PLRC is wrapping up our summer fundraiser and want to thank everyone who has supported so far! There's still time to give. Your support helps us continue addressing the #LongCovid questions patients care most about. Donate: patientresearchcovid19.com/donate/
PLRC is continuing our summer fundraiser to help sustain our work and fund new projects that will improve clinical trials and biomarkers! You can help us by donating, sharing our posts, & forwarding emails you receive to folks in your network 🧵 Donate: patientresearchcovid19.com/donate/
PLRC is kicking off a summer fundraiser to help sustain our work and fund new projects that will improve clinical trials and biomarkers! You can help by donating, sharing our posts, and forwarding the emails you receive to folks in your network.🧵 Donate: patientresearchcovid19.com/donate/
"One of the more exciting themes to emerge recently in the #MECFS and #LongCovid fields – a new confidence that researchers will be able to pluck out biologically defined subsets that can be targeted with the drugs."
Hitting the Target? ME/CFS and long COVID T-Cell Researchers on Uncovering the Precise Drivers of the Illnesses - Health Rising
Dr. Selin and company believe they can solve one of the key mysteries of ME/CFS and long COVID: exactly why the T-cells are getting pummeled.
healthrising.org
"As any good vicious circle will do, T-cell exhaustion only makes things worse. Having a major pathogen fighter offline could give.. other viruses the opportunity to reactivate. The immune system responds by trying to activate T-cells more, leaving them more exhausted than ever."
Hitting the Target? ME/CFS and long COVID T-Cell Researchers on Uncovering the Precise Drivers of the Illnesses - Health Rising
Dr. Selin and company believe they can solve one of the key mysteries of ME/CFS and long COVID: exactly why the T-cells are getting pummeled.
healthrising.org
"Dr. Selin’s group started a T-cell exhaustion discussion in #MECFS that has only grown over time. They’ve found multiple lines of evidence... indicating that not only have the cytotoxic T-cells in these diseases become exhausted but there are fewer of them as well."
Hitting the Target? ME/CFS and long COVID T-Cell Researchers on Uncovering the Precise Drivers of the Illnesses - Health Rising
Dr. Selin and company believe they can solve one of the key mysteries of ME/CFS and long COVID: exactly why the T-cells are getting pummeled.
healthrising.org
Great article on a PLRC-funded project! "Her idea has, over time, become a familiar one: an infection which the body failed to clear or deal with properly has left one of the big guns of the immune system–the cytotoxic T-cells–in a state of chronic activation." @cortjohnson.bsky.social #LongCovid
Hitting the Target? ME/CFS and long COVID T-Cell Researchers on Uncovering the Precise Drivers of the Illnesses - Health Rising
Dr. Selin and company believe they can solve one of the key mysteries of ME/CFS and long COVID: exactly why the T-cells are getting pummeled.
healthrising.org
.. from large, randomized trials might support regulatory licensure. Negative results can reveal unforeseen safety issues. In some cases, even negative studies can help identify subgroups of patients" Full paper: www.thelancet.com/journals/ecl...
"Testing more disease-modifying treatments can have major scientific and social value at this time. Positive results from small, proof-of-concept trials can provide the rationale to conduct larger trials and attract much needed private investment in #LongCovid. Positive results..
"Because research budgets are limited, it is ethically imperative to optimize the scientific and social value of funded research. In our view, a pivot to more, well-designed, trials of disease-modifying treatments for #LongCovid follows from this imperative"
"While the pathophysiology of #LongCovid remains incompletely understood, the knowledge gained has helped identify possible disease-modifying treatment targets, including several types of immunomodulatory, neurological, antiviral and other drugs"
New paper in @thelancet.com ft. PLRC member Dr. Megan Fitzgerald (@themegascope.bsky.social): "In this paper, a group of bioethicists, clinician-scientists and people.. with #LongCovid argue that it is ethically imperative to conduct trials of disease-modifying treatments for LC now." 🧵
The next phase in Long COVID research: addressing the ethical challenges in trials of disease-modifying treatments
Almost five years after COVID-19 emerged, multiple scientific uncertainties remain about why some people experience ongoing symptoms long after being infected with SARS-CoV-2 (Long COVID). The pathoph...
thelancet.com
🔥Levinovitz's article is a firestorm of conflation & misrepresentation He tries to reframe the community as toxic gatekeepers, whilst claiming there is a treatment but THEY are keeping it from you. Classic grift It's time to stop blaming patients' fear as being the problem
Long Covid Advocacy (@longcovidadvoc.com)
🧵OF KEY CONCERNS We've now read Alan Levinovitz's WIRED piece on Long Covid. Our concern isn't that it discusses psychological theories. Our concern is that it repeatedly conflates criticism of…
bsky.app
ok the more I stare at the image of zero studies, the angrier I am. Wired, are you for real? Did you not check for a single study in a reputable journal, first? You're advertising snake oil to desperate people on what? a whim? I assumed a study had come out, at least, even if it was very poor.