Next week!! The JACS Symposium: CSJ Spring Meeting is an inspiring full-day, in-person symposium spotlighting cutting-edge research in organic, inorganic, polymer, and materials chemistry. pubs.acs.org/JACS-Symposi...

Join leading chemists, a Nobel Laureate, researchers, and journal editors in Jeju Island, Republic of Korea, as we celebrate 150 years of ACS, chemical discovery, and explore the future of scientific collaboration pubs.acs.org/JACS-Symposi...

Congratulations to #OrgLett Executive Editor Margaret Brimble on being named Honorary Fellow of the RSC! We are honored to have you and several other 2026 Honorary Fellows on our teams at ACS www.rsc.org/news/2026-ho...

ACS Industry Insider and OPR&D have teamed up to bring some Lessons Learned in Organic Process Chemistry to the forefront of discussion. Our webinar with Yuhei Yamamoto showcased how even elevation of a CDMO can affect route optimization! axial.acs.org/chemical-eng...

Hard-Won Lessons from Industrial Chemistry Failures | ACS Publications Chemistry Blog

A collection of candid case studies reveals how industrial chemists diagnose failures and redesign processes with clarity and purpose.

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Truly never out of style! #JOrgChem celebrates the latest physical organic chemistry research with nearly 100 articles in this Special Issue. From quantum tunneling to catalyst design revealing how structure, energy, and environment drive reactivity! pubs.acs.org/page/joceah/...

🚨 Call for Short Papers – Communications & Technical Notes Have a breakthrough that doesn’t fit a full-length article? #OPRD is now accepting Communications and Technical Notes—short, focused papers designed to move ideas forward faster. 👉 axial.acs.org/organic-chem...

Call For Papers: Communications & Technical Notes in OPR&D | ACS Publications Chemistry Blog

Have a short story to share, or a new protocol that doesn’t fit into a standard full Article? OPR&D is putting out this open Call for Short Papers, welcoming submissions as Communications or Technical...

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Submit your Lunar New Year themed covers celebrating the Year of the Horse! 🎆 Submissions in process until February 10 will be considered. Only a few will publish on the front cover an an issue of #OrgLett! Check out last year's covers featured here ➡️ axial.acs.org/organic-chem...

Highlighting Chinese Chemists in Organic Letters: Chinese New Year Cover Series, 2025 China Collection, and All-Star Academy Webinar | ACS Publications Chemistry Blog

Join ACS Publications in celebrating China’s leading researchers, cultural heritage, and impactful work published in the journal.

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This special collection showcases impactful work supported by the ACS Petroleum Research Fund (PRF) over the past 25 years, highlighting advances in catalysis, energy, and sustainability that span inorganic, organic, and organometallic chemistry. pubs.acs.org/page/vi/cele...

Sign up for our ACS Publications Industry Webinar where we will have #OPRD author Yuhei Yamamoto describe a real-world case study on scale-up of Suzuki-Miyaura couplings. December 11, 2025 at 9 AM Japan Standard Time (December 10, 2025 at 7 PM ET / 4 PM PT) access.acspubs.org/SuzukiMiyaur...

Safety First in Organic Chemistry! ⚠️ #OrgLett published its first "Safety Letter" by Garg, Zhao, and co-workers, spotlighting IBX—a widely used oxidant with explosive potential. Read the Safety Letter and Editorial in this week's issue: pubs.acs.org/toc/orlef7/2...

Submit your nominations today for the Organic and Inorganic Lectureship Awards! Winners will receive an honorarium, plaque, and travel to ACS Fall 2026 in Chicago, IL, to present their outstanding work. axial.acs.org/organic-chem...

Organic and Inorganic Chemistry Lectureships and Awards | ACS Publications Chemistry Blog

Explore both current and past journal lectureships and awards from ACS Publications' Organic and Inorganic portfolio.

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Time is running out! ⏲️ Submit your manuscript by Dec 31 to #JOrgChem or #Biochemistry for this joint Special Issue featuring the chemistry and biology of peptides. Learn more and submit here 👉 axial.acs.org/biology-and-...

Call For Papers: Chemistry and Biology of Peptides | ACS Publications Chemistry Blog

This Special Issue will celebrate the chemistry and biology of peptides, from synthesis, to structure and modifications, to biology and applications, and finally to degradation. Submit your manuscript...

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Unlocking the secrets of GH161 enzymes! 🧬 Using cryo-EM, Moulis, Cioci, & co-workers reveal how β-glucan phosphorylases reshape during catalysis—shedding light on the molecular choreography of GH-Q clan enzymes #Biocatalysis #ACSCatalysis @cathleencrudden.bsky.social pubs.acs.org/doi/10.1021/...

Structural and Functional Dissection of GH161 β-Glucan Phosphorylases: Molecular Specificities and Dynamics of Catalysis of Dimeric GH-Q Enzymes

In the CAZy classification of carbohydrate-active enzymes, the GH-Q clan regroups three distantly related glycoside hydrolase (GH) families: GH94, GH149, and GH161. These families contain glycoside ph...

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The ACS GCI PR Industry Awards spotlight the best in sustainable/green chemistry innovation across the pharma industry and allied industrial partners. Submit your nomination by Dec. 8! ➡️ acsgcipr.org/funding-awar...

Copper–Iron catalysis unlocks efficient cross-coupling of sterically hindered sulfonamides with (hetero)aryl chlorides & alkyl halides in #OrgLett #EditorsChoice ✅ Diverse substrate scope ✅ Gram-scale ✅ 10 sulfonamide drugs synthesized Read more 👉 pubs.acs.org/doi/10.1021/...

