in complex ways; childcare stress effects did not survive multiple comparison correction. (n=2,508) #LongCovid

Stress, social support, and long COVID diagnosis and symptom burden in women - PubMed

Stress is meaningfully linked to long COVID risk, symptom number, and duration among women, but associations vary across outcomes and are modified by different types of social support. Differentiating perceived and diagnosed long COVID revealed potential inequities in illness recognition. Findings u …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2w ago

Only 17% of initial responses to an online patient survey were retained after screening for bots and fraud. Key defenses: removing incentive mentions, avoiding public social media recruitment, and monitoring response timing across Canada, Ireland, UK, and US. (n=798) #LongCovid

Battling the Bots and Defending Against Fraudulent Responses in an International Community-Engaged Web-Based Survey With People Living With Long COVID: Methodological Study - PubMed

Our lessons learned fell into the following three areas: (1) survey-design and implementation to prevent and identify fraudulent and bot-generated responses, (2) recruitment strategies to mitigate the risk of disruption by bots, and (3) responding to disruptions caused by fraudulent and bot response …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2w ago

EHR-based machine learning algorithm identified highly symptomatic patients with 80% accuracy vs self-reported symptoms in RECOVER cohort. Top predictive features: fatigue, shortness of breath, cardiac rhythm diagnoses, and use of albuterol, gabapentin, or duloxetine. #LongCovid

Characterization and Validation of EHR Computable Phenotypes for Long COVID Using Patient-Reported Symptoms: Insights from the Nationwide RECOVER Program - PubMed

These findings demonstrate that, using EHR data, a machine-learning model can accurately select patients with sets of self-reported LC symptoms. The model could help identify patients within a health system with the highest probability of the condition and facilitate screening, recruitment for clini …

pubmed.ncbi.nlm.nih.gov

Long COVID Signal@longcovidsignal.bsky.social · 2w ago

Four symptom questionnaires (post-exertional malaise, cognition, autonomic, orthostatic) were generally understood and relevant in a cognitive debriefing study. Participants flagged cognitive burden and suggested simplifying and shortening surveys. #LongCovid

Item comprehension and content coverage of patient-reported outcome measures for long COVID: a qualitative study - PubMed

Based on the overall support for comprehension and relevance of items within each measure, use of these measures within the Long COVID clinical trial platform was generally supported. Future work, including qualitative and quantitative studies, could improve the experience of PROM data collection in …

pubmed.ncbi.nlm.nih.gov