ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis - Nature Communications

In this work, the authors reveal that three non-ribosomal peptides targeting a common protein quality system differentially alter the Mycobacterium tuberculosis proteome, providing new insight into th...

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Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis - Nature Communications

Mycobacterium tuberculosis owes its success partly to its ability to enter a ‘dormant’, non-replicative state, reactivating years or even decades after initial infection. In this work, authors find th...

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Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis - Nature Communications

The MmpL5/MmpS5 efflux system is crucial for drug extrusion and siderophore export in M. tuberculosis. Here, the authors report its high-resolution cryo-EM structures, revealing a unique trimeric asse...

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Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity | PNAS

Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the em...

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Bifidobacteria support optimal infant vaccine responses - Nature

Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

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