#MicroSky: High-copy expression can overwhelm the ER—but shi et al found a way forward. In Komagataella phaffii, engineering key UPR regulators boosted secretion of recombinant proteins by up to 46%, advancing a more robust chassis for Synthetic Biology and biomanufacturing. doi.org/10.1111/1751...

#MicroSky: Synthetic biology toolbox expansion for probiotic Lacticaseibacillus rhamnosus. Direct plasmid cloning, a strong promoter, and engineering fluorescent strains, open new chances for studying host–microbe interactions and developing probiotic cell factories. doi.org/10.1111/1751...

#MicroSky: Pseudomonas KT2440 grows on polyethylene-derived long-chain alcohols, and adaptive evolution rapidly boosts this ability. Expressing the outer-membrane transporter AlkL shows membrane permeability as a key lever for engineering microbes to upcycle plastics. doi.org/10.1111/1751...

#MicroSky: Fungal metabolism: Deleting NADPH dehydrogenase genes in Podospora reshapes fungal metabolism: boost fruiting body formation, alter redox balance, increase oxidative stress sensitivity, and rewire energy and lipid metabolism. By Qiu et al doi.org/10.1111/1751...

#MicroSky: A heterologous T3SS transforms P. protegens Pf-5 into a programmable molecular syringe, delivering Bg9562 into Fusarium hyphae to suppress disease, boost rhizosphere colonization, & protect tomato plants from wilt. A promising modular platform for fungal biocontrol doi.org/10.1111/1751...

#MicroSky: 5-year journey of IMiLI-SAC in advancing Microbiology Literacy & translating Microbiome science into society. Through outreach, multilingual resources & education, we connect microbes with health, sustainability, etc.: building an informed & healthier future. doi.org/10.1111/1751...

#MicroSky: PLANT/MICROBES INTERACTIONS. Plants and microbes communicate in unexpected ways. Soybean flavonoids trigger the formation of wall-deficient cells in Streptomyces, revealing a link between plant metabolites and bacterial morphology. Learn on biotech applications at. doi.org/10.1111/1751...

#MicroSky: SYNTHETIC BIOLOGY. How do microbes respond to electricity? Al Sbei et al show that microbial electrosynthesis drives Clostridium ljungdahlii into a unique physiological sate, offering new insights into carbon capture, energy storage and biomanufacturing. Don’t miss doi.org/10.1111/1751...

#MicroSky: Cancer Research: Microbial genetics can transform cancer diagnostic. Xi et al identified thousands of E. coli SNOs associated with colorectal cancer, enabling a highly accurate, non-invasive risk prediction model. Don’t miss doi.org/10.1111/1751...

#MicroSky: PLANT HEALTH: Can bacteriophages protect oak trees? Grace et al doi.org/10.1111/1751... isolated the first phages targeting bacteria linked to acute oak decline. While promising in the lab, field assays highlight the complexity of applying phage therapy in natural environments.

#MicrosKY: VACCINES: A new nanoparticle vaccine platform against West Nile virus shows strong immune responses, scalability and safety. Built on bacterial expression systems, the novel approach can accelerate affordable vaccine development against multiple viruses. Byun et al doi.org/10.1111/1751...

#MicroSky: Scientific academies are more than honor societies; they are public institutions with a responsibility to lead. In an era of climate change, inequality, declining trust in science, evidence-based leadership has never been so important. Timmis et al doi.org/10.1111/1751...

#MicroSky: From Antarctica comes a new discovery by Kralova et al doi.org/10.1111/1751.... They identified kineochelins, an unknown group of siderophores produced by rare actinomycetes. A new step toward uncovering new bioactive compounds and antimicrobials.

#MicroSky: MBT has achieved a CiteScore of 9.4! We’re thrilled to rank in the top 15% of the areas of Applied Microbiol & Biotechnol and Biochemistry, Genetics & Mol Biol. THANKS to our readers, authors, staff & editors for their unwavering support!

#MicroSky: SCIENCE COMMUNICATION: Microbes shape our world, yet they are often misunderstood. Bakteriopolis is bringing the hidden microbial world directly to communities through interactive exhibits, hands-on activities and dialogue with scientists. Read Friebel et al doi.org/10.1111/1751...

#MicroSky: ONE HEALTH: Cutibacterium acnes extracellular vesicles promote ovarian tumor growth by activating the KEAP1–NRF2 axis and suppressing ferroptosis. RSL3 reversed these effects, highlighting microbial EVs therapeutic targets in EOC. Learn more. doi.org/10.1111/1751...

