New paper led by postdoc @yannikipouros.bsky.social is out today in Nature! We show how metal coordination mining of AlphaFold reveals dozens of new radical halogenase families, including the promiscuous biocatalyst BtnX. #enzymes #bioinformatics #biocatalysis #secmet www.nature.com/articles/s41...

Targeted enzyme discovery using metal-coordination mining - Nature

A methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery of new families of radical halogen...

nature.com

We are very excited that Michelle Chang (@mchanggroup.bsky.social) and Giulio Superti-Furga (@supertifurgalab.bsky.social) will be our keynote speakers at this year's event on September 29th, 2026. If you do not want to miss anything, sign up for our mailing list: fd24.formdesk.com/universiteit...

Congratulations to former student Eli and the team on their new paper in Nature Chemical Biology! Here they show that the difference in radical rebound of FeII/aKG halogenases is uniquely controlled by the switching of the metal ligand bond axes! Take a look: www.nature.com/articles/s41...

Dynamic metal coordination controls chemoselectivity in a radical halogenase - Nature Chemical Biology

Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.

nature.com

Congrats to lead author Doug and team on their new preprint, which describes a genome mining strategy to find non-canonical amino acid-based secondary metabolites outside of RiPP and NRPS pathways! Read more below: chemrxiv.org/engage/chemr...

tRNA-Deacylase Directed Discovery of Biosynthetic Pathways

Amino acids are one of nature’s most privileged building blocks for generating molecular diversity on length-scales ranging from small molecules to proteins. While amino acid products arising from cer...

chemrxiv.org