87 PD patients completed the study evaluating cannabis-based oil for pain and other non-motor symptoms No significant differences were observed between the CBD/THC and placebo groups Access the article movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Background There is a lack of treatments for non-motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and...

movementdisorders.onlinelibrary.wiley.com

Interesting approach for mobility in Parkinson’s disease with music cueing clinicaltrials.gov/study/NCT07705373 Study will show if personalized music cueing through a digital device (movive.com) can improve walking quality, ability, daily walking amount and intensity

The real bottleneck in making a novel medicine is disease understanding: identifying a biological mechanism whose modification actually changes the course of disease in patients. www.a16z.news/p/drug-disco...

Drug Discovery Has No Magic Wands

On AI, human biology, and what it will actually take to discover transformative new medicines

a16z.news

Brain Shuttles: A Coming Boom? www.alzforum.org/news/confere...

aspenneuroscience.com/aspen-neuros...

Aspen Neuroscience Receives FDA Regenerative Medicine Advanced Therapy (RMAT) Designation for Sasineprocel (ANPD001) to Treat Parkinson’s Disease

Aspen Neuroscience, Inc., a clinical-stage regenerative medicine biotechnology company developing personalized, autologous cell therapies, today announced that sasineprocel (ANPD001), its lead investi...

aspenneuroscience.com

RET regulation represents a previously unrecognized normal function of tau that becomes pathological in disease, providing a new therapeutic target. www.cell.com/neuron/fullt...

Tau-induced mitochondrial reverse electron transport drives neurodegeneration

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

cell.com

Great review covering recent drug development efforts in Parkinson’s Disease One of the visuals: α-synuclein targeting disease-modifying trials in PD pubmed.ncbi.nlm.nih.gov/42162439/

A great systematic overview of the pathogenesis of cough hypersensitivity, with a particular focus on the neuro-immune axis, offering a theoretical framework for personalized treatment www.frontiersin.org/journals/med...

Frontiers | Unraveling the neuro-immune axis in cough hypersensitivity: from pathogenesis to synergistic management

Cough Hypersensitivity Syndrome (CHS) stands as the definitive pathological phenotype of refractory chronic cough, characterized by a sensory nervous system ...

frontiersin.org

Great review covering recent drug development efforts in Parkinson’s Disease One of the visuals: α-synuclein targeting disease-modifying trials in PD pubmed.ncbi.nlm.nih.gov/42162439/

A team from Revel Pharmaceuticals, Calico and CU Anschutz just published an enzyme that removes a form of chemical aging damage previously considered permanent Nature Communications, July 2026 → The claim isn't "slowed accumulation" It's reversal of damage

One study indicated that cough severity was associated with workplace productivity loss. Cough burden in progressive pulmonary fibrosis: a systematic review with narrative synthesis link.springer.com/article/10.1...

One study indicated that cough severity was associated with workplace productivity loss. Cough burden in progressive pulmonary fibrosis: a systematic review with narrative synthesis link.springer.com/article/10.1...

Really interesting concept Biodegradable Smart Face Mask for Cough Acoustic Sensing pubs.acs.org/doi/10.1021/...

Beyond fingerprint and voice print: cough sequence sound for identity verification | npj Health Systems www.nature.com/articles/s44...

Beyond fingerprint and voice print: cough sequence sound for identity verification - npj Health Systems

npj Health Systems - Beyond fingerprint and voice print: cough sequence sound for identity verification

nature.com

Built a personalized app for my wife Kanji and kana practice with a custom set of words of interest: niche food specialties, Geiko/Maiko daily life, Tale of Genji etc iPad pencil stroke order practice (watch / guided / trace) A reactive matcha buddy in-app Thanks, Claude

If you’re at #AAIC in London starting this weekend, and curious about precision digital endpoint measures (motor and cognitive) - I look forward to connecting on Monday or Tuesday!

Validation Approaches for Cough Monitoring Tools: A Scoping Review link.springer.com/article/10.1...

