Appreciative of the opportunity to discuss the impact of human genetics and genomics research.

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · 2mo ago

The ASHG Program Committee brought the power of human genetics and genomics research to Capitol Hill, where they shared how the work you do and resources like the All of Us Research Program are advancing medicine and strengthening public health.

Emma et al's preprint is now published! We identify a chronic transcriptional response signature in cardiomyocytes a week after Doxorubicin treatment that can be used to design biomarkers or therapeutic targets for DOX-induced cardiotoxicity. doi.org/10.1093/g3jo...

Progressive suppression of DNA repair genes with persistent p53 target activation in doxorubicin-treated cardiomyocytes

Abstract. Doxorubicin (DOX) is an effective anticancer drug; however, it can cause cardiotoxicity by inducing DNA double-strand breaks in cardiomyocytes. C

doi.org

Come and share your research and connect with the global human genetics and genomics community at #ASHG26 in Montreal Oct 20-24. Abstracts due May 18th (ashgmeeting.ashg.org/programs/abs...)

Pre-print on cardiomyocyte response to novel anti-cancer drug CX-5461 now published! Includes new gene expression response data at higher CX doses. Response to micromolar CX doses starts to mimic DOX responses, suggesting that off-target effects on the heart should be considered for this drug.

CX-5461 and doxorubicin activate a shared DNA damage-associated transcriptional response in human cardiomyocytes

Abstract. CX-5461 (CX) is under investigation for the treatment of late-stage cancers. While CX was first described as an RNA polymerase I inhibitor, it ha

academic.oup.com

Our latest work led by MD/PhD student Omar: ‘Conserved RNA-protein modules link early anthracycline responses to atrial fibrillation risk’. [1/6] www.biorxiv.org/content/10.6...

Happy to share graduate student Emma’s first paper: ‘Progressive suppression of DNA repair genes with persistent p53 activation in Doxorubicin-treated cardiomyocytes’. [1/6] www.biorxiv.org/content/10.6...

We're hiring for multiple open rank positions in the broad areas of biochemistry, molecular biology, and computational biology. With the recruitment of a new chair our Departmental strengths now include nuclear architecture, genomics and ancient DNA. jobs.sciencecareers.org/job/676677/b...

Biology Faculty Opportunities (Open Rank) - Galveston, Texas job with University of Texas Medical Branch | 676677

The Department of Biochemistry and Molecular Biology at UTMB Health invites applications for multiple tenure-track positions at all ranks; assistant,

jobs.sciencecareers.org

To showcase science you’re interested in seeing at ASHG26 in Montreal, submit a proposal for a Featured Symposium. Deadline is Jan 20th. Topics of interest include ‘evolutionary approaches to biological and clinical insights from phylogeny or recent human/primate lineages'.

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · 10mo ago

Lead the next conversation in #HumanGenetics! Submit a proposal for Featured Symposia or an Interactive Workshop for the chance to redefine discussions on model organisms, clinical care, ethical AI, & more. Help shape what’s next—Submit by Jan 20, 2026: https://www.ashg.org/annual-meeting-2026/

Our preprint on chromatin accessibility changes in response to DNA-damaging agents in cardiomyocytes is now published. Congrats to Renee et al and two first time co-authors! [1/3] journals.plos.org/plosgenetics...

Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci

Author summary Anthracyclines are a widely used class of breast cancer drugs that are linked to cardiac toxicity and the development of heart disease in some women. There are hundreds of genetic varia...

journals.plos.org

Happy to be at ASHG! 2 students in the lab will present posters on gene regulatory evolution in primates on Thurs: Emma focuses on responses to stimuli: 9109T John focuses on transposable elements: 6036T Please stop by if interested #ASHG25

Project led by Sayan investigating the effects of CX-5461, an anti-cancer drug currently in clinical trials, on cardiomyocytes: ‘Topoisomerase II inhibitors CX-5461 and Doxorubicin differ in their cardiotoxicity profiles.’ [1/4] www.biorxiv.org/content/10.1...

Happy to share our work led by Renee: ‘Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci.’ www.biorxiv.org/content/10.1...

Happy to share the published version of Omar & Sayan’s paper. We generated a DNA-damage-associated cardiomyocyte protein co-expression network to gain insights into tolerance to genetic variation and disease. www.sciencedirect.com/science/arti...

Come join us at #ASHG25 in Boston Oct 14-18! Abstract submission site (ashg.org/submit) is now live. Abstracts due June 9th.