How do dendritic cells control tertiary lymphoid structures in cancer? Raphaël Mattiuz just showed us how–just out in @science.org Happy I could contribute to this important piece. @miriammerad.bsky.social www.science.org/doi/10.1126/...

Dendritic cells control tertiary lymphoid structure development and maintenance in cancer

Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multipl...

science.org

hello world. Excited to launch the Ingelfinger Lab account! We’re a young lab in Germany’s Black Forest tackling key questions in immunology with innovative single-cell technologies. Follow us for updates on systems immunology, machine learning & translational oncology. fi

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c.org

Thrilled our Perspective in @nataging.nature.com is out! With Matthew D Park et al., we spotlight how aging reshapes RTMs and skews myelopoiesis–with consequences for healthy aging and cancer @miriammerad.bsky.social www.nature.com/articles/s43...

Restoring resident tissue macrophages to combat aging and cancer - Nature Aging

Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...

nature.com

New preprint out! 🚀Spearheaded by @chiarafalcomata.bsky.social we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC

Chiara Falcomatà@chiarafalcomata.bsky.social · last yr.

🚨 Our new #preprint is out! doi.org/10.1101/2025... We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)

First lab Bluesky post! Happy to share new papers: PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac... PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...

Ovarian cancer-derived IL-4 promotes immunotherapy resistance

Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment, promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating from a minority ...

cell.com

Very honored to be inducted at the Belgian Royal Academy of Medicine this weekend alongside incredible colleagues. Thank you again to the Academy for honoring my laboratory. It was also refreshing to spend time with like-minded peers amidst all the chaos,

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

Nutrient-driven histone code determines exhausted CD8+ T cell fates

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

science.org

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...