🧬The power of dual-promoters: Dual-promoter control of gene expression: from transcriptional fine-tuning to antibiotic resistence. ➡️ A review in Current Opinion in Microbiology by P. Sudzinová, T. Knežová Balgová, Š. Bobková, M. Schwarz, L. Krásný. www.sciencedirect.com/science/arti...

Dual-promoter control of gene expression: from transcriptional fine-tuning to antibiotic resistance

The first and arguably most critical level of gene expression is transcription of the genetic information from DNA into RNA. Within this process, tran…

sciencedirect.com

🧬Start–stop “gates” regulate protein production in human cells 📄Justin Rendleman et al., Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons. Nucleic Acids Research Co-led by Leoš S. Valášek, IMIC CAS academic.oup.com/nar/article/...

Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons

Abstract. Start–stop elements are translation regulatory elements in 5′ untranslated regions (UTR) of eukaryotic transcripts, consisting of a start codon i

academic.oup.com

📰 Časopis A / Easy vydává Akademie věd ČR. 📬 Chcete každé jeho vydání dostat přímo do schránky? 📧 Napište si o předplatné tištěného magazínu zdarma na adresu predplatne@ssc.cas.cz.

🎉 Congratulations to Dr. Martin Schwarzer on his formal appointment as the Head of the Laboratory of Gnotobiology! We are confident that under his leadership, the laboratory will continue to thrive, drive innovation, and reach new heights in scientific excellence. @mbuavcr.bsky.social

🔬 Science creates impact when it reaches society! At the cinema in our village, Nový Hrádek, we ran a community outreach program on Gnotobiology. 🦠 Thanks to Nový Hrádek municipality and INTER-MICRO OP JAK project for supporting this initiative! 🌍 @mbuavcr.bsky.social @schwarzergnoto.bsky.social

🔬 We’re Hiring: Two Postdoctoral Fellows at the Laboratory of Gnotobiology at the IMIC CAS, Czech Republic, to join our team through the Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowships 2026 program. @mbuavcr.bsky.social 🔗 mbu.cas.cz/kariera/voln... 🔗 mbu.cas.cz/kariera/voln...

Congratulations to our outstanding scientist Dr. Barbora Valášková for delivering an engaging lecture on how the microbiome influences our brain during Brain Awareness Week at the Městská knihovna Nové Město nad Metují. @valaskova.bsky.social @mbuavcr.bsky.social www.knihovnanm.cz/cs/ovlivnuje...

How Bordetella resist removal by the mucociliary “escalator” that normally clears the respiratory tract of microbes? #paper in Science (2026). Costello et al.📄 Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization🦠 www.science.org/doi/10.1126/...

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization

Pathogenic Bordetella bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of Bordetell...

science.org

🔓Check out this #OpenAccess review in our latest issue by Vladimír Křen & co. @vschtpraha.bsky.social & @mbuavcr.bsky.social summarising the formation and occurrence of glycosylated mycotoxins and their transformations in the food chain #natprod Read it in full here👇

Glycosylated mycotoxins: a hidden enemy

Covering: 2010 up to 2025 (May) Mycotoxins, secondary metabolites produced by filamentous fungi, are highly toxic contaminants of food crops. These contaminated plants pose a significant health risk…

pubs.rsc.org

🧠Týden mozku 2026 vám od 9. do 15. března otevře dveře do světa myšlení, paměti i emocí. 📍V Praze na Akademii věd ČR i v dalších městech Česka chystáme přednášky a workshopy pro všechny, kdo chtějí pochopit, jak tento „vnitřní kosmos“ funguje.

@czechacademy.bsky.social 🔬The cryo-EM structure of Photosystem I from Chromera velia with a bound superoxide dismutase heterodimer. Yuan, X., Lukeš, M., Qian, P. et al. Nat Commun (2026) doi.org/10.1038/s414...

