𝗜𝗺𝗮𝗴𝗲 𝗹𝗮𝗿𝗴𝗲 𝗰𝗲𝗹𝗹 𝘃𝗼𝗹𝘂𝗺𝗲𝘀 𝘄𝗶𝘁𝗵𝗼𝘂𝘁 𝘀𝗮𝗰𝗿𝗶𝗳𝗶𝗰𝗶𝗻𝗴 𝘀𝘂𝗽𝗲𝗿-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻🔬 Classical single-molecule localization microscopy (SMLM) is constrained to TIRF and HILO illumination. 𝗕𝗿𝘂𝗸𝗲𝗿 𝗩𝘂𝘁𝗮𝗿𝗮 𝗩𝗫𝗟 + 𝗠𝗮𝘀𝘀𝗶𝘃𝗲 𝗣𝗵𝗼𝘁𝗼𝗻𝗶𝗰𝘀 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀 𝗰𝗵𝗮𝗻𝗴𝗲 𝘁𝗵𝗮𝘁. www.massive-photonics.com/product-cate...

🎉 New paper alert 🎉 A Nature Methods paper from Fu et al. introduces MOSAIC, a microscope that integrates lightsheet, super-resolution, label-free, and multiphoton imaging. Congrats to all authors!! Our reagents used for DNA-PAINT imaging of lamin & TOMM20. 🔗: www.nature.com/articles/s41...

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...

nature.com

New paper alert! Le et al. introduce brightness demixing, a method that distinguishes fluorophores by their photon flux rather than spectral properties. Congrats! Authors used our #DNAPAINT reagents to image clathrin, tubulin, vimentin, & nuclear pores. 🔗 www.nature.com/articles/s41...

Brightness demixing for simultaneous multi-target imaging in 3D single-molecule localization microscopy - Nature Methods

Brightness demixing is a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on their brightness rather than their spectral properties. As this ...

nature.com

🔬 Attention ELMI2026 attendees! Join us with @oni-bio.bsky.social for multiple hands-on DNA-PAINT workshops on the Nanoimager platform. 🔗 Register here: ppbi.pt/wordpress/in... ⚠️ Limited capacity per workshop session. See you in Coimbra!! #DNAPAINT #SMLM #Superresolution #MassivePhotonics

For DNA-PAINT, Antibodies, VHHs, and other affinity binders must be conjugated to an oligo (docking strand) to enable target visualization through transient DNA binding events. We’ve developed comprehensive #DNAPAINT kits that integrate seamlessly into existing #superresolution workflows.

Struggling with background when imaging targets deep in the cell via DNA-PAINT? Fluorogenic imagers improve your results: ✔️ 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗶𝗻 𝗘𝗽𝗶, 𝗛𝗜𝗟𝗢, 𝗮𝗻𝗱 𝗧𝗜𝗥𝗙 imaging modes ✔️ 𝗟𝗼𝘄𝗲𝗿 𝗯𝗮𝗰𝗸𝗴𝗿𝗼𝘂𝗻𝗱 ✔️ 𝗛𝗶𝗴𝗵𝗲𝗿 𝘀𝗶𝗴𝗻𝗮𝗹-𝘁𝗼-𝗻𝗼𝗶𝘀𝗲 ratios Explore here: www.massive-photonics.com/product-cate...

When do custom DNA-PAINT reagents make sense? Many researchers start with our off-the-shelf #DNAPAINT kits, but sometimes as experiments evolve, they need something more tailored. 🔗 www.massive-photonics.com/service-conj...

