Survey for the MBSJ Career Development Committee's Lunchtime Seminar 2026

At the 49th MBSJ Annual Meeting (held as BMB2026), we will host two lunchtime seminars entitled "Is 'Just Put Up with Being Poor' Outdated? Young Researchers and Financial Issues" and "How Can We Buil...

docs.google.com

<fc>RNA</fc>‐Seq Profiling Reveals Transcriptional Changes in Phosphorylation‐Site Mutants of Brg1

Expression of RNA polymerase II–dependent genes was significantly reduced in JHOC5 and BRG1-S1452A cells, suggesting a role for BRG1 phosphorylation in RNA polymerase II–dependent gene expression. In...

doi.org

The Nuclear Export Signal of <fc>IκBα</fc> Drives <fc>RelB</fc> Oscillations in the Noncanonical <fc>NF</fc>‐<fc>κB</fc> Pathway

The IκBα nuclear export signal drives oscillatory dynamics of RelB in the noncanonical NF-κB pathway. Following LTβR stimulation, p100 processing releases RelB for nuclear import, while IκBα-mediated...

doi.org

Partial Depletion of <fc>SART1</fc> Selectively Induces Mitotic Defects and Cell Death in Cancer Cells

Partial depletion of SART1 selectively induces spindle defects and cell death in cancer cells while sparing normal cells. c-Myc–mediated transformation confers sensitivity to SART1 depletion, providi...

doi.org

A Persistent Homology Approach Enables Single‐Cell Detection of Chromatin Spatial Organization Changes During Pathological Senescence Transition

Persistent homology quantifies chromatin dynamics from single-cell fluorescence images. Coupled with unsupervised machine learning, this approach reveals cellular trajectories and provides insight in....

doi.org

Interaction Between <fc>Rec</fc>8 and <fc>Mis</fc>4 Is Required for Axis‐Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis

We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4-LR mutant...

doi.org

Survey for the MBSJ Career Development Committee's Lunchtime Seminar 2026

At the 49th MBSJ Annual Meeting (held as BMB2026), we will host two lunchtime seminars entitled "Is 'Just Put Up with Being Poor' Outdated? Young Researchers and Financial Issues" and "How Can We Buil...

docs.google.com

Novel Ligands for the Orphan Receptor GPR151 Modulate Morphine Action

The new GPR151 ligands altered the analgesic effects of morphine.

doi.org

POU5F1/OCT4 Attenuates Human LINE‐1 Expression Levels in Induced Pluripotent Stem Cells

LINE-1 elements are actively transcribed in human pluripotent stem cells. Pluripotency-associated transcription factors bind to young LINE-1 loci to attenuate their transcription. Loss of these facto...

doi.org

Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts

Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins a...

doi.org

A GPI‐Anchored Ly6/uPAR Superfamily Gene belly roll Is Expressed in Multiple Peptidergic Neurons in Drosophila melanogaster Larvae

The expression pattern of bero in the Drosophila larval central nervous system was analyzed using a combination of the T2A GAL4 system and scRNA-seq analysis. bero was expressed in several peptidergi...

doi.org

Pharmacological Correction of Aberrant DSCAML1 Localization by 4‐Phenylbutyrate Ameliorates Epileptic Phenotypes in a Mouse Model Harboring the Patient‐Specific A2105T Mutation

The epilepsy-associated DSCAML1 A2105T mutation causes intracellular protein accumulation and loss of surface expression. We demonstrate that the chemical chaperone 4PBA restores surface localization...

doi.org

Mislocalized Cytosolic Polyphosphate Forms Potentially Toxic Droplets, Highlighting the Essentiality of Vacuolar Polyphosphate in Pi Homeostasis

Polyphosphate (polyP) is a universal and multifunctional biopolymer whose essential roles remain elusive. In fission yeast, endogenous vacuolar polyP supports cellular survival by maintaining phospha...

doi.org

Historical Dynamics of Transposable Elements in Herbarium Specimens of Arabidopsis thaliana Collected in Germany

This study analyzes transposable element dynamics in Arabidopsis thaliana herbarium specimens collected in Germany (1817–1957) using whole-genome sequencing and the TEF program. We identified 331 TE ...

doi.org