The cryo-EM structure of Photosystem I from Chromera velia with a bound superoxide dismutase heterodimer - Nature Communications

The alveolate alga Chromera velia is a close relative of parasitic apicomplexans that possesses an unusual Photosystem I. Here, the authors present the cryo-EM structure of this complex, revealing sev...

doi.org

How can we communicate science in a society that is growing more polarized? Tackling hate speech, anti-elitism, anti-rationalism, mistrust in scientists & populism were all discussed at SciComm 360° ➡️ www.avcr.cz/en/news-arch... @maxplanck.de @tomaskoblizek.bsky.social @flu-cas.bsky.social

❄Cílem projektu je zhodnotit kontaminace věčnými chemikáliemi z lyžařských vosků v modelovém území chráněné oblasti CHKO Jizerské Hory. Závodníci fluorové vosky už používat nesmí. Pro rekreační lyžaře zatím podobný zákaz neplatí. Jak vypadají průběžné výsledky👇 www.irozhlas.cz/zpravy-domov...

Vyšší koncentrace než v čističce. Vědci z Akademie věd zkoumají zamoření jizerských stop fluorovými vosky

Nemažte lyže vosky s fluorem, škodí zdraví i horám - apelují na lyžaře mikrobiologové. Profesionální lyžaři fluorové vosky už používat nesmějí. Rekreační lyžaři je ale do stop stále zanáší.

irozhlas.cz

📄Publication Colorimetric determination of the plant toxin β-cyano-l-alanine using a multistep enzyme reaction. Talanta (2026); L. Martínková, R. Příhodová, L. Rucká, M. Kotik, B. Křístková, V. Křen, P. Bojarová www.sciencedirect.com/science/arti... Laboratory of Biotransformation

Colorimetric determination of the plant toxin β-cyano-l-alanine using a multistep enzyme reaction

The non-proteinogenic amino acid β-cyano-l-alanine (AlaCN) is a plant toxin formed during HCN detoxification. The presence of AlaCN and its dipeptide,…

sciencedirect.com

Proč dal mikrobiolog Rufin Kouipou přednost Česku před Japonskem? V rámci MERIT hledá v @mbuavcr.bsky.social nová antibiotika. 🦠 Rufin vysvětluje, proč je pro vědce stabilita důležitější než prestižní, ale krátká stipendia. Oceňuje českou otevřenost i přímočarost. 👉 bit.ly/4qFHixF

A new paper🧬Bacteria sense the antibiotic rifampicin through a widespread dual-promoter based alarm system Nucleic Acids Research (2026) Lab of Microbial Genetics and Gene Expression IMIC, @iocbprague.bsky.social @ibtcas.bsky.social @akademievedcr.bsky.social ➡️ academic.oup.com/nar/article/...

Bakterie v našich střevech ovlivňují naši náladu, imunitu, rychlost stárnutí i to, jestli máme chuť na 🍫 nebo 🥕🥦. Jak „druhý mozek“ funguje a co mu prospívá, zkoumá Martin Schwarzer @schwarzergnoto.bsky.social z MBÚ @akademievedcr.bsky.social @gnotobiology.bsky.social ➡️ forbes.cz/mikrobiom-ri...

Mikrobiom řídí vše. Co udělat, aby lépe fungoval? Strčte ruce do hlíny, říká vědec

Říká se mu druhý mozek. Mikrobiom ovlivňuje v našem těle všechno. Co mu prospívá a jak souvisí i s dlouhověkostí, vysvětluje v rozhovoru laureát Ceny Neuron Martin Schwarzer.

forbes.cz

Scientists from CEITEC @masarykuniversity.bsky.social contributed to @sciencecharles.bsky.social and @mbuavcr.bsky.social research revealing how resilient mycobacteria are able to adapt to different temperature conditions 🦠 Read more ➡️ www.ceitec.eu/how-do-bacte...

📄Producing Trojans: hijacking of monocyte differentiation by pathogens Trends in Microbiology (2025)🦠 review by Jawid Nazir Ahmad & Peter Šebo Laboratory of Molecular Biology of Bacterial Pathogens, IMIC www.cell.com/trends/micro...

