Fresh from #ASCO2025 meetings.asco.org/abstracts-pr... SBRT vs microwave ablation (MWA) in pts with CRC liver oligo-mets ➡️ n=100, n=92 treated (39 SBRT, 53 MWA) ➡️ 18/92 pts (20%) reported side effects ➡️ n=3 G3-4 pain; n=2 infections after open MWA, n=1 bowelperforation after percutaneous MWA

Neoadjuvant chemo-IO for Borderline Resectable & Unresectable Stage III NSCLC Conclusion of authors: "high rates of surgical resectability" Pts with completed surgery: III A: 65/79 - 82% III B: 16/27 - 59% III C: 3/6 - 50% -> careful interpretation needed jamanetwork.com/journals/jam...

PD-1 and PD-L1 Blockade With Chemotherapy for Borderline Resectable and Unresectable Stage III Non–Small Cell Lung Cancer

This cohort study evaluates the efficacy of neoadjuvant programmed cell death 1 protein (PD-1) or programmed cell death 1 ligand 1 (PD-L1) blockade combined with chemotherapy in enhancing surgical out...

jamanetwork.com

🔥 SAVE THE DATE 🔥 ❓ What is the population-health effect of novel anti-cancer drugs ❓ How do anti-cancer drugs compare to other drugs and health services ❓ How to improve sustainability of cancer care and medicine in the future Virtual Grand Rounds in Radiation Oncology www.usz.ch/veranstaltun...

Thought provoking ! Population-health impact of new drugs recommended by NICE in England during 2000–20 - quality-adjusted life-years and incremental cost-effectiveness ratio used for analysis 👉 overall NEGATIVE (!) cumulative impact 👉 data for #radonc ? www.thelancet.com/journals/lan...

Retrospective multicenter study of SBRT for pulmonary oligometastatic HNSCC - 16 centers, 178 pts, 284 pulmonary mets - 1a local failure rate 5.5% - no grade 4/5 toxicities 👉 supporting prospective evaluation, in preparation by EORTC & P Balermpas www.redjournal.org/article/S036...

Aiming to refine your #radonc in 2025 ! Offer RT for low-volume metastatic PC, only ? What benefit of RT is to be communicated to pts & colleagues ? How about SBRT or surgery ? Virtual Grand Rounds in Radiation Oncology Jan 8th / 17:00 - 17:30 CET Dr Alberto Bossi 👇 www.usz.ch/veranstaltun...

Virtual Grand Rounds in Radiation Oncology Let`s start 2025 with another highly-important lecture Jan 8th 2025 - 17:00 - 17:30 Dr. Alberto Bossi Radiotherapy of the primary in metastatic prostate cancer - insights from PEACE-1 Link 👇 www.usz.ch/veranstaltun...

Season's Greetings

Safe practice of spine SBRT requires high-quality data about SC dose tolerance - Cohort study 2051 pts - 30 cases of RM, 19 of which G3 to G4 - 2a rate of G1-4 RM 1.8% - cord dose D0.1cc of 19.1Gy / Dmax of 20.8Gy = 1.0% risk of G3 to G4 RM at 2 years jamanetwork.com/journals/jam...

Radiation Myelitis After Hypofractionated Spine Stereotactic Body Radiation Therapy

This cohort study characterizes the risk of radiation myelitis after spine stereotactic body radiation therapy to update the current dosimetric constraints.

jamanetwork.com

Todas is HCC day! - RTOG 1112 - HCC unsuitable for or refractory to local-regional Tx (n=177) - SBRT & Sorafenib vs Sorafenib - After adjustment for stratification factors, improved OS after SBRT (HR 0.72) - Median PFS improved from 5.5 to 9.2 mo (HR 0.55) jamanetwork.com/journals/jam...

Stereotactic Body Radiotherapy vs Sorafenib Alone in Hepatocellular Carcinoma

This phase 3 randomized clinical trial evaluates whether stereotactic body radiation therapy improves outcomes in patients with locally advanced hepatocellular carcinoma compared with sorafenib alone.

jamanetwork.com

And yet another prospective trial confirming excellent efficacy of SBRT for localized HCC - n=36 pts - median tumor size 2.3 cm - median FU 49 mo - 3-year local control rate 93% - Grade 3 AE 11% www.redjournal.org/article/S036...

Matthias Guckenberger@mguckenberger.bsky.social · 2y ago

Randomized comparison of SBRT vs RFA for recurrent small HCC (n=166 pts) 👆 Freedom from local progression significantly improved after SBRT: 2a 92.7% vs 75.8%, HR=0.45 ! 👉 No difference in PFS (median 37.6 vs 27.6mo) and OS (2a 97.6% vs 93.9%) 👍 ascopubs.org/doi/10.1200/...

Randomized comparison of SBRT vs RFA for recurrent small HCC (n=166 pts) 👆 Freedom from local progression significantly improved after SBRT: 2a 92.7% vs 75.8%, HR=0.45 ! 👉 No difference in PFS (median 37.6 vs 27.6mo) and OS (2a 97.6% vs 93.9%) 👍 ascopubs.org/doi/10.1200/...

Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Recurrent Small Hepatocellular Carcinoma: A Randomized, Open-Label, Controlled Trial

PURPOSETo assess the efficacy and safety of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in treating recurrent small hepatocellular carcinoma (HCC).METHODSIn this trial, ...

ascopubs.org

Remember the misleading press about "brutal" #radonc after PROSPECT ? This is what modern RT can achieve for elderly breast cancer patients ! 👉 "Endocrine Tx was associated with a greater reduction in HRQOL compared with RT at 24 mo" 👉 oncological data awaited www.thelancet.com/journals/lan...

ESTRO power team ! Anna Kirby and Barbara Jereczek-Fossa as past-president and president-elect Thanks you so much for your 💪 collaboration, friendship and dedication, to 👉 advance multidisciplinary cancer care 👉 elevate radiation oncology 👉 develop ESTRO society

Radiation Oncology is characterized by rapid innovation Dissemination & implementation are important aspects to bring this progress to our cancer patients in daily practice Well written review by Erin Gillespie and colleagues 👇 www.redjournal.org/article/S036...

In case you may have missed any of the Virtual Grand Rounds in Radiation Oncology lectures Recordings are 👇 youtube.com/playlist?lis... Endorsed by: ESTRO DEGRO SASRO

Virtual Grand Rounds in Radiation Oncology „Revving Up Gastric Cancer Care: Insights from the TOPGEAR Trial” Presented by Prof. Karin Haustermans December 4th 17:00 – 17:30 Link to online meeting 👇 www.usz.ch/veranstaltun... Endorsed by: ESTRO DEGRO SASRO

ESTRO Scientific Council Meeting in Brussels Hopefully in brighter colors than todays sky …

ETH Zürich Polyball Zwischen Göttern und Menschen Preparations almost finished

PEACE-1 trial of prostate radiotherapy in mHSPC. Improvement in rPFS when used in addition to ADT and abiraterone. Medsky. Oncsky.

PEACE-1 published Radiotherapy of the prostate in metastatic pts prevents serious GU complications, in pts with low and high tumor burden How to select patients? - all ? - based on live expectancy ? - response to systemic Tx ? - prostate volume ? www.thelancet.com/journals/lan...

Efficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design

Combining radiotherapy with standard of care plus abiraterone improves radiographic progression-free survival and castration resistance-free survival, but not overall survival in patients with low-vol...

thelancet.com

Curious about #RadiationOncology on BlueSky Warm welcome to all colleagues and friends !