Want to take your imaging to the nanoscale? Check out our Beginner's guide for an easy start to DNA-PAINT super-resolution microscopy! 🔗 www.massive-photonics.com/dna-paint-be... #SMLM #DNAPAINT #MassivePhotonics #Microscopy

𝗡𝗲𝗲𝗱 𝘀𝗶𝗻𝗴𝗹𝗲-𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻? Our RESI imaging kits for GFP and ALFA tagged proteins deliver. 𝗥𝗘𝗦𝗜 𝗶𝘀 𝗮 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗯𝗮𝘀𝗲𝗱 𝗺𝗲𝘁𝗵𝗼𝗱 that achieves sub-nanometer spatial-resolution in cells,for precise imaging of individual proteins (rdcu.be/eFy7c). 👉 Explore kits: massive-photonics.com/product-cate...

COMING SOON... #DNAPAINT

𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗮𝗸𝗲𝘀 𝗺𝘂𝗹𝘁𝗶-𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗶𝗺𝗽𝗹𝗲𝗿 𝘁𝗵𝗮𝗻 𝘆𝗼𝘂 𝘁𝗵𝗶𝗻𝗸🔬 In #DNAPAINT, target identity is encoded into the DNA sequence, not in the dye. That means multi-target imaging doesn’t require more optics, just buffer exchange, called Exchange-PAINT. Key advantage: huge multiplexing potential.

We’re recruiting a PhD student! 🎓Join our team as part of the 𝗠𝗮𝗿𝗶𝗲 𝗦𝗸ł𝗼𝗱𝗼𝘄𝘀𝗸𝗮-𝗖𝘂𝗿𝗶𝗲 𝗗𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗚𝗟𝗬𝗖𝗢𝗖𝗔𝗟𝗬𝗫! Your project will focus on developing 𝗹𝗲𝗰𝘁𝗶𝗻-𝗯𝗮𝘀𝗲𝗱 𝗹𝗮𝗯𝗲𝗹𝘀 𝘁𝗼 𝘃𝗶𝘀𝘂𝗮𝗹𝗶𝘇𝗲 𝗴𝗹𝘆𝗰𝗮𝗻𝘀 𝘂𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝘂𝗽𝗲𝗿-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆. ➡️ 𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲 & 𝗔𝗽𝗽𝗹𝘆: www.linkedin.com/jobs/view/43...

New paper alert! Authors introduce 𝗚𝟱𝗠, 𝗮 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧-𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗲𝗱 𝗚𝗮𝘂𝘀𝘀𝗶𝗮𝗻 𝗠𝗶𝘅𝘁𝘂𝗿𝗲 𝗠𝗼𝗱𝗲𝗹𝗶𝗻𝗴 𝗮𝗹𝗴𝗼𝗿𝗶𝘁𝗵𝗺 that accurately determines true molecular position, even at the 𝗥𝗮𝘆𝗹𝗲𝗶𝗴𝗵 𝗹𝗶𝗺𝗶𝘁, and 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝘀 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗯𝘆 ~𝟳𝟬%. Huge congratulations to all authors! www.nature.com/articles/s41...

Molecular mapping in DNA-PAINT via modified Gaussian Mixture Modeling - Nature Communications

Standard algorithms fail to fully exploit the spatial information in DNA-PAINT. Here, the authors present G5M, an algorithm providing molecular maps by accurately inferring biomolecule positions at di...

nature.com

🔬𝗖𝘂𝗿𝗶𝗼𝘂𝘀 𝗮𝗯𝗼𝘂𝘁 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗯𝘂𝘁 𝗱𝗼𝗻’𝘁 𝘄𝗮𝗻𝘁 𝘁𝗼 𝗽𝗿𝗲𝗽 𝗮 𝘀𝗮𝗺𝗽𝗹𝗲? Need a 𝗿𝗲𝗹𝗶𝗮𝗯𝗹𝗲 #𝗦𝗠𝗟𝗠 𝗱𝗲𝗺𝗼 𝘀𝗹𝗶𝗱𝗲 for your next workshop? Meet our 𝗦𝘁𝗮𝗯𝗹𝗲 𝗖𝗲𝗹𝗹 𝗦𝗹𝗶𝗱𝗲!A ready-to-image sample with 𝗱𝘂𝗮𝗹-𝘁𝗮𝗿𝗴𝗲𝘁 𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝗼𝗳 𝗺𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 𝗮𝗻𝗱 𝘃𝗶𝗺𝗲𝗻𝘁𝗶𝗻.Load and image - no prep required. www.massive-photonics.com/product-cate...

