Yesterday was #WorldHepatitisDay — a day to raise awareness of viral hepatitis and to highlight the importance of prevention, diagnosis, and research. This is a great reason for us to celebrate our new study! Link to the publication: www.tandfonline.com/doi/full/10.... #HEV #HepatitisE #Virology

Viral entry defines the hepatitis E virus species barrier in murine hepatocytes

The Paslahepevirus balayani hepatitis E virus (HEV) and the distantly related Rocahepevirus ratti rat HEV pose a risk for zoonotic transmission to humans. Despite the broad host range, including it...

tandfonline.com

Two new Masters in town! 🎓 Kudos to Celine and Pauline on earning their Master's degrees. Excited to welcome them back (soon) for their PhD theses @mmv-rub.bsky.social and @compvirol.bsky.social‬

1/5 Excited to share our latest work on hepatitis E virus evolution during acute infection published in mBio. journals.asm.org/doi/10.1128/...

Intra-host viral population dynamics during acute hepatitis E virus infection | mBio

The hepatitis E virus is the leading cause of acute viral hepatitis globally. While studies of chronic infections have shown that HEV can evolve and adapt in ways that influence antiviral treatment re...

journals.asm.org

🔥New paper out in _mBio_! By studying #hepatitisE #virus populations from acute infections, we uncover the earliest signatures of viral #evolution. Thanks to everyone who contributed! @ruhr-uni-bochum.de @hepe-hub-bochum.bsky.social @mmv-rub.bsky.social. 👇 journals.asm.org/eprint/GG7H8...

Intra-host viral population dynamics during acute hepatitis E virus infection | mBio

The hepatitis E virus is the leading cause of acute viral hepatitis globally. While studies of chronic infections have shown that HEV can evolve and adapt in ways that influence antiviral treatment responses, little is known about how the virus changes during the early, acute phase of infection. By analyzing viral populations in asymptomatic blood donors, this study demonstrates that HEV undergoes dynamic evolutionary changes even during short, self-limiting infections. Although overall viral diversity remains restricted, selective pressures still drive the emergence of new variants, including some with impaired replication capacity. These findings provide important mechanistic insight into early intra-host viral evolution and the conditions that allow defective variants to transiently persist. This work establishes a foundation for future studies linking viral genetic variation to disease progression, clinical outcomes, and treatment responsiveness.

journals.asm.org

Congrats to Maria Darido on receiving the German Liver Foundation's Networking Fellowship! 🎉 Her research on the early mechanisms HEV entry into host cells will be further advanced through a research stay at the University of Oldenburg. bit.ly/4vJElyD @hepe-hub-bochum.bsky.social

Vernetzungsstipendium für Maria Laura Goussain Darido

Die Forscherin aus der Virologie der Ruhr-Universität Bochum plant einen Aufenthalt in Oldenburg.

bit.ly

Exciting work presented by our master student Alina at EASL in Barcelona 🇪🇸 She presented her poster, “Replication assessment of chimeric HEV-3 subtypes demonstrates enhanced replication fitness of HEV-3f isolates” #EASL2026 #HEV #Virology #HepatitisE #LiverResearch

MMV @EASL in #Barcelona @easlnews.bsky.social

Bochumer Forschende suchen neue Behandlungsstrategien gegen #Hepatitis E. Aussichtsreich haben sie ein RNA-gerichtetes CRISPR-System getestet.

CRISPR-System hemmt Hepatitis-E-Virus

Eine enzymatische Schere erkennt und schneidet Virus-RNA, lässt aber die Wirtszelle in Ruhe. Das eröffnet neue antivirale Strategien gegen Hepatitis E.

news.rub.de

New manuscript @JHepReports – We used Cas13 to target #HepatitisE virus RNA 🧬✂️. Kudos to all autors👍 Paper: bit.ly/3Py2KaD @hepe-hub-bochum.bsky.social @compvirol.bsky.social

Development of a CRISPR-Cas13-based antiviral strategy against hepatitis E virus

Effective antiviral drugs remain unavailable for many clinically relevant pathogens, including the hepatitis E virus (HEV). This study aimed to evalua…

bit.ly

Das Andes-Virus ist weniger stabil als andere behüllte Viren. Desinfektionsmittel können es zuverlässig inaktivieren und eine Ansteckung verhindern.

Andes-Virus: Desinfektionsmittel wirken zuverlässig

Auf einem Kreuzfahrtschiff haben sich mehrere Personen mit dem Virus angesteckt. Handelsübliche Desinfektionsmittel inaktivieren es zuverlässig.

news.rub.de

✨Ever met a real Nobel laureate? We did. Great moment for the teams of @mmv-rub.bsky.social and @compvirol.bsky.social at the German Society for Virology Annual Meeting in Heidelberg with Charles Rice🏅. Science🧬, inspiration, and a snapshot to remember📸. @ruhr-uni-bochum.de

Last week, Prof. Eike Steinmann gave a talk "Hepatitis E Virus - - Recent Advances in Drug Development" as an invited speaker at the ICAR2026 in Prague. #HEV #HepatitisE #Research #Virology #RUB #HepEHub #ICAR2026

news.rub.de/presseinform...

Andes-Virus: Desinfektionsmittel wirken zuverlässig

Auf einem Kreuzfahrtschiff haben sich mehrere Personen mit dem Virus angesteckt. Handelsübliche Desinfektionsmittel inaktivieren es zuverlässig.

news.rub.de

Der Wirkstoff Apilimod könnte eine neue Hoffnung auf Behandlung von Hepatitis-E-Infektionen sein.

