P-bodies rapidly remodel in response to ER stress—before stress granules form—to preserve selected mRNAs via the ATF4–Bruno 1 pathway during Drosophila oogenesis. @thegraduatecenter.bsky.social www.life-science-alliance.org/content/9/10...

“Life Science Alliance is recognized globally as a respectable journal. Within the community, it stands out for its focus on scientific integrity, ensuring that robust data is shared globally.” — Jérémie Rossy, University of Konstanz. Learn more: hubs.ly/Q04ldCnb0

This study identifies R7 as a promoter-proximal element that supports JAG1 transcription by coordinating local chromatin contacts and regulatory features. www.life-science-alliance.org/content/9/10...

Check out this interesting article recently published in LSA: "Fishing with Two Lines: A Hybrid Approach to Spatial Transcriptomic Discovery" www.life-science-alliance.org/content/9/10...

This study identifies CpG islands at 3′UTRs as highly conserved, frequently methylated, and linked to cancer-related gene regulation. @kanherelab.bsky.social www.life-science-alliance.org/content/9/10...

Take a look at this Resource paper in our Genetics, Genomics, and Epigenomics collection: Predicting Nonsense-mediated mRNA Decay from Splicing Events in Sepsis using RNA-Sequencing Data www.life-science-alliance.org/content/gene...

Our August issue is here! Discover a new mechanism for degrading extracellular proteins, how T cells decide to arrest at their targets, and a novel link between mitochondrial protein MIRO1 and glioma. www.life-science-alliance.org/content/9/8

Take a look at this article in LSA: RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation www.life-science-alliance.org/content/9/10...

Check out this interesting article recently published in LSA: "Lack of evidence for transcription-to-RNA maturation lags across G1/G2 phase boundary in fibroblasts" @cincychildrens.bsky.social @cincykidsheart.bsky.social www.life-science-alliance.org/content/9/10...

Transcriptomic profiling of cortical nuclei identifies neuron-specific RNA catabolic pathways during torpor and non-neuronal seasonal adaptations in the Djungarian hamster. @manuelfriese.bsky.social www.life-science-alliance.org/content/9/10...

Technical proof-of-concept study demonstrating the hybridization and co-detection of both low- and high-plex probe chemistry on a single Xenium spatial transcriptomics slide with 17 hLung samples. www.life-science-alliance.org/content/9/10...

🧬 EPAS1 variants help shape hypoxia adaptation in the subterranean rodents Eospalax and Spalax, shedding light on the genetic mechanisms that enable life in low-oxygen underground environments. #Evolution #Hypoxia #Genetics www.life-science-alliance.org/content/9/9/...

Not all CpG islands are at promoters! 🧬 ~3% lie in 3'UTRs-highly conserved, often methylated & linked to cancer pathways. This study suggests a potential role in gene regulation. @kanherelab.bsky.social www.life-science-alliance.org/content/9/10...

Check out this paper in our Genetics, Genomics, and Epigenomics collection: Efficient Identification of de novo Mutations in Family Trios: A Consensus-Based Informatic Approach www.life-science-alliance.org/content/gene...

RAFTER combines an RNA editing enzyme with a translation termination factor to selectively label translated RNAs, enabling accurate and scalable translation profiling with single-cell compatibility. www.life-science-alliance.org/content/9/10...

In human fibroblasts, transcription and RNA accumulation are temporally concordant across the cell cycle, challenging the model of extensive transcription-to-maturation lags during the cell cycle. @cincychildrens.bsky.social @cincykidsheart.bsky.social www.life-science-alliance.org/content/9/10...

EPAS1 reveals convergent hypoxia adaptation in subterranean rodents: Chinese zokors carry a stabilizing T480S variant, while Israeli blind mole rats show regulatory changes linking hypoxia and interferon pathways. www.life-science-alliance.org/content/9/9/...

👉 SATB1 preserves CD4⁺ T cell fidelity and establishes Treg function in anti-tumor immunity www.life-science-alliance.org/content/9/10...

Check out this interesting article recently published in LSA: The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation www.life-science-alliance.org/content/9/10...

“The reviewers provided constructive, relevant feedback that strengthened our manuscript, and the editorial team was supportive.”— Jérémie Rossy, University of Konstanz. Learn more about publishing in LSA: hubs.ly/Q04ldCnb0

Targeted smn-1 silencing in C. elegans caused distinct defects and differences in sensitivity between neurons of the same class. We present a robust framework to dissect the mechanisms underlying selective neuronal vulnerability of SMA. www.life-science-alliance.org/content/9/9/...

Septin7 is essential for hematopoietic stem cell development but dispensable for cytokinesis in myeloid and lymphoid progenitors. Moreover, it is not required for lymphoid development under either steady-state conditions or oncogenic stress. www.life-science-alliance.org/content/9/10...

Epigenetic liquid biopsies reveal endothelial turnover and erythropoiesis in asymptomatic COVID-19 in our Genetics, Genomics, and Epigenomics collection www.life-science-alliance.org/content/gene...

Have you already seen our Cancer Biology Collection www.life-science-alliance.org/content/canc... and read this paper? www.life-science-alliance.org/content/9/2/...

Extended therapeutic inhibition of CDK4/6 pushes cancer cells into a senescent-like state and can trigger NF-κB activation to induce an inflammatory signature in both liposarcoma and ER+ breast cancer cells. www.life-science-alliance.org/content/9/9/...

Upstream regulators of membrane repair in response to pore-forming toxins are poorly understood. Data here support Vav2 acting in annexin, MEK, and dysferlin-mediated repair www.life-science-alliance.org/content/9/9/...

Read this paper RB dependent transcriptional regulation at mitotic centromeres preserves genome stability www.life-science-alliance.org/content/9/3/... in our Cancer Biology Collection 2026: www.life-science-alliance.org/content/canc...

SATB1 regulates FoxP3 expression, preserving lineage fidelity in conventional CD4+ T cells maintaining FoxP3 target gene repression in Tregs. Deleting SATB1 disrupts Treg function, unleashing potent anti-tumor immunity. www.life-science-alliance.org/content/9/10...

In a male rat model of metabolic syndrome, renal denervation before the high-fat diet has only a transient effect, suggesting that hypercaloric diet-induced endocrine changes trigger hypertension independently of renal sympathetic activity. www.life-science-alliance.org/content/9/10...

Take a look at this Methods paper recently published in LSA: DiffMethylTools:a toolbox of the detection, annotation and visualization of differential methylation www.life-science-alliance.org/content/9/9/...