MAGIC researcher Leah Zerlin recently presented on advanced 2D and 3D iPSC-derived models of X-linked myotubular myopathy at the 2026 Muscle Stem Cells and Regeneration meeting. This work is helping to build robust platforms for the development of future treatments ✨ #MAGIC #MuscleResearch

Proud to see #MAGIC partner @genethonfr.bsky.social presenting at #SITGEC2026 in Milan! Highlights included a presentation on gene editing for DMD treatment by Dr Mario Amendola, alongside a poster on CRISPR-mediated utrophin upregulation as a mutation-independent strategy for DMD 💡

#FlashbackFriday to meeting our new MAGIC consortium partner, Optics11 Life! Duchenne Parent Project Italy and @mdukcharity.bsky.social heard about their technology and how it fits into the MAGIC project. Plenty of enthusiasm to see what we can achieve together! #RareDisease #HorizonEurope

Join MAGIC partner Optics11 Life alongside @axolbio.bsky.social & @kingscollegelondon.bsky.social on 16 July (16:00 CET) to explore the move from 2D cardiomyocytes to predictive 3D cardiac models with the Cuore platform. Register: www.optics11life.com/resources/we... #CardiacResearch #MAGIC

From 2D cardiomyocytes to 3D functional insights

Elevate your research with the Cuore Muscle-on-a-Chip platform! Join Dr. Mohammad Khoonkari as he introduces Cuore V2, a pioneering tool in 3D muscle tissue contractility and high-throughput functiona...

optics11life.com

We're excited to welcome Optics11 Life, DiNABIOS and HOYA Consulting to the MAGIC consortium! Their expertise in mechanobiology and disease modelling will strengthen our next phase of research and translation. Welcome aboard! #HorizonEurope #RareDiseases

Meet the people behind MAGIC 🎥 This intro video highlights some of the researchers and industry partners working across the MAGIC consortium - bringing together expertise from academia and industry to tackle shared challenges and create new opportunities through collaboration. #MAGICConsortium

MAGIC members on tour! 👀 MAGIC members DINAMIQS joined the Cell & Gene Meeting on the Med to discuss gene therapy discovery and commercialisation. Great discussions on how early CDMO involvement can help speed up development and get innovative therapies to patients sooner ✨ #GeneTherapy #MAGIC

Sneak Preview! ✨ Something special is coming soon... Stay tuned as we begin sharing short interviews from our 4th General Assembly Meeting with some of our Senior and Junior Magicians, that offer a glimpse into the people behind our MAGIC Horizon community in the coming weeks! 🎥

We are wrapping up at the 4th MAGIC Horizon Project General Assembly in San Sebastián (1–2 June 2026). There has been great progress across the consortium with valuable discussions on future experiments, sustainability and collaboration. Thank you to VIVEbiotech and all partners! #HorizonEurope

Activating the body's backup plan in DMD 👀 At ASGCT 2026, INSERM presented CRISPR-based work in DMD - aiming to switch on utrophin through epigenetic regulation, sparking discussion on mutation-independent strategies and gene regulation tools for muscular dystrophies. #ASGCT26 #GeneTherapy #MAGIC

⚡ Calcium signalling links stimulation to muscle contraction. This clip shows real time calcium transients in engineered muscle using Fluo 4. These functional readouts are central to MAGIC as we move toward disease models and gene therapy testing. #CalciumSignalling #LiveCellImaging #MAGIC

🔬 A closer look at one of our 3D muscle constructs after 14 days in culture. Confocal imaging reveals organised muscle fibres, nuclei, calcium release channels, and mitochondria – key features we check before modelling disease or testing therapies. #Microscopy #MuscleResearch #MAGIC

🧬 In MAGIC, we’re building 3D muscle models that closely mimic human tissue. These engineered fibres align, mature, and contract in response to stimulation – providing a powerful system for testing gene therapies in disease relevant muscle. #3DMuscle #GeneTherapy #MAGIC

🚀 New MAGIC paper! A mutation‑independent CRISPR–Cas9 edit boosts utrophin in human DMD cells, 3D muscle, and mdx mice — improving calcium handling, contraction, and muscle pathology. A promising universal approach alongside dystrophin‑restoring therapies. pubmed.ncbi.nlm.nih.gov/41877484/

We’re adding lay summaries of recent MAGIC conference presentations to our website to make our work more accessible to the neuromuscular community. These short overviews share the key ideas, aims and insights behind the science across the network. Check them out: magic-horizon.eu/project-reso...

