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Matilde Florean

@matildeflorean.bsky.social

🌱 enzymes and pseudoenzymes, evolution of natural products. PhD student at MPI for chemical ecology.

3 Posts39 Follower83 Folgt
Carsten Schotte@carstenschotte.bsky.social · 2y ago

All good things must come to an end... and apparently, all BAHD ones too! 😅 Check out our latest preprint on bioRxiv: www.biorxiv.org/content/10.1... Thanks to the great team at @oconnorlab.bsky.social, @mpi-ce.bsky.social, and our collaborators at Uni York — couldn't have done it without you all!

BAHD news from Euphorbia peplus: identification of acyltransferase enzymes involved in ingenane diterpenoid biosynthesis

The plant family Euphorbiaceae are an abundant source of structurally complex diterpenoids, many of which have reported anti-cancer, anti-HIV, and anti-inflammatory activities. Among these, ingenol-3-...

biorxiv.org

Dan Udwary@danudwary.secondarymetabolism.com · 2y ago

Very pleased to announce that our manuscript describing @jgi.doe.gov 's Secondary Metabolism Collaboratory is now available! SMC has been up and active for a while now, but I'm really excited to start seeing more activity on here. Lots more to come. doi.org/10.1093/nar/...

The secondary metabolism collaboratory: a database and web discussion portal for secondary metabolite biosynthetic gene clusters

Abstract. Secondary metabolites are small molecules produced by all corners of life, often with specialized bioactive functions with clinical and environme

doi.org

Conor McClune@cmcclune.bsky.social · 2y ago

Our Taxol pathway preprint! We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor. Biggest surprise: a new protein that helps our oxidases produce the correct product

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors

Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...

biorxiv.org

Matilde Florean@matildeflorean.bsky.social · 2y ago

The working dead 🧟‍♀️: not just a metaphor for PhD students but also an enzymatic strategy! If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1... #PlantBiology#natprod @oconnorlab.bsky.social

Highjacked by a pseudoenzyme: How eudicot plants make indole

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org