Disease genes are evolution's map to what matters. In our new paper in Brain, we use one — the autism & epilepsy gene PTEN — to ask how a neuron controls its own growth. The answer points to a single, druggable culprit: AKT. 🧵🧠

We generated a podcast detailing our latest manuscript, in press, at Brain. Its relatively technical. Should I make a less technical version? Yay or nay on Ai podcasts? youtu.be/cz3jBRWexhQ?...

AKT is Necessary for Neuronal Hypertrophy and Epilepsy Caused by Pten KO

YouTube video by Bryan Luikart

youtu.be

A renaissance in targeting the PI3K/AKT/mTOR pathway www.nature.com/articles/s41... rdcu.be/faYxr This new Perspective discusses how advances in understanding of PI3K signalling in disease and novel pharmacological strategies are revitalizing interest in targeting the pathway

I have decided to embrace blue sky. I never really played too much on twitter, but I did like # fluorescence friday. And I also really like talking about science so I am starting to play with blue sky. May the bot onslaught of why science doesnt matter never find me. #neuroscience #PTENPathway