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Boston's brand-new Women's Pro Baseball League (WPBL) team, the Hunters, are named after Harriot Kezia Hunt, a practicing physician and the first woman to apply to Harvard Medical School 179 years ago. Read more at: https://www.medpagetoday.com/special-reports/features/122478
Women's Baseball Team Named for Trailblazing Doctor
She was the first woman to apply to Harvard Medical School nearly 200 years ago
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Bone growth among transgender and gender-diverse adolescents slowed compared with peers during pubertal suppression, but partially recovered after starting gender-affirming hormone therapy, an analysis showed. Read more at: https://www.medpagetoday.com/endocrinology/transgender-medicine/122471
Bone Density Appears to Rebound in Transgender Youth After Puberty Blockers Are Done
Meta-analysis turns up partial recovery after gender-affirming hormone therapy is started
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Familiar hospitals dominated the latest "Best Hospitals" rankings from U.S. News & World Report, which also rolled out several changes this year. Read more at: https://www.medpagetoday.com/hospitalbasedmedicine/generalhospitalpractice/122467
Here's Who Topped This Year's 'Best Hospitals' List
More changes made to U.S. News & World Report rankings
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A study of U.S. children found no evidence linking neonatal male circumcision with autism spectrum disorder, prospective data from the ECHO cohort showed. Read more at: https://www.medpagetoday.com/neurology/autism/122465
Circumcision and Autism: What a New Study Found
No link seen in U.S. boys and Tylenol use was uncommon
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It appeared to be the perfect storm: a man in his 30s was learning to surf. As he stood up on the board and twisted to the left for balance, a wave knocked him over. Read more at: https://www.medpagetoday.com/casestudies/emergencymedicine/122464
Surfing Lesson Ends With Unusual Injury
Physician warns it's better to sit on the board while waiting for a wave
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"The mismatch would almost be comical if the stakes were lower." Read the #OpEd from endocrinologist and director of Clinical Research at @pcrm.org Hana Kahleova, MD, PhD, at: https://www.medpagetoday.com/opinion/second-opinions/122446
Opinion | I Prescribe Diet Changes Every Week. Med School Barely Taught Me Anything Relevant.
The nutrition curriculum gap is a choice -- but a fixable one
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"The law does not tolerate an institutional end-run." Read the #OpEd from Richard Hughes IV, JD, MPH, and Will Walters, JD, counsels for the plaintiffs in AAP v. Kennedy, at: https://www.medpagetoday.com/opinion/second-opinions/122435
Opinion | The Emails Show Why We Sued Robert F. Kennedy Jr.
The administration is trying to remake the very machinery of public health
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Only one person has developed a new HIV infection during a year-long extension of the landmark PURPOSE 1 and PURPOSE 2 trials testing twice-yearly injectable lenacapavir (Yeztugo) for pre-exposure prophylaxis (PrEP). Read more at: https://www.medpagetoday.com/meetingcoverage/iac/122449
Long-Acting Lenacapavir Still Delivered Effective HIV PrEP After a Year
Only one person developed HIV infection in year-long extensions of two PURPOSE trials
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Kidney transplant recipients with COVID-19 who received remdesivir (Veklury) early had a lower risk of graft loss, a target trial emulation study found. https://www.medpagetoday.com/infectiousdisease/covid19/122382
COVID Study Supports Antiviral Use in Kidney Transplant Recipients
Target trial emulation links early remdesivir with lower risk of graft failure or death
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"We should let the experiment play out." In an #OpEd, MD candidate and researcher Manav Midha argues for embracing prediction markets in medicine. Read more at: https://www.medpagetoday.com/opinion/second-opinions/122414
Opinion | Can a Betting Market Offer Hope to a Cancer Patient?
As we embrace the power of collective knowledge, we must remember that numbers are just numbers
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The risk of acute kidney injury following elective cardiac surgery was largely reduced with a short course of SGLT2 inhibitor therapy, a Dutch trial found. https://www.medpagetoday.com/cardiology/prevention/122443
Dapagliflozin Makes Good on Preventing Cardiac Surgery-Associated AKI
4 days of the SGLT2 inhibitor lowered the incidence of AKI substantially
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Managing pain with non-opioid options was just as effective as routine pain management with opioids after minimally invasive hysterectomy, a randomized trial showed. https://www.medpagetoday.com/obgyn/generalobgyn/122445
Opioids for Routine Hysterectomies Really Necessary?
