Photoredox-catalyzed regioselective allene alkoxycarbonylations for the synthesis of α-allyl-γ-lactones

A dual photoredox/hydrogen atom transfer (HAT) strategy for the radical alkoxycarbonylation of allenes is described. Alkoxycarbonyl radicals, generated by photoredox-catalyzed decarboxylation of alkyl...

pubs.rsc.org

Reactivity of Anomalous Aziridines for Versatile Access to High Fsp3 Amine Chemical Space

ConspectusThe manipulation of strained rings is a powerful strategy for accessing the valuable chemical frameworks present in natural products and active pharmaceutical ingredients. Aziridines, the sm...

pubs.acs.org

Elucidating the Mechanism of Electrooxidative Allene Dioxygenation: Dual Role of Tetramethylpiperidine N-Oxyl (TEMPO)

The cumulated π system of a nonsymmetric allene contains three distinct unsaturated carbons that imbue it with unique reactivity toward radicals as compared to its alkene and alkyne counterparts. Desp...

pubs.acs.org

Bench-Stable 2-Halopyridinium Ketene Hemiaminals as Reagents for the Synthesis of 2-Aminopyridine Derivatives

2-Chloro-1-(1-ethoxyvinyl)pyridinium triflate and several other bench-stable N-(1-alkoxyvinyl) 2-halopyridinium triflates have been developed as reagents for the synthesis of valuable 2-aminopyridine ...

pubs.acs.org