My lab has been studying human genes that control infection HIV infection of CD4+ T cells for over a decade. Today we report a major milestone in Cell: www.cell.com/cell/fulltex...

Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social

GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:

Causal modelling of gene effects from regulators to programs to traits - Nature

Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

nature.com

Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...

Happy to share our latest paper in Nature Biotech, led by graduate student Laine Goudy, joint with Luke Gilbert at Arc, developing CRISPRon/off technology for epigenetic programming of human T cells.

Integrated epigenetic and genetic programming of primary human T cells

Nature Biotechnology - Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

rdcu.be