More individualized pain prescriptions should be considered, researcher says
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Periurethral application of a smaller amount of estradiol cream with a finger was noninferior to standard intravaginal application with an applicator among postmenopausal patients with recurrent UTIs, the TAPER randomized trial found. https://www.medpagetoday.com/obgyn/generalobgyn/122406
Study on Vaginal Estrogen for UTI Prevention Backs a Less Messy Approach
Periurethral and intravaginal creams both aided prevention of recurrent urinary tract infections
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Healthcare leaders committed to behavioral health "best practices" during an HHS roundtable event on Wednesday, while a key law on insurance coverage for mental health remains in limbo. Read more at: https://www.medpagetoday.com/psychiatry/generalpsychiatry/122418
Health Leaders Pledge Greater Support for Behavioral Health
Meanwhile, enforcement of key mental health parity law remains in limbo
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A treatment regimen anchored by doravirine worked as well as a dolutegravir-based approach but led to significantly less weight gain among patients starting ART for HIV, an open-label randomized trial showed. #AIDS2026 https://www.medpagetoday.com/meetingcoverage/iac/122441
ART Regimen Effective, Led to Less Weight Gain in Treatment-Naive HIV
Findings support alternative regimen to prevent weight gain, possibly modify cardiometabolic risk
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In the wake of a surprise FDA advisory committee vote on Thursday, the third time could be the charm for RP1 (vusolimogene oderparepvec), a melanoma drug candidate that's already been rejected twice by the agency. https://www.medpagetoday.com/hematologyoncology/skincancer/122431
Twice-Rejected Melanoma Drug Gets Love From FDA Panel
Vote at odds with FDA reviewers
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People who consumed less sugar in utero and before age 2 had a lower risk of developing dementia later in life, data from 65,000 U.K. Biobank participants suggested. https://www.medpagetoday.com/neurology/dementia/122400
Sugar Rationing in Early Life Linked to Lower Dementia Risk Decades Later
Long-term study looks at what happened when sugar was scarce
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Oral ralinepag is positioned for potential FDA approval following its strong results as a treatment for pulmonary arterial hypertension in an international phase III trial. https://www.medpagetoday.com/cardiology/generalcardiology/122432
New Drug Prevents Worsening Pulmonary Arterial Hypertension in Major Trial Win
Phase III data favorable for oral ralinepag, a once-daily selective prostacyclin receptor agonist
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A Senate committee plans to vote next week on whether to recommend holding Anthony Fauci, MD, in contempt following a hearing on Wednesday. https://www.medpagetoday.com/washington-watch/washington-watch/122405
Senate Considers Vote to Hold Fauci in Contempt
In contentious hearing, Fauci invoked the Fifth Amendment more than 100 times
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The sodium channel blocker LTG-001, an investigational selective Nav1.8 inhibitor, reduced pain scores more than placebo for 2 days after abdominoplasty, a phase IIb trial showed. https://www.medpagetoday.com/neurology/painmanagement/122394
Sodium Channel Blocker Cuts Post-Surgery Pain
Novel analgesic associated with significantly lower opioid use
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A new online tracking tool from AcademyHealth shows the sprawling scope of recent grant cancellations by the Agency for Healthcare Research and Quality (AHRQ). Read more at: https://www.medpagetoday.com/washington-watch/washington-watch/122429
Tracker Tallies Over $250M in Cancelled Grants From HHS Agency
Nonprofit AcademyHealth has been closely monitoring the cancellations
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Flare prediction can be improved for patients with a common but poorly understood variant of systemic lupus erythematosus by tracking certain biomarkers regularly, researchers proposed. https://www.medpagetoday.com/rheumatology/lupus/122426
Biomarker Trends Predict Lupus Flares for Challenging Subgroup
'Serologically active, clinically quiescent' patients don't always stay that way
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Adding concurrent irinotecan to capecitabine-based chemoradiotherapy failed to improve disease-free survival and other outcomes in patients with locally advanced rectal cancer, a phase III trial showed. https://www.medpagetoday.com/hematologyoncology/coloncancer/122410
Intensified Pre-Op Chemoradiotherapy Fails in Locally Advanced Rectal Cancer
DFS at 3 years nearly identical with the addition of irinotecan, but with more toxicity
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An FDA panel said that trial data did not provide substantial evidence showing that investigational deramiocel was effective in treating cardiomyopathy among patients with Duchenne muscular dystrophy. https://www.medpagetoday.com/neurology/generalneurology/122407
FDA Committee Votes Down Duchenne Drug
Agency staff and drug developer disagree on endpoints
medpagetoday.com
The FDA licensed Ezplaz, the first freeze-dried plasma product available to adults in need of transfusion, on Wednesday. https://www.medpagetoday.com/emergencymedicine/emergencymedicine/122403
FDA Licenses First Freeze-Dried Plasma Product
Ezplaz can be used for life-threatening bleeds in 'austere' settings, agency says
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"Don't dismiss it -- recognize an algorithm may have figured out their unique concerns and fed them the exact piece of information, doubt, or worry that will keep them up at night." Read the #OpEd from Kristen Panthagani, MD, PhD, at: https://www.medpagetoday.com/opinion/second-opinions/122391
Opinion | What Falling Into the Social Media Vortex Taught Me About My Patients
People aren't 'looking' for health information on social platforms, it finds them
medpagetoday.com
Switching to a weekly oral investigational regimen of islatravir and lenacapavir was just as effective as daily oral standard-of-care regimens in patients with virologically suppressed HIV, according to two phase III trials. #AIDS2026 https://www.medpagetoday.com/meetingcoverage/iac/122416
Once-Weekly Drug Combo for Controlled HIV Matches Standard Daily Regimens
Weekly regimen has the potential to address pill fatigue, adherence challenges, researcher says
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Antihistamines hold only a slight benefit for atopic dermatitis (eczema) and shouldn't be routinely used in management, a network meta-analysis concluded. https://www.medpagetoday.com/dermatology/atopy/122393
Antihistamines Panned for Eczema
Network meta-analysis finds no meaningful benefit across the board and some harms
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Four Democratic lawmakers have questioned whether HHS Secretary Robert F. Kennedy Jr.'s family will profit from a sizeable settlement involving Merck's human papillomavirus (HPV) vaccine (Gardasil). Read more at: https://www.medpagetoday.com/washington-watch/washington-watch/122404
Senate Dems Question if RFK Jr.'s Family Will Profit From Vax Settlement
Senators probe HHS Secretary's possible conflicts of interest
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Only a small fraction of patients with primary hyperparathyroidism-associated end-organ damage underwent surgical treatment, a large national cohort study found. @michaelyehmd https://www.medpagetoday.com/endocrinology/thyroid/122401
Surgery Underused for Primary Hyperparathyroidism With End-Organ Damage, Study Says
Large study highlights gap between guidelines and clinical practice
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