Neuer zellulärer Angriffspunkt verhindert Hepatitis-E-Infektion

Statt das Virus direkt anzugreifen, setzt die Verbindung bei der Wirtszelle an und verhindert die Infektion.

news.rub.de

Sehr intressantes Interview unsere GfV-Präsidentin. (BS) www.pharmazeutische-zeitung.de/am-ende-zaeh...

Virologin Ciesek beim PZ-Livetalk: »Am Ende zählt nicht, wer impft«

Die Frankfurter Virologin Sandra Ciesek plädiert für Apotheken als niedrigschwellige Zugangsorte für das Impfen. Im Prinzip zähle dabei...

pharmazeutische-zeitung.de

Cool perspective on our latest paper using bemnifosbuvir against #HEV in GUT @bmj.com. gut.bmj.com/content/earl... #HepatitisE #Research #Virology #RUB #HepEHub

Virologie Bochum@mmv-rub.bsky.social · 4mo ago

🚨 Bemnifosbuvir shows promise against hepatitis E virus 🚨 New study: Nucleotide analogue bemnifosbuvir inhibits HEV replication in preclinical models. 💻: gut.bmj.com/content/earl... #HEV #HepatitisE #Research #Virology #RUB #HepEHub

ℹ️ Apilimod blocks hepatitis E virus infection ℹ️ New study: PIKfyve inhibitor apilimod effectively blocks HEV infection. 🛋️ Read more: egastroenterology.bmj.com/content/4/1/... #HEV #HepatitisE #Research #Virology #RUB #HepEHub

Congratulations Tina 🎉 Thrilled to announce that Tina Sliwinski from @mmv-rub.bsky.social won the prestigous GBM Master Prize for her outstanding master's thesis 🔬 We're so proud of your achievement and look forward to your upcoming #PhD work on the spread of #HEV 🥼 @ruhr-uni-bochum.de

🔬 New insights into hepatitis E virus replication 🔬 Study reveals HEV replication occurs in proliferative cells within the intestinal crypt. Read more: www.science.org/doi/10.1126/... #HEV #HepatitisE #Research #Virology #RUB #HepEHub

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt

Hepatitis E virus infection of the self-renewing intestinal crypt reveals a previously unknownmechanism of viral persistence.

science.org

🚨 Bemnifosbuvir shows promise against hepatitis E virus 🚨 New study: Nucleotide analogue bemnifosbuvir inhibits HEV replication in preclinical models. 💻: gut.bmj.com/content/earl... #HEV #HepatitisE #Research #Virology #RUB #HepEHub

🚨 Hoffnung im Kampf gegen Hepatitis E: Als Teil eines internationalen Teams hat die @mmv-rub.bsky.social an der Identifizierung eines Wirkstoffs mitgewirkt, der die Virusvermehrung gezielt stoppt – mit großem Potenzial für neue Therapien. 🎙️Radio Interview: bit.ly/4cx2Ckl 📰 Read more: bit.ly/47NAyqg

Hoffnung gegen Hepatitis E: Wirkstoff hemmt die Vermehrung der Viren

deutschlandfunk.de

What a great meeting in Velbert last week 🔬 Under the title Advances in #HepatitisE Virus Infection Research, over 50 participants shared ideas and insights on clinical aspects, antiviral strategies, viral entry and replication 🧪 This is an amazing community, thanks to all of you 👇 #teamscience

Thanks to the Power of Didactics project at the University of Łódź, a member of the #UNIC, I had the opportunity to complete a short study visit at #MMV and #TRACIR at #RUB (Ruhr University Bochum). It was three days of learning and experiencing new scientific perspectives.

Welcome to the HepE-Hub Bochum! We're thrilled to connect the #virology & #infection research @mmv-rub.bsky.social & @compvirol.bsky.social here at @ruhr-uni-bochum.de with its 5 uni clinics to boost #HepatitisE research & patient care. Join us in our mission! #teamscience hepe-hub-bochum.de/en/

Exciting news! 🎉 We’re proud to be part of the new HepE-Hub Bochum initiative! Together with the uni clinics of @ruhr-uni-bochum.de and @mmv-rub.bsky.social, we’re committed to improve #HepatitisE virus #research and #healthcare Check it out 🔎 #virology #infectionresearch #TRACiR

HepE-Hub Bochum@hepe-hub-bochum.bsky.social · 7mo ago

Welcome to the HepE-Hub Bochum! We're thrilled to connect the #virology & #infection research @mmv-rub.bsky.social & @compvirol.bsky.social here at @ruhr-uni-bochum.de with its 5 uni clinics to boost #HepatitisE research & patient care. Join us in our mission! #teamscience hepe-hub-bochum.de/en/

@andregoemer.bsky.social diving into emerging Hepeviruses at the Applied Hygiene, Microbiology & Virology Conference.

Congrats @MaraKloehn great talk and a price 😁 at the FoRUM Tagung 2025 @ruhr-uni-bochum.de.

Ein Forschungsteam hat einen bislang unbekannten zellulären Mechanismus identifiziert, der für die Vermehrung von Coronaviren entscheidend ist.

Neu entdeckter Wirt-Mechanismus bei Coronaviren

Die Entdeckung könnte ein Ausgangspunkt für antivirale Strategien sein.

news.rub.de

Kudos @naturfuchs.bsky.social – cool talk #HCVFlavi2025 on rat liver cells as a model to study reverse zoonosis.

Our editorial “Rat Hepatitis E Virus: An Emerging Challenge in Human Hepatitis” is now out in the Journal of Hepatology! 👏 Thanks to Katja Dinkelborg (Medical School Hannover) and Sébastien Lhomme (CHU Toulouse) for the great teamwork and congrats to Lo et al. for their excellent original study!