Mahul Chakraborty

@mahulchak.bsky.social

https://chakrabortylab.org/

Recent work from the lab. Even after hundreds of generations of intense directional selection at relatively small Ne, substantial genetic variation persists, and can be rapidly redeployed when the direction of selection reverses. Results are suggestive of balancing selection. doi.org/10.1093/molb...

Beyond Fixation: Persistent Genetic Variation Under Intense Selection

Abstract. Understanding how and why genetic variation is maintained under sustained selection remains a central question in evolutionary genetics. Experime

doi.org

Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...

Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS

In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...

pnas.org

M

The centromere performs an essential function during cell division, yet its DNA sequence can evolve remarkably rapidly—a puzzle known as the centromere paradox. How can function remain conserved when sequence does not? 🧵 1/4

How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...

piRNA loss unleashes episodic transposition bursts

In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon ex...

biorxiv.org

M

What can undergraduate classroom research teach us about a decades-old genetics problem? A lot, as it turns out. Proud of the tremendous work by @alesamano.bsky.social and our undergraduate researchers. A great example of discovery-driven learning in action. artsci.tamu.edu/news/2026/07...

Texas A&M Undergraduate Study Reveals Effects of Large DNA Changes

Researchers found that major changes in DNA were connected to a surprisingly large number of harmful traits in fruit flies.

artsci.tamu.edu

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Among all the recognitions I’ve received, this one holds a special place. I dedicate it to my teachers, mentors, and students. Grateful to the Dept of Biology @ Texas A&M for the freedom to build an ambitious undergraduate genomics program, and to the College of Arts & Sciences for the recognition.

Bild

1/12 Excited to share our new paper. Many essential functions, like DNA packaging and chromosome integrity, are encoded in highly repetitive, "recalcitrant" parts of the genome. But these regions have been incredibly hard to study. Until now. genome.cshlp.org/content/35/9...

Genetic variation in recalcitrant repetitive regions of the Drosophila melanogaster genome

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

M

🚨multiple tenure-track jobs Our department at @tamu.bsky.social is hiring multiple tenure-track faculty. Two of these will be in Evolutionary Biology/Genetics. Please apply or share it with anyone looking for a TT position! I'll be happy to answer questions. faculty.tamu.edu/JobDetail?Jo...

Faculty Job Board

In support of growth in the Biological Sciences, major remodeling of teaching space is presently underway, as is architectural design for a new Biology building that will add significant research space for our faculty.

faculty.tamu.edu

Are you interested in research in evolutionary genetics & genomics 🧬 (but maybe not ready to apply to graduate school)? Come work with me or one of my amazing colleagues at Rice University, University of Houston, or Texas A&M! Apply to our #NSF funded post-bacc research program! (Please share!)

STEGG-INTERACT@stegg-interact.bsky.social · 2y ago

The STEGG-INTERACT Research and Mentoring for Post-baccalaureates program is now accepting applications for our 2025-26 cohort! Application deadline is March 1, 2025. Program runs June 2025 - May 2026 at University of Houston, Rice University, and Texas A&M.

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Fellow #Drosophila researchers! Ever wondered about the genome sequence of your lab strain or the balancers? Check out our Drosophila Laboratory Pangenome Database, featuring a growing collection of reference genome assemblies for popular D. melanogaster strains! github.com/chakrabortym...

GitHub - chakrabortymlab/DLPD: code and scripts relevant to the Drosophila Laboratory Pangenome Database

code and scripts relevant to the Drosophila Laboratory Pangenome Database - chakrabortymlab/DLPD

github.com