Thrilled to share a new preprint from the lab, showing that active fork slowing and reversal is not confined to the damaged subnuclear compartment but rapidly extends throughout the nucleus, via non-canonical ATR signaling and modulation of MRN exonuclease activity. www.biorxiv.org/cgi/content/...

Non-canonical ATR signalling via NBS1 phosphorylation propagates fork slowing from stressed to unperturbed nuclear regions

DNA replication forks frequently encounter obstacles and remodel into four-way junctions to actively slow DNA fork progression. Fork slowing can also spread to undamaged forks via an ATR-dependent mec...

biorxiv.org

Don't miss the next GiiN seminars tomorrow (June 9th). Just click here at 17.00h CET 👇 uzh.zoom.us/j/6598481621...

TODAY! Don't miss it 👇

Here is the full 2026/27 program of @genomeiinetwork.bsky.social virtual seminars, chaired by myself and @dimiccolab.bsky.social. Scan the QR code to receive alerts and automated calendar. Don't miss a bunch of exciting talks from established and emerging leaders in genome integrity world-wide!

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

TODAY! 👇

Lopes_Lab@lopeslab.bsky.social · 5mo ago

Two more upcoming GIIN virtual seminars you should not miss! Just connect to the Zoom link below on March 3rd, 5pm, CET 👇

Two more upcoming GIIN virtual seminars you should not miss! Just connect to the Zoom link below on March 3rd, 5pm, CET 👇

Tomorrow (Tue 3rd)! PLEASE NOTE THE ALTERNATIVE ZOOM LINK! 👇

Don't miss the opportunity to attend exciting virtual talks from leading scientists in genome integrity, provided by the @genomeiinetwork.bsky.social! Next one is in a few days 👇

GIIN@genomeiinetwork.bsky.social · 6mo ago

Another great science appointment is coming up with @nitikataneja.bsky.social and @doksanilab.bsky.social! Join us live on Tuesday, February 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F...

TODAY! 👇

Lopes_Lab@lopeslab.bsky.social · 7mo ago

One more upcoming appointment with great science via the Genome Integrity Italian Network (GiiN). Don't miss it, just join via the link 👇

One more upcoming appointment with great science via the Genome Integrity Italian Network (GiiN). Don't miss it, just join via the link 👇

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

rdcu.be

TODAY! Don’t miss it! 👇

Lopes_Lab@lopeslab.bsky.social · 8mo ago

In a few days we'll have our last appointment (for this year) with great virtual talks via the GiiN. Please note in agenda and join us with a click! 👇

We will be collecting applications for one more week (Dec 5th), then proceed shortlisting candidates for the next “SNSF starting grant” deadline (May 2026). Please hurry up sending your docs and/or spread the news! (…and mind the “Swiss link” in the eligibility criteria) 👇

Lopes_Lab@lopeslab.bsky.social · 11mo ago

New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇 www.imcr.uzh.ch/dam/jcr:3d1f... www.imcr.uzh.ch/en.html

In a few days we'll have our last appointment (for this year) with great virtual talks via the GiiN. Please note in agenda and join us with a click! 👇

Happy to have contributed to this interesting study from penengolab.bsky.social! another interesting example of how chromatin modifications and their readers orchestrate replication fork plasticity and protection 👏👇

The EMBO Journal@embojournal.org · 9mo ago

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA @penengolab.bsky.social and collaborators www.embopress.org/doi/full/10....

One more opportunity in a few days (Nov 4th), to attend two great 30' talks online! 👇

New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇 www.imcr.uzh.ch/dam/jcr:3d1f... www.imcr.uzh.ch/en.html

Tomorrow (Tue 9th) at 5 PM CET. Don't miss it!

Lopes_Lab@lopeslab.bsky.social · 12mo ago

Mark your calendar (September 9th) for two more exciting virtual seminars of the Genome Integrity Italian Network (GiiN). Full schedule for the Fall season also provided just below. No registration required, just come and join us with a click! 👇

Mark your calendar (September 9th) for two more exciting virtual seminars of the Genome Integrity Italian Network (GiiN). Full schedule for the Fall season also provided just below. No registration required, just come and join us with a click! 👇

One more appointment with great science in a few days, one click away 👇

Exciting PhD project available in our lab (time sensitive)! 👇

Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)

GIIN@genomeiinetwork.bsky.social · last yr.

The Genome Integrity Webinar Series continues on Tuesday, May 6th at 5PM (Rome) / 11AM (New York) with an exciting discussion on DNA damage response and repair @kajastelab.bsky.social Join via Zoom: uniroma1.zoom.us/j/95149984403

More exciting genome integrity research at the horizon. Register to receive alerts and marks for your calendar 👍👇

GIIN@genomeiinetwork.bsky.social · last yr.

We thank @martakova.bsky.social and Mate Maus for sharing their research with our community at yesterday's seminar! Our next seminar on Tuesday, May 6th will feature @kajastelab.bsky.social and Raphael Ceccaldi. Subscribe here to receive the reminder: t.co/Hv6iLmjlly

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

Just landed back in the lab, after a few incredible days on the Alps! A wonderful opportunity to consolidate our projects, rethink our strategies, explore new ideas, blend as a team... and, above all, have a lot of fun! Proud of you guys... and certainly much stronger now! 👍🤩

a great conference, and a tribute to a great scientist and man 👇

Jihane Basbous@jihanebasbous.bsky.social · 2y ago

Dear Colleagues, We are extending our early bird registration deadline to December 17th as there have been some issues both with the Carte Achat service as well as with the website. All have now been sorted.We look forward to seeing you for this special event that will honour the memory of Angelos.

Landing on Bluesky by sharing the latest preprint from the lab: nucleoplasmic Lamin A/C modulates RECQ1-mediated fork restart upon mild genotoxic stress, by regulating heterochromatin marks and ADP-ribosylation levels at replication factories www.biorxiv.org/content/10.1...

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Mild replication interference is a consolidated strategy for cancer chemotherapy. Tolerance to mild replication stress (RS) relies on active fork slowing, mediated by transient fork reversal and RECQ1...

biorxiv.org