Fundación MEDINA

@medinadiscovery.bsky.social

Independent and non profit #Research Organization developing innovative programs, collaborations and contracts with academic and industrial partners worldwide. Granada, Spain. medinadiscovery.com

ROBOCOOP-EU is heading to Istanbul! 15–17 Sept 2026 Our first in-person workshop since the project relaunch will bring partners together around: 🔬 Technology & scale-up ♻️ Circular value chains 🤝 Cooperative business models 🌱 Living Labs 📈 Exploitation & impact 🌍 Community of Practice

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En ciencias de la vida, pasar de una idea a un producto es un camino largo y complejo. Fundacion MEDINA puede ser el empuje que muchas empresas necesitan. Olga Genilloud, Directora Científica de MEDINA, nos explica cómo la Fundación actúa como plataforma y catalizador para empresas emergentes

Fundación MEDINA nació en #Granada con una misión clara: convertirse en un referente independiente de I+D e innovación en salud. Pero, ¿por qué Granada? 👇Diego Pozas, Gerente de MEDINA, nos cuenta el origen de la Fundación y el papel que juega hoy en el ecosistema científico y empresarial andaluz.

It was a pleasure to attend ACI Biopesticides Europe 2026 and connect with colleagues, researchers, and industry experts from across the sector. During his presentation, Víctor González-Menéndez, shares MEDINA's insights and contributes to the discussion on innovation in biopesticides.

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🔔 Reminder! The next EUREMAP Seminar Series session co-organised by Fundación MEDINA is happening next Wednesday, May 27! If you haven't registered yet, there is still time: zoom.us/meeting/regi... Don't miss out on the opportunity to hear from Dr. Paul Jensen research on Natural Product Discovery

Welcome! You are invited to join a meeting: MEDINA Seminar Series - Dr. Paul Jensen. After registering, you will receive a confirmation email about joining the meeting.

Welcome! You are invited to join a meeting: MEDINA Seminar Series - Dr. Paul Jensen. After registering, you will receive a confirmation email about joining the meeting.

zoom.us

Fundación MEDINA@medinadiscovery.bsky.social · 5mo ago

📢Save the Date📢 Join us for the next session of the online @euremap.bsky.social Seminar Series, hosted by @medinadiscovery.bsky.social The seminar will feature Dr. Paul Jensen (Scripps Institution of Oceanography, UC San Diego) who will discuss on “Changing paradigms in Natural product discovery"

Excited to share our latest publication in the Journal of Natural Products! This research was carried out within the framework of the HOTBIO project, in collaboration with University of Galway. 🔗 Read the article here: pubs.acs.org/doi/10.1021/...

Sulphopreussomerins: Sulfur-Containing Preussomerins Isolated from the Marine-Derived Fungus Pyrenochaetopsis indica

The organic extract of Pyrenochaetopsis indica CF-301929, a fungal strain collected from the Coral Sea in Australia, showed broad-spectrum activity against the fungal phytopathogens Zymoseptoria tritici, Colletotrichum acutatum, Fusarium proliferatum, and Magnaporthe grisea. After extensive purification, five compounds were isolated, including three new sulfur containing preussomerins 1–3 along with two previously described molecules, ascochytatin (4) and preussomerin G (5). The new compounds incorporate rare thioglycolic or 2-hydroxy-3-mercaptopropionic acid moieties in their structures, and they represent the first members of a new class of preussomerins that we have named sulphopreussomerins. Multiple spectroscopic analyses, including HRESIMS and 1D/2D NMR experiments were used to elucidate their structures while the proposed absolute configuration of compound 1 was assigned by comparison of the experimental and theoretical ECD spectra. When tested against a fungal phytopathogen panel, preussomerin G exhibited, as previously reported, strong antifungal activity and cytotoxicity, whereas sulphopreussomerin A and ascochytatin showed moderate antifungal activity against Z. tritici with no detectable cytotoxicity.

pubs.acs.org

Hit prioritization through orthogonal binding assays. In drug discovery, identifying hits is only the beginning; the real challenge lies in prioritizing them correctly to eliminate false positives and ensure only the most promising candidates move forward.

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From a conventional enzymatic assay to a high-throughput screening platform in weeks. Transitioning an optimized in vitro assay from an academic setting to high-throughput screening requires more than just automation; it demands a fundamental redesign of the assay’s robustness.

The evaluation of metabolic stability is a standard procedure in early drug discovery. However, relying solely on disappearance rates often overlooks the formation of active or reactive metabolites. These unidentified species can cause toxicity, leading to late-stage dropout.

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Last week, our doctoral student Gioele Pecin presented a poster at the Natural Products in the 21st Century conference in #Leuven. He explained how he managed to heterologously express the main genes of the biosynthetic cluster of a new fungal natural product in a black yeast host.

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