Validation Approaches for Cough Monitoring Tools: A Scoping Review - Lung

Objective To characterize validation approaches used in ambulatory cough monitoring systems and identify methodological variability that may limit clinical and research applications. Study Design Scop...

link.springer.com

'As music is the poetry of sound, so is painting the poetry of sight’. James McNeill Whistler

Digital biomarkers should not only aim to become primary endpoint measures. There’s immense potential value to clinical drug development beyond primary endpoint status: ->reducing screen-failure rate ->interim marker of early termination ->pre-screening for placebo response

Cough biomarkers for diagnosis and monitoring of respiratory disease: a systematic review publications.ersnet.org/content/erre...

Clinically Meaningful Differences for Cough-Specific Visual Analogue Scale in Chronic Cough: A Real-World Study | Lung | Springer Nature Link link.springer.com/article/10.1...

Clinically Meaningful Differences for Cough-Specific Visual Analogue Scale in Chronic Cough: A Real-World Study - Lung

Background Cough-specific visual analogue scale (VAS) is widely used to assess cough severity and frequency; however, clinically meaningful thresholds for treatment response in chronic cough (CC) rema...

link.springer.com

AusculPatch is taped to the chest, over peripheral arteries - continuously captures subtle vibrations produced by the heart, lungs, blood flow, and pulse waves Are patch devices really suitable for continuous measures? Doubting due to discomfort by many www.mobihealthnews.com/news/anz/aus...

Australian engineers develop wearable steth patch for remote monitoring

AusculPatch, which records heart, breathing and pulse signals, is set for AI-assisted deterioration detection testing.

mobihealthnews.com

Converting a Cough Counter into a Cough Monitor: A Way Forward? www.mdpi.com/2076-3271/14...

Moving Beyond Responders A Post Hoc Analysis Identifying Criteria for Chronic Cough Control journal.chestnet.org/article/S001...

Moving Beyond Responders

Our results show that we derived the following patient-anchored criteria for cough control incorporating objective and subjective outcomes: 24-hour CF of ≤ 10 coughs/h, CS-VAS of ≤ 30 mm, and LCQ scor...

journal.chestnet.org

Intralesional PD-1 blockade for oral cancer prevention: First-in-class phase 1 trial. www.asco.org/abstracts-pr...

Going through some ASCO abstracts, seems like the trend in personalized cancer vaccines is generally vaccine + pembrolizumab Moderna’s trial in resected melanoma pts did it, another example in glioblastoma here www.asco.org/abstracts-pr...

Daraxonrasib’s name is a clever one: Darax-ON-RAS-IB It reflects a “molecular glue” that locks RAS with Cyclophilin A, binding RAS in its ON state to inhibit both wild-type and mutant forms

The therapeutic potential of orphan adhesion G-protein-coupled receptors www.nature.com/articles/s41...

The therapeutic potential of orphan adhesion G-protein-coupled receptors - Nature Reviews Drug Discovery

Adhesion G-protein-coupled receptors (aGPCRs) have been implicated in multiple human pathologies, yet no drugs targeting these receptors are currently approved. This Review provides an overview of the...

nature.com

In this article, we reviewed the literature and summarised insights gained from continuous cough monitoring across various diseases, and discussed future directions for this emerging field. jtd.amegroups.org/article/view...

The value of continuous cough monitoring: a narrative review

The value of continuous cough monitoring: a narrative review

jtd.amegroups.org

The opportunity of wearables for women health is huge: from earlier detection in pregnancy and perimenopause, to reducing diagnostic delays in conditions like endometriosis. Getting there requires validation, clinical rigour, and inclusive innovation. www.nature.com/articles/s41...

Wearables and women’s healthtech: advancing measurement, monitoring and action via digital medicine - Nature Reviews Disease Primers

Wearables have the potential to address one of medicine’s major blind spots: the under-representation of women. They could help to close this gap by advancing measurement and monitoring into clin...

nature.com