New Compass Psilocybin Ph3 readout: The question is not so much 'if' it works, but more 'how' it should be clinically implemented with repeat dosing.

New open dataset out in Scientific Data 🚨 We are releasing BBBD: the Brain, Body, and Behavior Dataset. Paper: www.nature.com/articles/s41... Work with @parralab.org

The Brain, Body, and Behavior Dataset (BBBD): Multimodal Recordings during Educational Videos - Scientific Data

Scientific Data - The Brain, Body, and Behavior Dataset (BBBD): Multimodal Recordings during Educational Videos

nature.com

We just released a major update to TDBRAIN V3.1: one of the largest and most well phenotyped, openly available clinical EEG datasets (>1500 EEGs).

Effect of pulse width and shape on transcranial magnetic stimulation induced heart-brain coupling by Zwienenberg L et al 2026 doi.org/10.1016/j.br... ⚡🧠 🧲 #TMS #BrainStim

Postitive top-line Ph3 results for Definium DT120 (LSD) in MDD. Exciting and great to see a clear signal. Response and remission rates at 35-24% however seem relative low compared to the MDD treatment landscape. I hope real-life effectiveness data will get better when integrating with psychotherapy.

Great application of Heart-Brain Coupling: Investigating effects of TMS pulse-width and pulse-shape on frontal excitability, just out in Brain Stimulation Journal. doi.org/10.1016/j.br...

Why health authorities should endorse rTMS for treatment-resistant depression. doi.org/10.1016/j.tr... Nice overview of the current evidence for both the efficacy and effectiveness of TMS in the treatment of depression.

New preprint: We investigated the safety of ibogaine in 19.071 patients across 11 international clinics and in an updated systematic review. We wanted to see if the introduction of the ibogaine safety guidelines in 2016 has made administration of ibogaine safer. Here's what we found:

Always wanted to open EDF/BDF files (EEG or ECG) on Apple or other platforms? We just released an online EDF and BDF viewer, you can open, apply filters, change montages, identify PQRST components in ECG data and save all changes and add ECG component annotations to EDF+ or BDF+ files.

Look forward presenting a keynote and workshop at ISNR conference in Las Vegas in August. Will focus on Heart-Brain Coupling and QEEG-based Stratified Psychiatry in ADHD and Depression. See you there? web.cvent.com/event/cdfcfc...

34th Annual ISNR Conference 2026

Join me for this event: 34th Annual ISNR Conference 2026

web.cvent.com

Look forward to presenting @UCLA on alpha frequency and heart-brain coupling as biomarkers for personalized TMS.

Looking forward presenting tomorrow, will bridge the gap between biofeedback and TMS-induced Heart-Brain Coupling. Online meeting, so accesible from anywhere... See you there! aapb.starchapter.com/meetinginfo....

Impressive results by AtaiBeckley re BPL-003: 76% remission after just 2 doses (8mg+12mg) after 2 mo. in Ph2B. Higher than other interventional psychiatry tx such as accelerated TMS, requiring less time.

What do we do after a patient responds to rTMS? Taper? Monthly maintenance? Wait for relapse and retreat? Just published a consensus statement (NL+Belgium) reviewing 22 studies on maintenance rTMS and combining this with clinical survey data and patient input. www.sciencedirect.com/science/arti...

Low heart-rate as a predictor for TMS response: Sometimes the simpler metric is better than the more complex metrics: No effects of complexity/non-linear HRV measures, but low heart-rate robustly predicts better response to TMS (HF and LF TMS), replicated in SAINT iTBS sample.

Complexity or simplicity? A replication analysis of low heart rate as a predictor of TMS response in major depressive disorder

sciencedirect.com

Replication of SAINT-aiTBS in depression in new double-blind study demonstrating even higher remission of 50% at 4-wks FU! onlinelibrary.wiley.com/doi/10.1002/...

Stanford neuromodulation therapy for treatment‐resistant depression: a randomized controlled trial confirming efficacy, and an EEG study providing insight into mechanism of action and a potentially predictive biomarker of efficacy

Stanford neuromodulation therapy (SNT) is a rapid-acting, high-dose, intermittent theta-burst stimulation protocol. Although it has previously demonstrated efficacy for treatment-resistant depression...

onlinelibrary.wiley.com

Just came back from Palestine and really enjoyed training the UEF teams from Betlehem and Nablus on the use of TMS in mental health. We also donated two TMS systems for use in Bethlehem and Nablus, which makes it the first TMS available in Palestine!

Whether it's clinically better than racemic MDMA I couldn't say but here is a good piece from Gill Bedi looking at what we know...

Stanford University obituary for Nolan Williams. You're missed Nolan... med.stanford.edu/news/all-new...

Just out in TMS: Here we explain in more detail the differences between NCG-TMS and Heart-Brain Coupling in response to work from Mark George's group on heart-rate as a biomarker for TMS. Together with John Coetzee and Nolan Williams doi.org/10.1016/j.tr...

We've lost a pioneer, an innovator, great mentor and friend. We'll terribly miss you Nolan...

Owen Muir, M.D., DFAACAP, FCTMSS@owenmuir.bsky.social · 10mo ago

A eulogy for my friend Nolan Williams. open.substack.com/pub/thefront...

What a great TMS Masterclass we just had, great engaging group of attendees and speakers from across the globe and learnt a lot on the latest in TMS and Brain Stimulation.

Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!

Just published: A study on the clinical effectiveness of transitioning to right lateral OFC-TMS following unsuccessful use of sequential bilateral DLPFC-TMS for major depression. Read more about the study at: doi.org/10.1016/j.tr...

Disturbed sleep is a leading symptom and likely causal factor for the development of psychiatric diseases such as mood disorders. Here we review how sleep is altered in depression, and discuss the role of sleep for therapeutic approaches: www.biologicalpsychiatryjournal.com/article/S000...

Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇

Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation

Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...

medrxiv.org

Just a handful of places still available for our TMS Certification Course and Masterclass. Hope to see you there! Sign-up here: brainclinics.com/masterclass/...

New editorial with Niels Birbaumer & Tato Sokhadze: rdcu.be/eCB 🧠 Neurofeedback & BCIs started in the 1930s, in a Wall Street tycoon’s mansion lab, and now going main stream in Silicon Valley...

TMS also stimulates the trigeminal nerve which can result in clinical benefit independent of its direct cortical stimulation. TENS sham procedures help control for these effects, however such studies should be adequately powered since some level of response to just TENS sham are expected.

Join us for the 2025 TMS Masterclass & Certification Course — taking place September 30 to October 2 in Nijmegen, The Netherlands. 📍 Don’t miss your chance to be part of it! 👉 Secure your seat now: brainclinics.com/masterclass/...