CISTR-ACT was the 1st lncRNA involved in inter-chromosomal contacts and in Mendelian disease (brachydactyly). We now revealed CISTR-ACT’s molecular mechanism: tinyurl.com/CISTR-ACT, @sickkidsto.bsky.social, @uoftpress.bsky.social, @natcomms.nature.com, @natureportfolio.nature.com

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

tRNA-overlapping long non-coding RNA loci repress codon-biased genes

Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions interact between chromosomes and depend on each other’s transcription. tROL perturbations silence codon-biased genes i...

tinyurl.com

Register now and see you soon in Mexico for a great conference and speaker line up!

Fusion Conferences@fusionconf.bsky.social · 11mo ago

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️https://bit.ly/3JJzYR4

Finally, the Maass lab is on #Bluesky and seeks science skeets and news! More on lncRNAs and trans-chromosomal contacts (kissing chromosomes / non-homologous chromosomal contacts [NHCCs] soon. Refreshing some older news: www.nature.com/articles/s41...

Inter-chromosomal contacts demarcate genome topology along a spatial gradient - Nature Communications

The authors develop a supervised and unsupervised learning algorithm Signature. Machine learning and network model analysis of Hi-C datasets across 62 2n genomes suggest that inter-chromosomal contact...

nature.com