🚀 𝗔𝗹𝗿𝗲𝗮𝗱𝘆 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 (𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁) 𝗽𝗿𝗼𝘁𝗲𝗶𝗻-𝘁𝗮𝗴𝘀? Take your imaging to the nanoscale with our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀. 🔬 Available for: · GFP · Halo · RFP · ALFA · TagFP · mEOS 𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗸𝗶𝘁𝘀: www.massive-photonics.com/product-cate... #DNAPAINT #SMLM

🚨New publication alert🚨 Authors introduce Dynamic Binder Exchange (DyBE), an approach that improves labeling efficiency in DNA-PAINT up to 15-fold. onlinelibrary.wiley.com/doi/10.1002/... Congratulations to all authors!!

Dynamic Binder Exchange Improves Protein Labeling Efficiency in DNA‐PAINT up to 15‐Fold

Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15-fold in super-resolution microscopy. DyBE maps nanoscale receptor tyrosine kin...

onlinelibrary.wiley.com

🎉 𝗡𝗲𝘄 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗮𝗹𝗲𝗿𝘁 🎉 Authors used 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 & 𝗣𝗲𝗽𝘁𝗶𝗱𝗲-𝗣𝗔𝗜𝗡𝗧 to investigate the 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗘-𝗰𝗮𝗱𝗵𝗲𝗿𝗶𝗻 𝗮𝗻𝗱 𝗙-𝗮𝗰𝘁𝗶𝗻 at adherens junctions in 𝗗𝗿𝗼𝘀𝗼𝗽𝗵𝗶𝗹𝗮 𝗲𝗺𝗯𝗿𝘆𝗼𝗻𝗶𝗰 𝘁𝗶𝘀𝘀𝘂𝗲. Congrats to all authors! Our anti-GFP kit was used for E-cadherin imaging. 🔗 www.cell.com/biophysj/ful...

DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue

Cell junction remodeling is central to epithelial morphogenesis and tissue rheology, and depends on the interplay between adhesion molecules and the actomyosin cortex. E-cadherin constitutes the molec...

cell.com

The coolest Christmas party ever? 🏎️🎄We think so. We swapped lab coats for helmets and raced around the track...turns out our need for speed doesn't stop with experiments. 🥇Jürgen, CEO 🥈Lucia, Scientist 🥉Jonas, Scientist

New preprint alert! www.biorxiv.org/content/10.6... Authors developed DNA-fluorophore labels inspired by DNA-PAINT & enhanced with LNA, enabling robust signal amplification for quantitative STED imaging with single-protein resolution. Congrats to all authors! Our reagents were used for EGFR imaging.

Quantitative STED microscopy with DNA-fluorophore labels

Stimulated emission depletion (STED) microscopy enables super-resolution imaging of complex biological samples in 3D, in large volumes, and live. However, molecular quantification with STED has remain...

biorxiv.org

Who knew Christmas could be so pink? 💗🎄 Team outing to Munich's famous Pink Christmas Market = pink lights, fun vibes, and great company.

𝗧𝗮𝘂 𝗻𝗮𝗻𝗼-𝗮𝗴𝗴𝗿𝗲𝗴𝗮𝘁𝗲 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 𝗿𝗲𝘃𝗲𝗮𝗹𝗲𝗱 𝗯𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 Full study: doi.org/10.1002/advs... Authors used our anti-mouse and anti-rabbit DNA-PAINT kits for tau visualization in brain tissue sections. Congratulations to all authors!! #DNAPAINT #SMLM #MassivePhotonics

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease

Super-resolution microscopy identifies nano-sized tau aggregates (nano-aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age-Relate...