AAV gene therapies can only progress if we can manufacture high‑quality vectors at scale. MAGIC and DINAMIQS have been working to make AAV production more robust and development‑ready, helping ensure emerging neuromuscular therapies have a practical path toward the clinic. #GeneTherapy #AAV

For #RareDiseaseDay we're highlighting the importance of equity in rare disease research and care. MAGIC partners have shared what motivates their work and how they hope to help create a fairer future. Read their words here: magic-horizon.eu/news/rare-di...

This year's JP Morgan Conference highlighted a growing focus on smart manufacturing choices in CGT. MAGIC members DiNAMIQS met with teams to discuss how strong science can be turned into scalable therapies—supporting MAGIC’s mission to advance treatments for rare neuromuscular conditions.

🧬 The past year has seen huge progress across MAGIC — from refining 3D muscle constructs to expanding engineered tissue and multi‑organoid platforms. These advances are giving us more predictive ex vivo models and helping accelerate the path toward next‑gen gene therapies. #MAGICProject

Great to see the MAGIC consortium highlighted in UCL’s story on accelerating therapies for rare neuromuscular disorders. Collaboration across Europe is essential to driving the breakthroughs patients need. 🌍✨ #MAGICconsortium #RareDisease #NeuromuscularResearch

UCL News@uclnews.bsky.social · 6mo ago

UCL has joined the DREAMS consortium - a major @horizoneu.bsky.social funded collaboration using AI, cutting edge lab techniques and stem cell research to speed up the discovery of therapies for rare neuromuscular disorders #UCLEurope www.ucl.ac.uk/news/2026/ja...

Earlier this month, MAGIC members took part in the ESGCT Academy. PhD students presented projects linked to MAGIC and received feedback and career advice. The event also showed the depth of our expertise, with speakers supporting the next generation of researchers. #genetherapy #research

Where is MAGIC? Across Europe and beyond. Our consortium spans 10 countries, connecting leading institutions to tackle neuromuscular research challenges together. 🔗 magic-horizon.eu #MAGICProject #ResearchCollaboration #NeuromuscularResearch

ICYMI: What’s next for neuromuscular treatment development? MAGIC Project joined Muscular Dystrophy UK's Muscles Matter podcast to discuss SMA gene therapies, AI, and the future of collaborative research. 🎧 Listen: bit.ly/4aJpPodcast #MAGICProject #GeneTherapy #Podcast

🎆 Happy New Year from the MAGIC Project! 🎆 In 2026, we’ll keep pushing boundaries in neuromuscular research: ✅ Better disease models ✅ Gene therapy innovation ✅ Stronger networks for translation Learn more: magic-horizon.eu #MAGICProject #HappyNewYear

Recent advances have changed the landscape, but what’s next for neuromuscular treatment development? MAGIC joins Muscular Dystrophy UK's Muscles Matter podcast to discuss progress, research priorities & the role of AI. 🎧 Listen: www.musculardystrophyuk.org/support/serv...

Muscular Dystrophy UK podcast: Muscles Matter - Muscular Dystrophy UK

This series is informed by insights from our community about what you want to listen to – themes that span from health and wellbeing, the latest research, tips and advice on day to day living with a m...

musculardystrophyuk.org

Explaining gene therapy isn’t easy – but it’s essential. Francesco Saverio Tedesco from the MAGIC project shares a clear way to make it understandable for patients. Learn more about MAGIC’s patient-centred approach: magic-horizon.eu/about/object... #GeneTherapy #MAGICHorizon

Missed our latest newsletter? It was a BIG one including conference highlights, progress and our general assembly! Stay in the loop: 🔗 Sign up today ➡️ magic-horizon.eu/news-events/newsletter

🔬 Curious about the latest progress in gene therapy for muscular dystrophies? The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community. 🧬 Explore open-access papers, abstracts, and key findings here: 👉 magic-horizon.eu

Last month, MAGIC partners met in Lisbon for our annual General Assembly at GIMM. Discussions focused on: • Improving AAV delivery for gene therapy • Gene editing beyond mutation correction • 3D muscle models to accelerate testing Read more: magic-horizon.eu/news/magic-g...

✨ What is MAGIC and why does it matter for gene therapy? PI @SaverioTedesco shares how this multi-partner project tackles key challenges in rare neuromuscular conditions – building building tools for safer, more effective treatments. 🎥 Watch below #GeneTherapy #RareDisease