Hello Boston! The lab is delighted to be at #ASHG25🧬 Check out our talks over the next few days - all unpublished stories. Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc Also 👇

Excited to be presenting our work on "Saturation mutagenesis of 37 human splicing factor genes using pooled prime editing" later today at #ASHG2025 during the Platform Session "RNA Functions Beyond Coding Sequences" (1:30-2:30PM, Room 205ABC).

Check out @ckajba.bsky.social and Michael Herger's concise description of their recent work. Thanks to Nature Reviews Genetics for featuring this. rdcu.be/eraxZ

Determining variant effects with pooled prime editing

Nature Reviews Genetics - In this Tools of the Trade article, Christina Kajba and Michael Herger describe their screening platform, based on pooled prime editing, for large-scale functional...

rdcu.be

Delighted our work on the development of a prime editing screening platform in HAP1 is now published in Cell Genomics. This was led by Christina Kajba and Michael Herger, who did very well to optimise all aspects. (Preprint thread: x.com/TheGenomeLab...) www.cell.com/cell-genomic...

High-throughput screening of human genetic variants by pooled prime editing

Herger and Kajba et al. introduce a prime editing platform to screen genetic variants for functional effects in haploid human cells. Negative and positive selection screens identify loss-of-function v...

cell.com