doi.org

🚀 𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗠𝗔𝗦𝗦𝗜𝗩𝗘-𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗣𝗿𝗼𝗯𝗲𝘀 𝗮𝗻𝗱 𝗕𝘂𝗳𝗳𝗲𝗿 𝗞𝗶𝘁𝘀 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 of RNA targets 𝘂𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆. 🔗: www.massive-photonics.com/product-cate... #SMLM #DNAPAINT #RNAImaging #RNAFISH #Microscopy #MassivePhotonics

New pre-print alert! “𝟯𝗗 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗰𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝘄𝗶𝘁𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗿𝗲𝘀𝗼𝗹𝘃𝗲𝘀 𝘁𝗵𝗲 𝗮𝗿𝗿𝗮𝗻𝗴𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗕𝗮𝘀𝘀𝗼𝗼𝗻 𝗮𝘁 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲𝘀” Congrats to all authors!! www.biorxiv.org/content/10.1... #MINFLUX #DNAPAINT #MassivePhotonics #Microscopy #Bassoon

3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones

Neurotransmitter release and membrane retrieval at active zones require precise spatial and temporal coordination relying on an intricate molecular machinery. However, the exact nano-structural organi...

biorxiv.org

Join us & Massive Photonics on 23 Oct 2025 (4–5 PM CET) for a webinar with Prof. Ralf Jungmann, KOL on DNA-PAINT! Discover how single-molecule #SpatialOmics is reshaping #BioImaging. 🎁 Win a Smart DNA-PAINT Kit! Register now: us06web.zoom.us/webinar/regi... #DNAPAINT #Microscopy #SMLM

Don’t forget to come by our booth at #SeeingIsBelieving2025!! We can't wait to chat 🧬 🔬 📍Booth No. 6 #DNAPAINT #SMLM #Superresolution #Microscopy

🧬 𝗡𝗲𝘄 𝗣𝗿𝗼𝗱𝘂𝗰𝘁 𝗟𝗮𝘂𝗻𝗰𝗵! 🧬The highly-requested 𝗮𝗻𝘁𝗶-𝗛𝗮𝗹𝗼 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁 is finally here! Reveal nanoscale organization of Halo-tagged proteins with our plug-and-play DNA-PAINT kit. 🔗Learn More: www.massive-photonics.com/product-cate...

🔬 𝗪𝗵𝗶𝗰𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲 𝗶𝘀 𝗿𝗶𝗴𝗵𝘁 𝗳𝗼𝗿 𝘆𝗼𝘂? Our #DNAPAINT Labeling Kits let you choose the balance of 𝘀𝗽𝗲𝗲𝗱 𝗮𝗻𝗱 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 that fits your research. ⭐DNA-PAINT kits: www.massive-photonics.com/product-cate... ⭐FAST DNA-PAINT kits: www.massive-photonics.com/product-cate...

🚀 New Product Launch! 🚀 Ready to push your imaging to 𝘀𝘂𝗯-𝗻𝗮𝗻𝗼𝗺𝗲𝘁𝗲𝗿 𝘀𝗽𝗮𝘁𝗶𝗮𝗹 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻? Introducing our newest 𝗥𝗘𝗦𝗜 𝗞𝗶𝘁 𝗳𝗼𝗿 𝗔𝗟𝗙𝗔-𝘁𝗮𝗴𝗴𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻𝘀! 🔗 www.massive-photonics.com/product-cate... #SMLM #RESI #DNAPAINT #Microscopy #nuclearpore

🚀 New to DNA-PAINT? We make getting started simple. Check out our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 #DNAPAINT 𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗸𝗶𝘁𝘀: ✅ Seamless integration into immunostaining workflows ✅ Wide range of kits designed for various targets ✅ Includes all labeling & imaging reagents needed 🔗 massive-photonics.com

📢 Don’t forget to stop by our booth at #SMLMS2025! We’re excited to share how our #DNAPAINT solutions and labeling kits can help you unlock nanoscale insights 🔬🧬 📍WP Building Foyer, near the windows