We've got a new preprint posted, you can read all about it (and see a picture of our recently adopted lab mascot) here: eltinglab.github.io/news/taylorB... The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.

Wonderfully clear thread about some of the things ‘indirect costs’ support

Of all the takes on this story, this is clearly the right one

𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡@arnaudjlegrand.bsky.social · 2y ago

Brain surgery... it’s not exactly rocket science, is it?”

Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...

Brings to mind this quote from Stephen J Gould: "I am, somehow, less interested in the weight and convolutions of Einstein's brain than in the near certainty that people of equal talent have lived and died in cotton fields and sweatshops."

Alejandro Montenegro@aemonten.bsky.social · 2y ago

"Unlike most of my scientific colleagues, I was not academically brilliant. I never won scholarships and would probably not have been able to attend Cambridge University if my parents had not been fairly rich" - Frederick Sanger

Happy #microscopymonday! Here is a collaborative project I started in ~2018, looking at different cells stained for actin and DNA and all set to the same scale. More info (and poster printouts!) here: katrinavelle.wixsite.com/science/prin...

Q: What's wrong with these plots? A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility. Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...

Every time I see this movie it looks like embroidery to me. And now that might be a thing I have to figure out how to make. But maybe someone has already done this? Other scientists who stitch on here?

Neil Ranson@naranson.bsky.social · 2y ago

Hey Bluesky! For my first post thought I'd share this awesome movie made by Phopho Biomedical Animation for our recent paper on the folding of bacterial outer membrane proteins in Nature Comms: doi.org/10.1038/s414... #cryoEM #AstburyCentre

I swear I didn’t put J up to this. But y’all. What if I’m raising a chemist?! 🙈 #physicistMom

Probably my favorite movie I’ve seen this year, thanks Needhi for verbalizing what I found so moving about it

Needhi Bhalla 💅🏽@needhibhalla.bsky.social · 2y ago

Watching the movie “Will and Harper” and deeply appreciate this framing as Harper re-negotiating her relationship with the country, which I think is a reality so many of us have had to do at some point in our lives

I did my first protein prep (myosin VI!) using tap water. Yeah, I was ‘that physicist.’

Tiffany Lowe-Power stands with Minnesota@tlowepower.bsky.social · 2y ago

🧪🧫 Scientist friends, as we are building community here, I have a question to get to know you: What is a mistake that you made in the lab?

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN

🧪 Punchline of our most recent preprint about how a giant single cell changes shape super fast, check the thread for more info!

Mary Williard Elting@mwelting.bsky.social · 2y ago

Overall, we hypothesize a multi-scale model that can explain Spirostomum contraction from the molecular (nanometer) to the organismal (millimeter) scale. Not only is this mechanism unusual (and plain cool!), it gives us a new blueprint to control or even synthetically actuate contractility. 12/13

Wow this is good. Will be sharing widely.

Anna Rogers@annarogers.bsky.social · 2y ago

Shameless plug: a post on 'writing as thinking' that I wrote for my own students hackingsemantics.xyz/2024/writing/

Very excited to share a thread about our new preprint! It's a highly collaborative project, w key contributions from @josephlannan.bsky.social (in my lab) @bhamlalab.bsky.social (+ GS Luke Xu), Dinner Lab (+ PD Cal Floyd), Jerry Honts, Marshall lab (+ GS Connie Yan), and Suri Vaikuntanathan 1/13

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Fishnet mesh of centrin-Sfi1 drives ultrafast calcium-activated contraction of the giant cell Spirostomum ambiguum https://www.biorxiv.org/content/10.1101/2024.11.07.622534v1

Fishnet mesh of centrin-Sfi1 drives ultrafast calcium-activated contraction of the giant cell Spirostomum ambiguum https://www.biorxiv.org/content/10.1101/2024.11.07.622534v1

Fishnet mesh of centrin-Sfi1 drives ultrafast calcium-activated contraction of the giant cell Spirostomum ambiguum https://www.biorxiv.org/content/10.1101/2024.11.07.622534v1

Spirostomum is a unicellular ciliate capable of contracting to a quarter of its body length in less

biorxiv.org

Alrighty, events of the last week or so have pushed me over the edge to finally figure out how this thing works.