Many dynein teams collectively generate high forces during the transport of large organelles. Simon Wieland, Christina Steininger, David E. Gitschier, Marius M. Kaiser, Wolfgang Gross, Abdullah R. Chaudhary, Jana Ritschar, Christian Laforsch, Adam G. Hendricks,and Holger Kress.

Many dynein teams collectively generate high forces during the transport of large organelles

The transport of organelles is important to maintain cellular organization and function. Efficient retrograde transport of large organelles with a size of several micrometers requires high collective…

cell.com

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment: iScience www.cell.com/iscience/ful...

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment

Molecular network; Molecular neuroscience; Cellular neuroscience

cell.com

Our recent work showing that tau phosphorylation alters cooperative binding and organelle transport in neurons is now posted at @elife.bsky.social. A big thanks to the reviewers and editors for their thoughtful assessment. doi.org/10.7554/eLif...

Adam Hendricks@mindonmotors.bsky.social · last yr.

A few highlights from our new preprint: On taxol-stabilized microtubules In vitro, wild-type (WT) and phosphor-resistive (AP) tau form well-defined envelopes, while phosphomimetic (E14) tau does not bind cooperatively.

Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)

A few highlights from our new preprint: On taxol-stabilized microtubules In vitro, wild-type (WT) and phosphor-resistive (AP) tau form well-defined envelopes, while phosphomimetic (E14) tau does not bind cooperatively.

Adam Hendricks@mindonmotors.bsky.social · last yr.

Very happy to share our latest work on tau. We show that tau binds cooperatively in living neurons. Phosphorylation disrupts tau envelopes, and misregulates axonal transport. www.biorxiv.org/content/10.1...

Very happy to share our latest work on tau. We show that tau binds cooperatively in living neurons. Phosphorylation disrupts tau envelopes, and misregulates axonal transport. www.biorxiv.org/content/10.1...

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

Tau, a neuronal microtubule-associated protein (MAP), organizes the axonal cytoskeleton and regulates intracellular transport. Tau hyperphosphorylation is closely linked to neurodegeneration in tauopa...

biorxiv.org

Steven M. Block | 2025 Benjamin Franklin Medal in Life Science fi.edu/en/awards/la... youtu.be/yeZJXeQo3JQ?... via @YouTube

Steven M. Block

fi.edu

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

DMartin@drddom.bsky.social · last yr.

Missed the deadline for the abstract submission for the CSMB meeting on Protein Homeostasis – From Basic Science to Human Health? Well the deadline was extended until April 15th! event.fourwaves.com/csmb-prince-...

Competition for microtubule lattice spacing between a microtubule expander and compactor. https://www.biorxiv.org/content/10.1101/2025.02.28.640185v1