Producing Trojans: hijacking of monocyte differentiation by pathogens

Pathogens can exploit the plasticity of host immune cells, such as the pathway of monocyte differentiation into macrophages and dendritic cells. This review discusses how microbial pathogens hijack th...

cell.com

new year, new seminar series 😉 See you on Fridays at FGÚ (IPHYS) lecture hall.

„‚K lesu zády, k Ivanovi čelem” ❄️ Michal si vezme na pomoc model a spočítá, jestli by kyj loupežníků dokázal změnit děj jedné zimní pohádky.“ 👇

Happy holidays ✨🎄🎁 and a wonderful New Year! ❤️

🧠 Can the gut affect how well multiple sclerosis treatment works? New Czech research says yes. 📄 Ocrelizumab transiently alters microbiota and modulates immune response depending on treatment outcome; Coufal, S. et al. iScience (2025) www.sciencedirect.com/science/arti...

📄🦠 Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium M. Pospíšilová, A. Dreus, P. Matheova, J. Schmidtova, B. Pravdova, M. Blazikova, M. Capek, O. Cerny Laboratory of Bacterial Virulence PLOS: dx.plos.org/10.1371/jour...

Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium

Author summary Systemic infection and survival of Salmonella within host cells depend on expression of effector proteins that manipulate host cell functions. Here, we show that expression of these eff...

dx.plos.org

👏We would like to congratulate our researchers who have been awarded new GAČR projects as principal investigators as well as co-investigators! In addition to providing substantial financial support for research, obtaining GAČR funding is a measure of high-quality scientific work.

🎉 Congratulations to our 2025 Czech Science Foundation awardees from Lab of Gnotobiology: Drs Marek Šinkora, Martin Schwarzer, Dagmar Šrůtková and Sudhanshu Shekhar 👏 A special shout-out to Dr Martin Schwarzer’s group for securing three grants this year @mbuavcr.bsky.social gacr.cz/en/next-year...

Open Science high school internships in English offered at our @fzuavcr.bsky.social, @mbuavcr.bsky.social, @utia.cas.cz, @iocbprague.bsky.social, @ibtcas.bsky.social, @flu-cas.bsky.social, Institute of Atmospheric Physics, & Institute of Inorganic Chemistry. Register by 30 Nov! www.otevrenaveda.cz

The fungal skin pathogen apparently helps itself by producing toxin-like substances that facilitate infection of new hosts. These substances can suppress the immune response and thus accelerate the spread of the pathogen among humans. Study ➡️ journals.asm.org/doi/10.1128/... @mbuavcr.bsky.social

Comparative gene expression analysis in closely related dermatophytes reveals secondary metabolism as a candidate driver of virulence | Microbiology Spectrum

Trichophyton benhamiae var. luteum is an emerging fungal pathogen responsible for a rising number of skin infections transmitted from guinea pigs to humans, especially in Europe. We investigated why t...

journals.asm.org

Today is the International Day Against Violence and Bullying at School. An ERC-funded research has revealed that bullying triggers the same stress responses in the brain as physical threats. Let’s continue raising awareness, offering support, and speaking up. 👉

Koulukiusaamisen jäljet näkyvät aivoissa vielä aikuisenakin | Verkkouutiset

Koulukiusaamisen jäljet näkyvät aivoissa vielä aikuisenakin | Verkkouutiset

buff.ly

📄Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation. Nat Commun 16, 9664 (2025). doi.org/10.1038/s414... International team driven by Jiri Neuzil @ibtcas.bsky.social 🐁📊 #MassSpectrometryImaging Laboratory of Molecular Structure Characterization, IMIC

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation - Nature Communications

The authors show that regenerating liver requires de novo pyrimidine synthesis and it uses ammonia as precursors differentially as it traverses the liver zones. Tracing studies and spatial metabolomic...

doi.org