Copper–Iron-Catalyzed Cross-Coupling of ortho-Substituted Sulfonamides with Sterically Hindered (Hetero)aryl Chlorides and Alkyl Halides: Synthesis of Sulfonamide Drugs

We describe for the first time an effective copper–iron-catalyzed cross-coupling strategy that enables the reaction for a diverse array of ortho-substituted primary (hetero)aryl and aliphatic sulfonam...

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🚨 Call for Papers! Ready to reshape the future of organic synthesis? Submit to our Special Issue: “Skeletal Editing, Molecular Metamorphosis & Structural Reprogramming” jointly hosted by #OrgLett & #JOrgChem 📅 Deadline: June 1, 2026 axial.acs.org/organic-chem...

In situ TEM doesn't get the full picture. Atomic-resolution imaging is powerful, but sub-nanosecond catalyst dynamics remains difficult. This #EditorsChoice #ACSCatalysis Viewpoint shows why we need more than TEM by Tibor Szilvási pubs.acs.org/doi/10.1021/...

Temporal Resolution of In Situ TEM Limits the Characterization of Catalyst Site Dynamics

In situ transmission electron microscopy (TEM) provides a means for capturing atomic-resolution micrographs under reactive environments and has been widely employed to identify active site candidates ...

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Nominate work for the #JOrgChem 2026 Outstanding Paper of the Year Award by Dec 31! The award winner will receive: - $2000 USD prize - Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture - Award plaque americanchemical.co1.qualtrics.com/jfe/form/SV_...

Sign up for our ACS Publications Industry Webinar where we will have Amanda Stahl (Amgen) describe the fascinating process development of a key Sotorasib intermediate. Nov 11, 2025 at 12:00 noon (EST) access.acspubs.org/Rac4Process

Check out this CF2 synthon enabled by dual Rh-Zn catalysis in #ACSCatalysis #EditorsChoice pubs.acs.org/doi/10.1021/...

Asymmetric Diamination of the In Situ Generated Difluoroenol Species Using Azocarboxamides as an N Source

The Rh2(esp)2 and Zn(II)-bisoxazoline (BOX) complex-cocatalyzed asymmetric diamination of in situ generated difluoroenol species with azocarboxamides has been disclosed. This reaction features a formal [3 + 2]-cycloaddition reaction using difluoroenol intermediate as a C2 synthon, providing an efficient and robust approach for the synthesis of difluorinated imidazolidin-2-ones in good yields with high to excellent stereoselectivity (up to 95% ee). This method offers a complementary approach for the direct assembly of chiral difluoromethylene incorporated heterocycles by introducing in situ formed difluoroenol species as a practical C2 synthon rather than using presynthesized gem-difluoroalkenes. With this protocol, further synthetic applications in fluorine chemistry could be envisioned through the strategic interception of difluoroenol via cycloaddition reactions with appropriate partners.

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Submit your nominations for the ACS Catalysis Lectureship Award by Dec 31! The award winner will receive: - $1000 USD prize - Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture - Award plaque americanchemical.co1.qualtrics.com/jfe/form/SV_...

Nominate Articles for the #OPRD 2026 Outstanding Paper of the Year Award by Dec 31! The award winner will receive: - $2000 USD prize - Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture - Award plaque americanchemical.co1.qualtrics.com/jfe/form/SV_...

Nominate Letters for the #OrgLett 2026 Outstanding Paper of the Year Award by Dec 31! The award winner will receive: - $2000 USD prize - Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture - Award plaque americanchemical.co1.qualtrics.com/jfe/form/SV_...

🚨Special Issue Alert🚨 π-Conjugated Molecules & Materials in #OrgLett Honoring August Kekulé and Eric Clar, this Special Issue showcases everything from CPL and optoelectronics, to nonbenzenoid aromatic compounds and nanohoops. pubs.acs.org/page/orlef7/...

Upcoming: ACS150 JACS Symposium: Expanding Horizons of Nanoscience & Energy Celebrating 150 years of ACS and chemical discovery with two days of cutting-edge science in nanoscience and energy. 📍 @ethz.ch, Switzerland 📅 12-13 January 2026 Apply to attend: buff.ly/wwbZ5c6

Another #EditorsChoice article published in #JOrgChem! Learn more about cyclopropane annulation to form elusive iminodihydrothiophene derivatives from Maity and co-workers pubs.acs.org/doi/10.1021/...

[3 + 2] Annulation of Donor–Acceptor Cyclopropanes with Ammonium Thiocyanate: Interrupted Cascade Leads to Elusive Iminodihydrothiophene Derivatives

A zinc iodide-mediated [3 + 2] cyclization between donor–acceptor cyclopropanes and ammonium thiocyanate has been developed to afford 2-imino-tetrahydrothiophene derivatives under mild conditions. Sub...

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Editors' Choice alert! Plunkett, et al. in #OrgLett: A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides pubs.acs.org/doi/10.1021/...

A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides

Advancements in the field of C(sp2)–C(sp3) cross-coupling using alcohols as feedstocks have resulted in widespread adoption in analogue synthesis. Using high-throughput experimentation, an in situ alc...

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Congrats and thanks to Neil Garg, Ralph Zhao, and co-workers for publishing #OrgLett 's first Safety Letter: Evaluation of the Popular Oxidant 2-Iodobenzoic Acid (IBX) pubs.acs.org/doi/10.1021/...

Conducting impactful research for the betterment of the world and our society ought not to be overshadowed by the dangers and risks its practitioners take on. -- Read about our Safety Letter initiative at #OrgLett pubs.acs.org/doi/10.1021/...

Emphasizing Safety in Publications at Organic Letters: The Safety Letter

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"Failure is the mother of success" -- Read case studies highlighting the knowledge gained from failures and unexpected results in this Lessons Learned in Organic Process Chemistry Special Issue in #OPRD @pubs.acs.org pubs.acs.org/page/oprdfk/...