L Brielmaier
@lynnbr2.bsky.social
Electronics Engineer who has ALS. Member IEEE Brain, EMBS,iBCI-CC.org. Designed & built a custom AI LLM capable AAC eye gaze computer. BCI candidate to drive my exoskeleton. Python noob. Interested in EAPs. #MedSky
FDA allows unique endpoint in rare disease study www.pharmavoice.com/news/fda-uni... via @PharmaVoice Using hospitalization as a primary outcome measure is another demonstration of regulators granting flexibility in clinical trial design for rare diseases.
FDA allows unique endpoint in rare disease study
Global regulators are allowing the company to use hospitalization as the primary efficacy endpoint in its registration trial for a rare neuromuscular disorder.
pharmavoice.com
The Senate passed their version of ACT for ALS last night! We are one step closer to reauthorizing the most historic piece of ALS legislation ever written What's next? The House will be back in session in September For now: Thank your lawmakers! bit.ly/A4A-TY
Thank you for passing ACT for ALS! - I AM ALS - ALS is Relentless. So Are We!
Thanks to the work of the entire ALS community, the House of Representatives and Senate voted to reauthorize the ACT for ALS. This is a huge win for everyon ...
bit.ly
#DingDingDing I’m a neurologist. I’ve delivered ALS diagnoses. Then I received one myself www.statnews.com/2026/08/03/a... via @statnews.com
I’m a neurologist. I’ve delivered ALS diagnoses. Then I received one myself
“Losing the ability to speak has taught me how quickly society conflates physical dependence with diminished personhood,” writes Dr. Christopher Campos.
statnews.com
Their findings reveal a role for TDP-43 in regulating the TREM2-DAP12 axis in mice, highlighting a previously unrecognized mechanism through which TDP-43 controls microglial function. www.nature.com/articles/s41...
Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice - Nature Neuroscience
Compagnion et al. show that TDP-43 loss in microglia causes myelin defects, oligodendrocyte precursor cell imbalance and motor deficits in mice. They identify TDP-43 as a regulator of the TREM2-DAP12 ...
nature.com
The Writer and Workplace Intelligence report found that 44 % of Gen Z workers and roughly a third of the broader work force said they were actively sabotaging their company’s A.I. rollout. The fear is real, & it is spreading. The way out of this is not more hype. www.nytimes.com/2026/08/03/o...
Opinion | I Helped Run Lululemon. The A.I. Revolution Is a Hot Mess. (Gift Article)
The A.I. revolution is stalling because companies don’t want to admit that integrating the technology is expensive and slow and requires human effort.
nytimes.com
Early-onset sleep alterations found in patients with ALS are ameliorated by orexin antagonist in mouse models | Science Translational Medicine www.science.org/doi/10.1126/... early stages of ALS without respiratory impairment (i.e. before) show altered sleep macroarchitecture.
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models
In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.
science.org
Clinical Long-Read Genome Sequencing for Rare-Disease Diagnostics | New England Journal of Medicine cheap and effective www.nejm.org/doi/full/10....
Clinical Long-Read Genome Sequencing for Rare-Disease Diagnostics | NEJM
In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing.
nejm.org
“Our study looked at the rates of ALS among people in different branches of the U.S. military and found ALS rates varied considerably by branch and rank, with larger differences among younger veterans.” www.medlink.com/news/in-us-v...
In US veterans, rates of ALS associated with military branch and rank | MedLink Neurology
Compared to Army veterans, men who are veterans of the U.S. Air Force, Navy and Coast Guard have higher rates of amyotrophic lateral sclerosis, and men…
medlink.com
Range Rover's Electrostatic Sound System Sets Audio Standard The $12,570 audio upgrade for the Range Rover uses 21 thin-film transducers that respond 1,000 times faster than conventional speakers for unmatched clarity. And without rare Earth magnets. www.designnews.com/automotive-e...
Range Rover Electrostatic Sound System Review
Range Rover's electrostatic speakers deliver audio quality that surpasses all previous automotive sound systems available
designnews.com
How your next stove could save you money — and upgrade the electric grid A new generation of home appliances promises to cut energy bills and make the electric grid cleaner. wapo.st/4bOXDL7
Column | How your next stove could save you money — and upgrade the electric grid
A new generation of home appliances promises to cut energy bills and make the electric grid cleaner.
wapo.st
You've Heard of Cyclospora. What Other Parasites Can You Catch From Food? www.medpagetoday.com/publichealth... One unique example is T. gondii, which is "possibly the most successful parasite on the planet,"
You've Heard of Cyclospora. What Other Parasites Can You Catch From Food?
