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Melé Lab

@melelab.bsky.social

We are the Melé Lab, the Transcriptomics and Functional Genomics Lab (TFGL) at the Barcelona Supercomputing Center (BSC). Account by lab members

26 Posts159 Follower248 Folgt
Guigó Lab@guigolab.bsky.social · 8mo ago

Thrilled to share! 🧬🌍 Our 800M+ long-read RNA-seq dataset from 8 diverse populations reveals big gaps in gene annotations for non-European transcripts. Let’s build global inclusive annotations. @bsc-cns.bsky.social @crg.eu @melelab.bsky.social www.nature.com/articles/s41...

Long-read transcriptomics of a diverse human cohort reveals ancestry bias in gene annotation - Nature Communications

Current human gene annotations are predominantly based on individuals of European ancestry. Here, the authors use long-read RNA sequencing across diverse human populations to reveal ancestry-specific ...

nature.com

Centre de Regulació Genòmica (CRG)@crg.eu · 8mo ago

Human gene maps contain major blind spots that leaves out a vast majority of the world's biological diversity, according to a new study led by the CRG's @rodericguigo.bsky.social with @bsc-cns.bsky.social. The researchers uncovered tens of thousands of new transcripts and entirely new genes.

Long-read transcriptomics of a diverse human cohort reveals ancestry bias in gene annotation - Nature Communications

Current human gene annotations are predominantly based on individuals of European ancestry. Here, the authors use long-read RNA sequencing across diverse human populations to reveal ancestry-specific ...

nature.com

Melé Lab@melelab.bsky.social · 8mo ago

📣 Yesterday our study uncovering the ancestry bias in gene annotations was finally published in @natcomms.nature.com! www.nature.com/articles/s41... If you work in human genetics or transcriptomics, do not miss our tweetorial!👇 @guigolab.bsky.social @bsc-cns.bsky.social @crg.eu

Long-read transcriptomics of a diverse human cohort reveals ancestry bias in gene annotation - Nature Communications

Current human gene annotations are predominantly based on individuals of European ancestry. Here, the authors use long-read RNA sequencing across diverse human populations to reveal ancestry-specific ...

nature.com

Melé Lab@melelab.bsky.social · last yr.

Do you work in 💫human genetics💫? Have you ever worried about what’s inside your gene annotation GTF⁉️ WELL, YOU SHOULD! 😱 Especially when studying a genetically diverse 🌍 cohort! 🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses! Don't miss this thread🧵⬇️ 1/13

Winona Oliveros@oliveroswinona.bsky.social · last yr.

Excited to share our new preprint: The impact of sex, age, and genetic ancestry on DNA methylation across tissues. Briefly, we explored how sex, age, and genetic ancestry shape DNA methylation across tissues and individuals. Want to know a bit more? Follow this “bluetorial”! doi.org/10.1101/2025...

The impact of sex, age, and genetic ancestry on DNA methylation across tissues

Background: Understanding the consequences of individual DNA methylation variation is crucial for the study of human biology and disease. However, the collective impact of demographic traits on DNA me...

biorxiv.org

Melé Lab@melelab.bsky.social · last yr.

Do you work in 💫human genetics💫? Have you ever worried about what’s inside your gene annotation GTF⁉️ WELL, YOU SHOULD! 😱 Especially when studying a genetically diverse 🌍 cohort! 🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses! Don't miss this thread🧵⬇️ 1/13

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

biorxiv.org

Melé Lab@melelab.bsky.social · last yr.

Really interesting talk by our talented PhD student @mariasopenarios.bsky.social at #WomensHealth2025 conference!

Maria Sopena Rios@mariasopenarios.bsky.social · last yr.

Last week, I presented my work on sex differences in immune aging at the Women's Health conference, @eventswcs.bsky.social. Great discussions and inspiring science highlighting the need for more research with a gender and sex perspective! #WomensHealth2025 @melelab.bsky.social @bsc-cns.bsky.social