A brain-penetrant P2X7R antagonist mitigates Alzheimer’s disease pathology www.biorxiv.org/content/10.64898/2026.04.06.716621v1 #cryoem

Excited to share our latest preprint on bioRxiv! www.biorxiv.org/content/10.6... An international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine. Grateful to everyone involved in making this work possible!

link.growkudos.com/1eub610y1hc

Molecular Structures of the Hearing Loss Associated Human P2X2 Receptor

ATP is best known as the “fuel of the cell,” providing energy for nearly every biological process. But when ATP is released from cells, it takes on a very different role — acting as a danger signal th...

link.growkudos.com

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoEM

Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists: urldefense.com/v3/__https:/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social

Subtype-specific structural features of the hearing loss-associated human P2X2 receptor pubmed.ncbi.nlm.nih.gov/40938707/ #cryoEM

Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket. www.pnas.org/doi/10.1073/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social

A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM

The KCVI research retreat was a great success this year. Very happy to participate. Looking forward to making this an annual event!

OHSU Surgical Data and Decision Sciences Lab@ohsusurgdata.bsky.social · last yr.

A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM

Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing. If you are interested, please watch a recording of his seminar, linked here: youtu.be/IdcoLJc7X8M

March 27, 2025: Adam Oken, Oregon Health and Sciences University

YouTube video by CryoEM Service Centers

youtu.be

A paper from our group published a couple of months ago.

UniTmp@unitmporg.bsky.social · 2y ago

Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket. @ScienceAdvence. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bqh

I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.

cryoEM papers@cryoempapers.bsky.social · 2y ago

UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design www.biorxiv.org/content/10.1101/2025.02.12.637899v1 #cryoEM