Experts describe some of the most common protozoa and worms
medpagetoday.com
To everyone : Subject: Fw: Updated invitation: Party with Lynn B! @ Sat Aug 1, 2026 9am - 10:30am (PDT) (lynnbr2@att.net) A Virtual Vacation because I don't get out much, but I'm still here! 11:00 CT, 12:00ET start Please invite others, if you wish Lynn Brielmaier, us06web.zoom.us/j/8180678824...
Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise cloud communications.
us06web.zoom.us
A cancer diagnosis may not be enough: Trump and Democratic states clash in court over who’s too sick to work Medicaid eligibility will soon hinge on how the government defines “medical frailty.” www.politico.com/news/2026/07...
A cancer diagnosis may not be enough: Trump and Democratic states clash in court over who’s too sick to work
Medicaid eligibility will soon hinge on how the government defines “medical frailty.”
politico.com
Resmed ventilator safety issue linked to 5 serious injuries www.medtechdive.com/news/resmed-... via @MedTechDive Enters a "fail-safe" mode that can kill people. Go figure.
Resmed ventilator safety issue linked to 5 serious injuries
The supply of the circuit boards needed to fix the devices is significantly constrained, preventing the company from immediately correcting all affected ventilators.
medtechdive.com
Copilot is on the benign side. www.nytimes.com/2026/07/23/t...
How to Use ChatGPT and Gemini Prompts to Find Out What They Know About You (Gift Article)
It can be unsettling what Gemini and ChatGPT have figured out about you and how easily your privacy can be punctured. Here’s how to find out.
nytimes.com
A Device Hidden in Cars Across the US Leaves Them Vulnerable to Hacking and Paralysis. Patch It Now Dealerships installed alarms in millions of vehicles—and left them in even if the buyer didn’t want them. And they can be hacked to unlock, track, and disable cars. www.wired.com/story/a-devi...
A Device Hidden in Cars Across the US Leaves Them Vulnerable to Hacking and Paralysis. Patch It Now
Dealerships installed alarms in millions of vehicles—and left them in even if the buyer didn’t want them. Now researchers warn they can be hacked to unlock, track, and disable cars.
wired.com
The ‘lost art’ of Yordan Alvarez: a stone-faced superstar www.nytimes.com/athletic/740... I love this guy! Homered in the first inning just now. Followed up with a double.
The 'lost art' of Yordan Alvarez: a stone-faced superstar
nytimes.com
The chemical makes its way into our brains through our blood, which it enters primarily when we breathe in dust particles laden with 6PPD-Q. Other exposures include crops and soil, stadium turf, working near highways or with cars, and contact with recycled tire products. futurism.com/health-medic...
Learning What Substance Is Suspected of Causing Alzheimer's May Throw You Into an Existential Crisis
A surprisingly common substance was found to have a causal relationship with the kind of brain damage associated with Alzheimer's disease.
futurism.com
Since the mobile internet comes with a far more expensive data tariff, every gigabyte now matters more than ever. www.makeuseof.com/turned-off-w...
I turned off these Windows apps before using my mobile hotspot and saved 3GB in a day
My Windows OS seems to think all internet comes with unlimited data. These settings force it to behave
makeuseof.com
I have an IG account, but I don't use it much. As part of Meta’s Muse Image model rollout, Instagram users with public accounts need to opt out to block AI generations of their content. Without any notice. www.wired.com/story/meta-n...
Meta Now Lets Anyone Use Your Instagram Photos in AI Images—Unless You Opt Out
As part of Meta’s Muse Image model rollout, Instagram users with public accounts need to opt out to block AI generations of their content.
wired.com
A soft-hand exoskeleton that anyone can afford medicalxpress.com/news/2026-07...
Special glove helps people with paralyzed hands grasp objects
The Technical University of Munich (TUM) has developed a soft, pneumatic glove that restores the ability of people with paralyzed hands to grasp objects. To achieve this, researchers at the TUM Chair ...
medicalxpress.com
AI company Anthropic announces it will begin developing drugs of its own www.statnews.com/2026/06/30/a... via @statnews.com We’ve decided to start running some drug programs & we’ve chosen to do this by running drug programs in the pre-clinical stage … and choosing indications for neglected disease
AI company Anthropic announces it will begin developing drugs of its own
AI giant Anthropic has already become a dominant player in technology and a household name for everyday users of artificial intelligence. Can it make drugs too?
statnews.com