#MicroSky: BIOREMEDIATION In the environment, bacteria sense aromatic pollutants, move to them, adapt to toxicity, & use specialized uptake & catabolic systems. Genomic plasticity, metabolic versatility & division of labor within populations aid to remove persistent chemicals doi.org/10.1111/1751...

#MicroSky: Kim et al (doi.org/10.1111/1751...) improved microbial chemical production by combining genomic libraries with fluorescent biosensors. They identified genes involved in 3-HP import & locking product re-uptake boosted 3-HP titers by 21%, advancing smarter microbial cell factories.

#MicroSky: SYNTHETIC BIOLOGY. Kato et al (doi.org/10.1111/1751...) engineering bacterial P450 into an H₂O₂-driven biocatalyst boosting activity 28-fold & enabled efficient synthesis of valuable compounds, including indigo dye. A simple, powerful strategy to expand sustainable enzyme-driven chemistry

#MicroSky: Machine learning meets microbiome science: optimized amino acid formulations for Bifidobacterium longum reduced nutrient inputs by up to 77% while maintaining growth. Kaneco et al reveal key amino acids shaping fitness and enables streamlined media design. doi.org/10.1111/1751...

#MicroSky: Science conversations are evolving. By analysing interactions on X and BlueSky, Bernal et al highlight the microbiology and biotechnology topics our community cares about most: from precision medicine to synthetic biology and sustainability. doi.org/10.1111/1751...

#MicroSky: Park et al present ways for fighting antibiotic resistance by targeting bacterial persisters. bymBDZ accelerates persister regrowth & increases antibiotic susceptibility in E. coli, boosting killing during early recovery. A promising strategy to prevent relapse. doi.org/10.1111/1751...

#MicroSky: A greener future for bioplastics: near-solvent-free recovery of microbial PHAs directly from wet biomass using insect-derived enzymes. High polymer recovery & material quality, & up to 7× lower carbon footprint without drying or toxic solvents. Read Bogojevic et al doi.org/10.1111/1751...

#MicroSky: GREEN CHEMISTRY: Succinic acid is key for sustainable green chemistry, but cost & sustainability challenges limit scale-up. Gunkel and Blombach explore next-generation feedstocks, low-pH fermentations & novel yeasts to advance competitive succinic acid production. doi.org/10.1111/1751...

Excessive paperwork and inefficient systems are sabotaging scientific progress. Really proud to be part of this global manifesto spearheaded by @kentimmis.bsky.social. We need action at all levels to tackle the root causes. Our analysis & proposals @microbiotech.bsky.social: doi.org/10.1111/1751...

Scientists' Warning to Humanity: Unnecessary Bureaucracy Is a Global Impediment to Productivity, Advancement of Human and Planetary Wellbeing, Science and Sustainability

Unnecessary bureaucracy is a global impediment to progress and productivity that increases stress and lowers workplace morale and motivation. In research it smothers creativity and innovation that ar....

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#MicroSky: Adapting Bacteria for Better Bioremediation. Evolving Dehalobacter on mixed substrates boosts 1,1-DCA dechlorination. Key mutations in TmrA enhance binding to xenobiotic pollutants, a new path to engineer more efficient cleanup microbes. Read Ren et al doi.org/10.1111/1751...

#MicroSky: Engineering Better Fucosylation with Enzyme Design. MBT ( doi.org/10.1111/1751...) presents a study led by Patricie Vodičková, that boosts transfucosylation >20× via a single mutation (S237V), enabling precise synthesis of fucosyllactose derivatives for biosensors and diagnostics.

#MicroSky: Better Biosensors: Engineering Geobacter biofilms via cGAMP signaling enhances electron transfer, creating thinner, more conductive films. Result: a 20× improvement in Cd(II) detection sensitivity, hence advancing bioenergy and biosensing tech. By Zhang , Han et al doi.org/10.1111/1751...

#MicroSky: Wastewater: Prototheca, rare pathogenic microalgae, are widespread in wastewater (78% samples). Treatment cuts levels by up to 99.9%, yet detectable cells remain, highlighting WWTPs as potential release routes & the need for routine monitoring + safety guidelines. doi.org/10.1111/1751...

#MicroSky: Healthcare systems are failing on access, equity, and resilience. Timmis et al propose a bold reset: patient-driven digital care, microbial tech innovation, and a shift to prevention, reframing healthcare as a public good, not a commodity. Learn more doi.org/10.1111/1751...