www.cell.com/cell-genomic... This was a great collaboration and great work by Ilse Krätschmer. We show there is greater potential for indirect genetic effects than previously thought and a small role of parent-of-origin effects in shaping quantitative trait variation.

Separating direct, indirect, and parent-of-origin genetic effects in the human population

Krätschmer et al. develop a novel statistical approach to distinguish between direct genetic effects (DGE), indirect genetic effects (IGE) (how parental DNA shapes the child’s environment), and parent...

cell.com

We are looking forward to trying this out. The memory footprint of joint analyses, which require holding all genotypes data in RAM has always been a limiting factor for us.

April Wei@aprilwei.bsky.social · 4mo ago

Very proud to share our new work on General, orders-of-magnitude faster whole-genome analysis with genotype representation graphs (GRG). We topped ourselves in this one 🚀 and made GRG a practical foundation for biobank-scale population and statistical genetics. www.biorxiv.org/content/10.6...

An approach to jointly model associations with time-to-event outcomes that reduces false positives.

bioRxivpreprint@biorxivpreprint.bsky.social · 3mo ago

Joint Variable Selection for Omic Biomarkers in Time-to-Event Data https://www.biorxiv.org/content/10.64898/2026.04.30.721585v1

Just sharing our most recent preprint. Would welcome feedback. Sex differences in the genetic basis of human recombination within 190,000 parent-child pairs. www.biorxiv.org/content/10.6...