Congrats to our talented postdoc @amirbitran.bsky.social for his first preprint in the lab, a collaboration with the Bustamante lab, studying time-resolved protein folding during translation elongation with HDX-MS! Check out the attached manuscript and tutorial for more:

Amir Bitran@amirbitran.bsky.social · last mo.

I am delighted to share that my newest manuscript and the first of my postdoc in the Marqusee and Bustamante labs, “A detailed molecular picture of protein folding during active translation”, is now on the BioRXiv! (1/n) www.biorxiv.org/content/10.6...

Congrats to our very talented Joshua Morse who recently presented his undergraduate thesis, titled "HDX-MS of Disorder-Containing Complexes Probes Bound State Ensembles", and graduated from UC Berkeley MCB with honors! We are thrilled to have Josh stay in the lab for another year as a PREP scholar

A belated congrats to PhD alum, Sophie Shoemaker on her impressive paper, which recently got published in Science Advances! Sophie managed perform HDX-MS on the SARS-CoV-2 spike protein embedded into membranes in virus-like particles! A truly impressive feat. www.science.org/doi/10.1126/...

Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation

Conducting HDX-MS on SARS-CoV-2 spike-eVLPs, the effects of natural and engineered features on protein dynamics were determined.

science.org

The Marqusee lab is at BPS2026 in San Francisco! Susan gave an invited talk yesterday at the biopolymers in vivo subgroup! Today, Eva Gerber is co chairing the protein dynamics/allostery platform (4 pm rooms 204-206) and giving a flash talk as part of that session at 5:50 pm

The Marqusee lab is at the 2026 protein folding Gordon Research seminar + conference! Amir will be giving a 10 min talk at the GRS today, while Eva will give a 10 min talk at the GRC on Tuesday! Susan will serve as a panelist on today's career panel at the GRS!

Our postdoc Amir Bitran @amirbitran.bsky.social is giving a talk tomorrow at the University of Chile, hosted by Marqusee lab alum and current U. chile faculty Yito Wilson! Feel free to join the talk (which will be largely in Spanish) by scanning the QR code below

Congrats to our current postdoc Amir on his latest publication with the Shakhnovich and Rodnina labs! Check out this thread about their really interesting study, combining all-atom simulation with experiment to reveal a protein's co-translational folding pathway at an atomistic level of detail

Amir Bitran@amirbitran.bsky.social · 11mo ago

Really thrilled to share my latest co-first author publication in Science Advances, the culmination of a project from my PhD with Eugene Shakhnovich and a wonderful collaboration with the lab of Marina Rodnina www.science.org/doi/full/10....

So thrilled to share that Susan was selected as a 2025 Protein Society Fellow!

UC Berkeley MCB@berkeleymcb.bsky.social · 11mo ago

Congrats to MCB's Susan Marqusee @marquseelab.bsky.social on being selected as a 2025 Protein Society Fellow @proteinsociety.bsky.social! 👏🎉

Excited to share our latest paper led by our talented former PhD student Miriam Hood onlinelibrary.wiley.com/doi/10.1002/...

Exploring the sequence and structural determinants of the energy landscape from thermodynamically stable and kinetically trapped subtilisins: ISP1 and SbtE

A protein's energy landscape, all accessible conformations, their populations, and dynamics of interconversion, is encoded in its primary sequence. While how this sequence encodes a protein's native ...

onlinelibrary.wiley.com

Come check out presentations by the Marqusee lab at the 39th Protein Society Annual Symposium (@proteinsociety.bsky.social). Darren Kahan just gave an awesome talk on his work on IDPs.

Pleased to share a manuscript by our star former grad student, Sara Volz, showing the power of HDX-MS to probe folding intermediates of γD crystallin under native conditions. This approach could shed future light on cataract-linked aggregation. Thanks @alexguseman.bsky.social and the Gronenborn lab

Check out Sophie's new preprint on bioRxiv in collaboration with Magnus Hoffmann's lab where we conduct HDX-MS on SARS-CoV-2 spike proteins displayed on eVLPs to understand the dynamics of natural and engineered variants. 1/7 biorxiv.org/content/10.1...

The Interplay of Furin Cleavage and D614G in Modulating SARS-CoV-2 Spike Protein Dynamics

We report a detailed analysis of the full-length SARS-CoV-2 spike dynamics within a native-like membrane environment and variants inaccessible to studies on soluble constructs by conducting hydrogen-d...

biorxiv.org